McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
| 1. |
In cardiac glycoside, position of β- unsaturated lactone ring is |
| A. | C – 3 |
| B. | C – 14 |
| C. | C – 17 |
| D. | C – 23 |
| Answer» C. C – 17 | |
| 2. |
Activity of cardiac glycoside depends to a great extent on |
| A. | 23rd carbonyl oxygen |
| B. | C – 3 OH |
| C. | Side chain at C – 14 |
| D. | Side chain at C – 17 |
| Answer» A. 23rd carbonyl oxygen | |
| 3. |
Angiotensin II causes rise in blood pressure by: |
| A. | Direct vasoconstriction |
| B. | Releasing adrenaline from adrenal medulla |
| C. | Increasing central sympathetic tone |
| D. | All of the above |
| Answer» D. All of the above | |
| 4. |
Digitalis slows the heart in congestive heart failure by: |
| A. | Increasing vagal tone |
| B. | Decreasing sympathetic overactivity |
| C. | Direct depression of sinoatrial node |
| D. | All of the above |
| Answer» D. All of the above | |
| 5. |
Methyldopa is |
| A. | Parasympathomimetic |
| B. | Parasympatholytic |
| C. | Sympathomimetic |
| D. | Sympatholytic |
| Answer» D. Sympatholytic | |
| 6. |
Losartan is |
| A. | Renin release blocker |
| B. | ACE inhibitor |
| C. | Angiotension I blocker |
| D. | Angiotension II blocker |
| Answer» C. Angiotension I blocker | |
| 7. |
IUPAC name of Dobutamine is |
| A. | 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol |
| B. | 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}methyl)benzene-1,2-diol |
| C. | 4-(2-{[4-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)benzene-1,2-diol |
| D. | 4-(2-{[4-(4-hydroxyphenyl) propan -2-yl]amino}methyl)benzene-1,2-diol |
| Answer» A. 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol | |
| 8. |
1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol is IUPAC name of |
| A. | Atenolol |
| B. | Metoprolol |
| C. | Captopril |
| D. | Hydralazine |
| Answer» B. Metoprolol | |
| 9. |
Hydralazine is synthesized from |
| A. | 2-formyl benzoic acid and Hydrazine |
| B. | Methacrylic acid |
| C. | 2-azidoethanol |
| D. | o-nitro toluene |
| Answer» A. 2-formyl benzoic acid and Hydrazine | |
| 10. |
The principal action common to all class I antiarrhythmic drugs is: |
| A. | Na+ channel blockade |
| B. | K+ channel opening |
| C. | Depression of impulse conduction |
| D. | Prolongation of effective refractory period |
| Answer» A. Na+ channel blockade | |
| 11. |
Identify high ceiling diuretic. |
| A. | Chlorthiazide |
| B. | Furosemide |
| C. | Spironolactone |
| D. | Amiloride |
| Answer» B. Furosemide | |
| 12. |
_____________ is carboxylic acid moiety containing. |
| A. | Captopril |
| B. | Enalapril |
| C. | Fosinopril |
| D. | Bepridil |
| Answer» B. Enalapril | |
| 13. |
Given structure is of |
| A. | Captopril |
| B. | Enalapril |
| C. | Fosinopril |
| D. | Bepridil |
| Answer» B. Enalapril | |
| 14. |
_____________ is sulfhydryl moiety containing. |
| A. | Captopril |
| B. | Enalapril |
| C. | Fosinopril |
| D. | Bepridil |
| Answer» A. Captopril | |
| 15. |
Given drug is |
| A. | α blocker |
| B. | β blocker |
| C. | K+ channel blocker |
| D. | Ca++ channel blocker |
| Answer» D. Ca++ channel blocker | |
| 16. |
The antiarrhythmic drug which decreases both rate of depolarization (phase 0) as well as rate of repolarization (phase 3) of myocardial fibres is: |
| A. | Lignocaine |
| B. | Propranolol |
| C. | Quinidine |
| D. | Verapamil |
| Answer» C. Quinidine | |
| 17. |
The following drug is used to reduce the frequency of angina pectoris as well as to terminate an acute attack: |
| A. | Isosorbide dinitrate |
| B. | Pentaerythritol tetranitrate |
| C. | Diltiazem |
| D. | Dipyridamole |
| Answer» A. Isosorbide dinitrate | |
| 18. |
Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate: |
| A. | Coronary |
| B. | Cutaneous |
| C. | Renal |
| D. | Cranial |
| Answer» C. Renal | |
| 19. |
Phase II in cardiac action potential is |
| A. | Fast depolarization |
| B. | Partial repolarization |
| C. | Plateau |
| D. | Repolarization |
| Answer» C. Plateau | |
| 20. |
In HMG-CoA-Reductase Inhibitors, Lactone ring may be substituted at |
| A. | C- 15 |
| B. | C- 16 |
| C. | C-17 |
| D. | C -18 |
| Answer» C. C-17 | |
| 21. |
2-(diethylamino)-N-(2,6-dimethylphenyl) Acetamide is IUPAC name of |
| A. | Flecainide |
| B. | Atenolol |
| C. | Verapamil |
| D. | Lignocaine |
| Answer» D. Lignocaine | |
| 22. |
Select the organic nitrate which undergoes minimal first-pass metabolism in the liver: |
| A. | Glyceryl trinitrate |
| B. | Isosorbide dinitrate |
| C. | Isosorbide mononitrate |
| D. | Erythrityl tetranitrate |
| Answer» C. Isosorbide mononitrate | |
| 23. |
The primary mechanism of beneficial effect of glyceryl trinitrate in classical angina pectoris is: |
| A. | Increase in total coronary blood flow |
| B. | Redistribution of coronary blood flow |
| C. | Reduction of cardiac preload |
| D. | Reduction of cardiac afterload |
| Answer» C. Reduction of cardiac preload | |
| 24. |
Organic nitrates relax vascular smooth muscle by: |
| A. | Increasing intracellular cyclic GMP |
| B. | Increasing intracellular cyclic AMP |
| C. | Decreasing intracellular cyclic AMP |
| D. | Both ‘A’ and ‘C’ are correct |
| Answer» A. Increasing intracellular cyclic GMP | |
| 25. |
Nitrate tolerance is least likely to develop with the use of: |
| A. | Sustained release oral glyceryl trinitrate |
| B. | Sublingual glyceryl trinitrate |
| C. | Transdermal glyceryl trinitrate |
| D. | Oral pentaerythritol tetranitrate |
| Answer» B. Sublingual glyceryl trinitrate | |
| 26. |
Glyceryl trinitrate is administered by the following routes except: |
| A. | Oral |
| B. | Sublingual |
| C. | Intramuscular |
| D. | Intravenous |
| Answer» C. Intramuscular | |
| 27. |
Myocardial Na+ channel blockade by lignocaine has the following characteristic: |
| A. | It blocks inactivated Na+ channels more than activated channels |
| B. | It blocks activated Na+ channels more than inactivated channels |
| C. | It delays rate of recovery of Na+ channels |
| D. | It produces more prominent blockade of atrial than ventricular Na+ channels |
| Answer» A. It blocks inactivated Na+ channels more than activated channels | |
| 28. |
Hypothyroidism is a possible consequence of prolonged therapy with: |
| A. | Amiodarone |
| B. | Mexiletine |
| C. | Sotalol |
| D. | Procainamide |
| Answer» A. Amiodarone | |
| 29. |
The following is true of procainamide except: |
| A. | It generates an active metabolite in the body |
| B. | Its plasma half-life is longer than that of quinidine |
| C. | On long-term use, it can cause systemic lupus erythematosus like illness |
| D. | It is effective in many cases of ventricular extrasystoles, not responding to lignocaine |
| Answer» B. Its plasma half-life is longer than that of quinidine | |
| 30. |
The most significant feature of the antiarrhythmic action of is: |
| A. | Suppression of phase-4 depolarization in ventricular ectopic foci |
| B. | Prolongation of action potential duration |
| C. | Prolongation of effective refractory period |
| D. | Depression of membrane responsiveness |
| Answer» A. Suppression of phase-4 depolarization in ventricular ectopic foci | |
| 31. |
Quinidine is now used primarily for: |
| A. | Conversion of atrial fibrillation to sinus rhythm |
| B. | Control of ventricular rate in atrial flutter |
| C. | Termination of ventricular tachycardia |
| D. | Prevention of recurrences of atrial fibrillation/ ventricular tachycardia |
| Answer» D. Prevention of recurrences of atrial fibrillation/ ventricular tachycardia | |
| 32. |
The following antiarrhythmic drug has the most prominent anticholinergic action: |
| A. | Disopyramide |
| B. | Quinidine |
| C. | Procainamide |
| D. | Lignocaine |
| Answer» A. Disopyramide | |
| 33. |
The following is not true about : |
| A. | It blocks myocardial Na+ channels primarily in the open state |
| B. | It has no effect on myocardial K+ channels |
| C. | It produces frequency dependent blockade of myocardial Na+ channels |
| D. | It delays recovery of myocardial Na+ channels |
| Answer» B. It has no effect on myocardial K+ channels | |
| 34. |
Beneficial effect/effects of diuretics in CHF patients include the following: |
| A. | Symptomatic relief |
| B. | Regression of pathological changes |
| C. | Prolongation of life expectancy |
| D. | Both ‘A’ and ‘C’ |
| Answer» A. Symptomatic relief | |
| 35. |
Glyceryl trinitrate is used in CHF for: |
| A. | Routine treatment of mild to moderate chronic heart failure |
| B. | Rapid symptom relief in acute left ventricular failure |
| C. | Arresting disease progression |
| D. | Both 'A' and 'B' |
| Answer» B. Rapid symptom relief in acute left ventricular failure | |
| 36. |
Vasodilators are used to treat: |
| A. | Acute heart failure attending myocardial infarction |
| B. | Chronic heart failure due to diastolic dysfunction |
| C. | Chronic heart failure due to both systolic as well as diastolic dysfunction |
| D. | All of the above |
| Answer» D. All of the above | |
| 37. |
Given drug is administered by the following routes except: |
| A. | Oral |
| B. | Sublingual |
| C. | Intramuscular |
| D. | Intravenous |
| Answer» C. Intramuscular | |
| 38. |
Which of the following drugs is most likely to accentuate varient (Prinzmetal) angina? |
| A. | Propranolol |
| B. | Atenolol |
| C. | Verapamil |
| D. | Dipyridamole |
| Answer» A. Propranolol | |
| 39. |
The following antianginal drug is most likely to produce tachycardia as a side effect: |
| A. | Amlodipine |
| B. | Nifedipine |
| C. | Diltiazem |
| D. | Verapamil |
| Answer» B. Nifedipine | |
| 40. |
The cardiac response to verapamil and nifedipine in human subjects is: |
| A. | Verapamil causes tachycardia while nifedipine causes bradycardia |
| B. | Both cause bradycardia |
| C. | Verapamil causes bradycardia while nifedipine causes tachycardia |
| D. | Both cause tachycardia |
| Answer» C. Verapamil causes bradycardia while nifedipine causes tachycardia | |
| 41. |
Propranolol should not be prescribed for a patient of angina pectoris who is already receiving: |
| A. | Nifedipine |
| B. | Felodipine |
| C. | Verapamil |
| D. | Isosorbide mononitrate |
| Answer» C. Verapamil | |
| 42. |
Given drug is |
| A. | Nifedipine |
| B. | Felodipine |
| C. | Verapamil |
| D. | Isosorbide mononitrate |
| Answer» C. Verapamil | |
| 43. |
The short acting dihydropyridine preparations can aggravate myocardial ischaemia by invoking: |
| A. | Coronary vasospasm |
| B. | Thrombus formation |
| C. | Vagal activation |
| D. | Reflex sympathetic discharge to the heart |
| Answer» D. Reflex sympathetic discharge to the heart | |
| 44. |
Which of the following drugs is a potassium channel opener? |
| A. | Nicorandil |
| B. | Hydralazine |
| C. | Glibenclamide |
| D. | Amiloride |
| Answer» A. Nicorandil | |
| 45. |
The characteristic feature(s) of dihydropyridine calcium channel blockers is/are: |
| A. | They have minimal negative inotropic action on the heart |
| B. | They have no effect on A-V conduction |
| C. | They do not affect the activation-inactivation kinetics of the calcium channels |
| D. | All of the above |
| Answer» D. All of the above | |
| 46. |
The dihydropyridines block the following type of calcium channels: |
| A. | L-type voltage sensitive channels |
| B. | T-type voltage sensitive channels |
| C. | N-type voltage sensitive channels |
| D. | Receptor operated calcium channels |
| Answer» A. L-type voltage sensitive channels | |
| 47. |
Select the drug which is a potassium channel opener as well as nitric oxide donor: |
| A. | Diazoxide |
| B. | Sodium nitroprusside |
| C. | Minoxidil |
| D. | Nicorandil |
| Answer» D. Nicorandil | |
| 48. |
Though nitrates and calcium channel blockers are both vasodilators, they are used concurrently in angina pectoris, because: |
| A. | They antagonise each other’s side effects |
| B. | Nitrates primarily reduce preload while calcium channel blockers primarily reduce after-load |
| C. | Nitrates increase coronary flow while calcium channel blockers reduce cardiac work |
| D. | Both ‘B’ and ‘C’ are correct |
| Answer» B. Nitrates primarily reduce preload while calcium channel blockers primarily reduce after-load | |
| 49. |
The most likely mechanism of antihypertensive action of thiazide diuretics in the long-term is: |
| A. | Reduction of circulating blood volume |
| B. | Reduction in cardiac output |
| C. | Decreased sympathetic tone |
| D. | Reduction in total peripheral vascular resistance and improved compliance of resistance Vessels |
| Answer» D. Reduction in total peripheral vascular resistance and improved compliance of resistance Vessels | |
| 50. |
Rapid intravenous injection of clonidine causes rise in BP due to: |
| A. | Stimulation of vasomotor centre |
| B. | Release of noradrenaline from adrenergic nerve endings |
| C. | Agonistic action on vascular α adrenergic receptors |
| D. | Cardiac stimulation |
| Answer» C. Agonistic action on vascular α adrenergic receptors | |
Done Studing? Take A Test.
Great job completing your study session! Now it's time to put your knowledge to the test. Challenge yourself, see how much you've learned, and identify areas for improvement. Don’t worry, this is all part of the journey to mastery. Ready for the next step? Take a quiz to solidify what you've just studied.