Q.

Which of the following is true for monolithic devices?

A. these devices are used when the drug permeation rate is rapid
B. the release of the drug is controlled
C. suitable for drugs with large therapeutic indices
D. the drug is contained in a powder form floating on liquid
Answer» C. suitable for drugs with large therapeutic indices
Explanation: the drug used in these devices has a large therapeutic index. the drug release rate from the matrix is rapid initially and then falls as the matrix gets depleted of the drug. the polymer employed for the matrix system may be hydrophilic or lipophilic. these polymers include pvc, pvp, and polysaccharides.
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