Q.

Reports of cardiac arrhythmias caused by unusually high blood levels of 2 antihistamines (terfenadine and astemizole) are best explained by

A. Concomitant treatment with phenobarbital
B. Use of these drugs by smokers
C. Use of antihistamines by persons of Asian background
D. A genetic predisposition to metabolise succinylcholine slowly
E. Treatment of these patients with ketoconazole
Answer» E. Treatment of these patients with ketoconazole
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