The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.

Related MCQs

• What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearance of creatinine is 95ml/min?
• What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?
• Displacement is significant when, the displaced drug is more than protein bound.
• For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?
• Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.
• To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?
• Penicillin has short plasma half-life although it can bind to plasma protein rigidly.
• The extent of drug-protein binding can change with both changes in protein and drug concentration.
• Two most common protein involved in plasma protein binding are
• For a drug that is eliminated primarily by renal glomerular filtration, the theoretical maximum clearance is approximately