McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Biology .
Chapters
| 1. |
Which of the following drugs has an average half life of 50 hours? |
| A. | Nortriptylline |
| B. | Digoxin |
| C. | Trimethoprim |
| D. | Valproic acid |
| E. | Lithium |
| Answer» B. Digoxin | |
| 2. |
All of the following have 100% oral bioavailability EXCEPT |
| A. | Valproic acid |
| B. | Trimethoprim |
| C. | Digoxin |
| D. | Diazepam |
| E. | Lithium |
| Answer» C. Digoxin | |
| 3. |
All of the following drugs are >90% plasma protein bound EXCEPT |
| A. | Diazepam |
| B. | Frusemide |
| C. | Fluoxetine |
| D. | Gentamicin |
| E. | Warfarin |
| Answer» D. Gentamicin | |
| 4. |
Which of the following drugs has a volume of distribution >2000 ℓ/70kg? |
| A. | Aspirin |
| B. | Imipramine |
| C. | Digoxin |
| D. | Propranolol |
| E. | Chloroquine |
| Answer» E. Chloroquine | |
| 5. |
What is the half life of a drug with a volume of distribution of 100ℓ/70kg and a clearance of 7ℓ/hr/70kg |
| A. | 5 hours |
| B. | 10 hours |
| C. | 12.5 hours |
| D. | 15 hours |
| E. | 20 hours |
| Answer» B. 10 hours | |
| 6. |
All of the following drugs exhibit flow dependent elimination EXCEPT |
| A. | Atenolol |
| B. | Isoniazid |
| C. | Propoxyphene |
| D. | Amitriptylline |
| E. | Lignocaine |
| Answer» A. Atenolol | |
| 7. |
Which of the following undergoes a phase I hydrolysis reaction? (biotransformation) |
| A. | Ethanol |
| B. | Naloxone |
| C. | Morphine |
| D. | Lignocaine |
| E. | Diazepam |
| Answer» D. Lignocaine | |
| 8. |
Which of the following undergoes acetylation in the liver? (Phase 2 biotransformation) |
| A. | Isoniazid |
| B. | Acetaminophen |
| C. | Salicylic acid |
| D. | Epinephrine |
| E. | Diazepam |
| Answer» A. Isoniazid | |
| 9. |
A D Response B C Concentration Which of these drugs is the most efficacious? |
| A. | Drugs A and B |
| B. | Drug C |
| C. | Drugs A and D |
| D. | Drugs D and C |
| E. | Drug A |
| Answer» C. Drugs A and D | |
| 10. |
Referring to the graph in question 9 – which of the drugs is most potent? |
| A. | A |
| B. | B |
| C. | C |
| D. | D |
| E. | A and B |
| Answer» A. A | |
| 11. |
EC50 is |
| A. | Measured with a radioactive receptor |
| B. | Always equal to Kd |
| C. | Drug concentration with 50% receptors bound |
| D. | Representation of the receptors affinity for drug binding |
| E. | Drug concentration with 50% of maximal drug effect |
| Answer» E. Drug concentration with 50% of maximal drug effect | |
| 12. |
Which of the following will NOT alter the volume of distribution of a drug? |
| A. | Cardiac failure |
| B. | Clearance |
| C. | Age |
| D. | Burns |
| E. | Pleural effusion |
| Answer» B. Clearance | |
| 13. |
Volume of distribution equals |
| A. | Dose given/plasma concentration |
| B. | Total amount of drug in the body/plasma concentration |
| C. | Urine drug concentration/plasma concentration |
| D. | Dose given/urine concentration |
| E. | Urine drug concentration/plasma concentration |
| Answer» B. Total amount of drug in the body/plasma concentration | |
| 14. |
Which of the following drugs undergoes rate limited elimination? |
| A. | Lignocaine |
| B. | Morphine |
| C. | Warfarin |
| D. | Propanolol |
| E. | Aspirin |
| Answer» E. Aspirin | |
| 15. |
Ligand gated channel receptors include all of the following EXCEPT |
| A. | GABA |
| B. | Aspartate |
| C. | Glycine |
| D. | Glutamate |
| E. | Ach-muscarinic |
| Answer» E. Ach-muscarinic | |
| 16. |
Regarding receptor regulation |
| A. | Receptor down regulation occurs over hours – days |
| B. | Receptor responses to drugs often “desensitise” with time – this desensitisation is usually irreversible |
| C. | The mechanism of agonist induced desensitisation of the nicotinic Ach receptor has been worked out in detail |
| D. | All “internalised” receptors are degraded by lysosomes |
| E. | None of the above are correct |
| Answer» A. Receptor down regulation occurs over hours – days | |
| 17. |
Which of the following acts on intracellular receptors |
| A. | Serotonin |
| B. | Glucagon |
| C. | Corticosteroids |
| D. | GABA |
| E. | Insulin |
| Answer» C. Corticosteroids | |
| 18. |
Which of the following has ↑ bioavailability in the neonate when compared with older children/adults? |
| A. | Penicillin |
| B. | Digoxin |
| C. | Acetaminophen |
| D. | Diazepam |
| E. | Phenobarbital |
| Answer» A. Penicillin | |
| 19. |
First order kinetics |
| A. | Means rate of reaction is proportional to concentration |
| B. | Are more common than zero order kinetics |
| C. | Apply to exponential processes |
| D. | Generally apply to high plasma concentrations (>20mg/100ml) of ethanol |
| E. | Result in steady state concentrations after multiple dosing |
| Answer» D. Generally apply to high plasma concentrations (>20mg/100ml) of ethanol | |
| 20. |
A single compartment model means that |
| A. | One exponential term describes the decreasing plasma concentration of the drug |
| B. | A single exponential term describes the rise in plasma concentration following oral administration |
| C. | The drug does not penetrate tissues |
| D. | The drug is restricted to the ECF |
| E. | The drug is highly ionised |
| Answer» A. One exponential term describes the decreasing plasma concentration of the drug | |
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