McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 1. |
The concentration of drug in plasma above which toxic effects are precipitated is known as |
| A. | Maximum safe concentration |
| B. | Minimum Effective Concentration |
| C. | Intensity of Action |
| D. | Duration of Action |
| Answer» A. Maximum safe concentration | |
| 2. |
When rate is independent of the reactant concentration, then it is called |
| A. | zero order reaction |
| B. | Pseudo zero order reaction |
| C. | First order reaction |
| D. | Second order reaction |
| Answer» A. zero order reaction | |
| 3. |
Which of the following is the half life of zero order reaction? |
| A. | t1/2 = A0 /2k |
| B. | t1/2 = 0.693/2k |
| C. | t1/2 = A0 /2 |
| D. | t1/2 = 2k/ A0 |
| Answer» A. t1/2 = A0 /2k | |
| 4. |
The unit of k for zero order reaction is |
| A. | moles/litre/second |
| B. | moles |
| C. | moles/second |
| D. | moles/litre |
| Answer» A. moles/litre/second | |
| 5. |
Which of the following is the half life of first order reaction? |
| A. | t1/2 = A0 / 2k |
| B. | t1/2 = 0.693 / 2k |
| C. | tl/2 = 2k |
| D. | tl/2 = 0.693 / k |
| Answer» D. tl/2 = 0.693 / k | |
| 6. |
Which of the following is not a pharmacokinetic parameters that describe the plasma level time curve? |
| A. | tmax |
| B. | cmax |
| C. | Area under Curve |
| D. | Minimum Effective Concentration |
| Answer» D. Minimum Effective Concentration | |
| 7. |
The drug concentration between Minimum Effective Concentration and Maximum Safe Concentration is called |
| A. | Therapeutic range |
| B. | Area under curve |
| C. | Peak response |
| D. | Pharmacological response |
| Answer» A. Therapeutic range | |
| 8. |
tmax indicates |
| A. | drug absorption rate |
| B. | drug elimination rate |
| C. | drug distribution rate |
| D. | drug metabolism rate |
| Answer» A. drug absorption rate | |
| 9. |
What Will be the approximate Tmax of a drug exhibiting Ka of 2 hr-1 and K of 0.2 hr-1 ? |
| A. | 1.2 hr |
| B. | 2.4 hr |
| C. | 4.8 hr |
| D. | 2.0 hr |
| Answer» A. 1.2 hr | |
| 10. |
A drug solution has half life of 21 days. Assuming that drug undergoes first order kinetics, how long will it take for the potency to drop to 90% of initial potency? |
| A. | 3.2 days |
| B. | 9.6 days |
| C. | 16 days |
| D. | 6.2 days |
| Answer» A. 3.2 days | |
| 11. |
A suspension shows zero-order kinetic with a rate constant 2mg/ml.month. The dose of suspension is 20mg/ml. The biological half life of the above dosage form is |
| A. | 5 months |
| B. | 1 month |
| C. | 3 months |
| D. | 2 months |
| Answer» A. 5 months | |
| 12. |
Drug showing zero order kinetic of elimination |
| A. | Are more common than those showing first order kinetic |
| B. | Show plot of drug concentration vs time (linear Plot) |
| C. | Decrease in concentration exponentially with time |
| D. | Have half life independent of dose |
| Answer» B. Show plot of drug concentration vs time (linear Plot) | |
| 13. |
Elimination after 4 half lives in first order kinetics is |
| A. | 84% |
| B. | 93% |
| C. | 80% |
| D. | 4% |
| Answer» B. 93% | |
| 14. |
Which one is irrational statement for first order kinetics? |
| A. | Half life is a function of concentration of reactants |
| B. | Reaction rate is not a function of concentration of reactants |
| C. | Both a & b |
| D. | All of these |
| Answer» D. All of these | |
| 15. |
T % (Half life time) of a drug can determine all of the following except |
| A. | Closing interval |
| B. | Therapeutic dose |
| C. | Elimination time |
| D. | Steady plasma concentration |
| Answer» B. Therapeutic dose | |
| 16. |
The area under serum concentration time curve of drug represents |
| A. | The biological half life of the drug |
| B. | Amount of drug biotransformed |
| C. | The amount of drug absorbed |
| D. | The amount of drug excreted in urine |
| Answer» D. The amount of drug excreted in urine | |
| 17. |
Under non compartment analysis the following formula is used for calculation |
| A. | MRT = AUMC / AUC |
| B. | AUMC = MRT / AUC |
| C. | MRT = AUC / AUMC |
| D. | AUC = AUMC / MRT |
| Answer» A. MRT = AUMC / AUC | |
| 18. |
Under compartment modeling, Wegner-Nelson-Method involves |
| A. | Determination of absorption rate constant (Ka) from %ARA Vs time curve |
| B. | Determination of elimination rate constant (Ka) from % ARA Vs time curve |
| C. | Determination of absorption rate constant (Ke) from %ARA •Vs Concentration curve |
| D. | Determination of plasma half life |
| Answer» A. Determination of absorption rate constant (Ka) from %ARA Vs time curve | |
| 19. |
The steady-state concentration of a drug can be double by: |
| A. | Doubling the both rate of infusion and concentration of drug. |
| B. | Doubling the rate of infusion only. |
| C. | Doubling the loading dose but maintaining the infusion rate. |
| D. | Tripling the rate of infusion. |
| Answer» B. Doubling the rate of infusion only. | |
| 20. |
In compartment modeling the term "Open" indicates |
| A. | Unidirectional input and output |
| B. | All compartments are open |
| C. | Body is open |
| D. | None of the above |
| Answer» A. Unidirectional input and output | |
| 21. |
Select the formula to calculate steady state concentration follows IV infusion |
| A. | Css= Infusion Rate/ Clearance |
| B. | Css= Clearance / Infusion Rate |
| C. | Css= Infusion Rate X Clearance |
| D. | Css = Infusion Rate - Clearance |
| Answer» A. Css= Infusion Rate/ Clearance | |
| 22. |
IV infusion model follows |
| A. | Zero order absorption and first order elimination kinetic |
| B. | No absorption and first order elimination kinetic |
| C. | No absorption and Zero order elimination kinetic |
| D. | First order absorption and first order elimination kinetic |
| Answer» A. Zero order absorption and first order elimination kinetic | |
| 23. |
Select the formula to calculate elimination half life |
| A. | t1/2 = 0.693 + Ke |
| B. | t1/2 = 0.693 / Ke |
| C. | t1/2 = 0.693 × Ke |
| D. | t1/2 = 0.693 – Ke |
| Answer» B. t1/2 = 0.693 / Ke | |
| 24. |
The constants that represent reversible transfer of drug between compartments are called as |
| A. | microconstants |
| B. | macroconstant |
| C. | Infusion |
| D. | Lag time |
| Answer» A. microconstants | |
| 25. |
In two compartment model, extravascular route of drug administration, there are ……phases |
| A. | absorption phase, |
| B. | Distribution phase |
| C. | elimination phase, |
| D. | All of the above |
| Answer» D. All of the above | |
| 26. |
Ka is estimated by |
| A. | Method of Residuals |
| B. | Loo Riegelman method |
| C. | Both a and b |
| D. | None of the above |
| Answer» C. Both a and b | |
| 27. |
The central compartment consist of |
| A. | Highly perfused tissues |
| B. | Slowly equilibrate tissues |
| C. | Both a and b |
| D. | Reproductive org |
| Answer» A. Highly perfused tissues | |
| 28. |
What does "pharmacokinetics" includes? |
| A. | Mechanisms of drug action |
| B. | Localization of drug action |
| C. | Interaction of substances |
| D. | Excretion of substances |
| Answer» D. Excretion of substances | |
| 29. |
Pharmacokinetics is: |
| A. | The study of absorption, distribution, metabolism and excretion of drugs |
| B. | The study of biological and therapeutic effects of drugs |
| C. | The study of methods of new drug development |
| D. | The study of mechanisms of drug action |
| Answer» A. The study of absorption, distribution, metabolism and excretion of drugs | |
| 30. |
What does "pharmacokinetics" includes? |
| A. | Drug biotransformation in the organism |
| B. | Influence of drugs on metabolism processes |
| C. | Influence of drugs on genes |
| D. | Complications of drug therapy |
| Answer» A. Drug biotransformation in the organism | |
| 31. |
Parenteral administration: |
| A. | Is too slow for emergency use |
| B. | Cannot be used with unconsciousness patients |
| C. | Generally results in a less accurate dosage than oral administration |
| D. | Usually produces a more rapid response than oral administration |
| Answer» D. Usually produces a more rapid response than oral administration | |
| 32. |
The volume of distribution (Vd) relates: |
| A. | The amount of a drug in the body to the concentration of a drug in plasma |
| B. | An uncharged drug reaching the systemic circulation |
| C. | Single to a daily dose of an administrated drug |
| D. | An administrated dose to a body weight |
| Answer» A. The amount of a drug in the body to the concentration of a drug in plasma | |
| 33. |
For the calculation of the volume of distribution (Vd) one must take into account: |
| A. | Concentration of substance in urine |
| B. | Therapeutical width of drug action |
| C. | A daily dose of drug |
| D. | Concentration of a substance in plasma |
| Answer» D. Concentration of a substance in plasma | |
| 34. |
……….. is a mathematical concept which describes a space in the body which a drug appears to occupy. |
| A. | Order of reaction |
| B. | Compartment |
| C. | Distribution |
| D. | Elimination |
| Answer» B. Compartment | |
| 35. |
………………..is the manner in which a drug is taken. |
| A. | Dosage regimen |
| B. | Dosage volume |
| C. | Dosage loading |
| D. | None of the above |
| Answer» A. Dosage regimen | |
| 36. |
…………………it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R. |
| A. | Accumulation Index |
| B. | Apparent volume of drug distribution |
| C. | Accumulation factor |
| D. | None of the above |
| Answer» A. Accumulation Index | |
| 37. |
………………… is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. |
| A. | Primary Dose |
| B. | Initial Dose |
| C. | Loading dose |
| D. | None of the above |
| Answer» C. Loading dose | |
| 38. |
The compartment models provide visual representation of various rate processes involved in drug disposition. Given statement is: |
| A. | False |
| B. | True |
| C. | Cannot say |
| D. | None of the above |
| Answer» B. True | |
| 39. |
...................is composed of highly perfused tissues, extracellular fluid, and blood with rapid and uniform drug distribution. |
| A. | Central compartment |
| B. | Peripheral compartment |
| C. | both of the above |
| D. | None of the above |
| Answer» A. Central compartment | |
| 40. |
……………composed of groups of tissues with lower blood perfusion and different affinity the drug with slow drug distribution. |
| A. | Central compartment |
| B. | Peripheral compartment |
| C. | Both of the above |
| D. | None of the above |
| Answer» B. Peripheral compartment | |
| 41. |
A multicompartment model assumes that all transfer rate processes for the passage of drug into or out of individual compartments are…………….. processes. |
| A. | First-order |
| B. | Second order |
| C. | Pseudo order |
| D. | None of the above |
| Answer» A. First-order | |
| 42. |
The multicompartment models are intended to provide……………. |
| A. | Therapeutic activity of the drug |
| B. | Achieve maximum efficacy |
| C. | Both of the above |
| D. | None of the above |
| Answer» C. Both of the above | |
| 43. |
The biological half-life of drug: |
| A. | is a constant physical property of the drug |
| B. | is a constant chemical property of the drug |
| C. | may be increased in patients with impaired renal failure |
| D. | may be decreased in patients by giving the drug by rapid I.V. injection |
| Answer» C. may be increased in patients with impaired renal failure | |
| 44. |
The half life of a drug eliminated by first order elimination kinetics will be longer in individuals who have an: |
| A. | increased volume of distribution or increased clearance |
| B. | increased volume of distribution or decreased clearance |
| C. | decreased volume of distribution or increased clearance |
| D. | decreased volume of distribution or decreased clearance |
| Answer» B. increased volume of distribution or decreased clearance | |
| 45. |
Half life (t1/2) is the time required to: |
| A. | change the amount of a drug in plasma by half during elimination |
| B. | metabolize a half of an introduced drug into the active metabolite |
| C. | absorb a half of an introduced drug |
| D. | bind a half of an introduced drug to plasma proteins |
| Answer» A. change the amount of a drug in plasma by half during elimination | |
| 46. |
Half life (t1/2) does not depend on: |
| A. | biotransformation |
| B. | time of drug absorption |
| C. | concentration of a drug in plasma |
| D. | rate of drug elimination |
| Answer» B. time of drug absorption | |
| 47. |
Elimination rate constant (Kelim) is defined by the following parameter: |
| A. | rate of absorption |
| B. | maximal concentration of a substance in plasma |
| C. | highest single dose |
| D. | half life (t1/2) |
| Answer» D. half life (t1/2) | |
| 48. |
Systemic clearance (Cl) is related with: |
| A. | only the concentration of substances in plasma |
| B. | only the elimination rate constant |
| C. | volume of distribution, half life and elimination rate constant |
| D. | bioavailability and half life |
| Answer» C. volume of distribution, half life and elimination rate constant | |
| 49. |
Biological Half life equation for first order process is |
| A. | t1/2 = a/2K |
| B. | t1/2 = 0.693/K |
| C. | ) t1/2 = 1/aK |
| D. | ) t1/2 = 3/2 K |
| Answer» B. t1/2 = 0.693/K | |
| 50. |
The area under the serum concentration time curve of the drug represents: |
| A. | the biological half life of the drug |
| B. | the amount of drug in the original dosage form |
| C. | The amount of drug absorbed |
| D. | The amount of drug excreted in the urine |
| Answer» C. The amount of drug absorbed | |
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