McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 1. |
The process by which molecules diffuse from a region of higher concentration to a region of lower concentration and no external energy is expended is called |
| A. | Passive diffusion |
| B. | Active transport |
| C. | Pore transport |
| D. | Facilitation diffusion |
| Answer» A. Passive diffusion | |
| 2. |
Which law states that 'the rate of diffusion is proportional to both the surface area and concentration difference and is inversely proportional to the thickness of the membrane’? |
| A. | Fick's Law |
| B. | Avagadro's Law |
| C. | Hooke's Law |
| D. | Pascal's Law |
| Answer» A. Fick's Law | |
| 3. |
Which of the following is a not mechanism of drug absorption through GIT |
| A. | Pore transport |
| B. | Active transport |
| C. | Endocytosis |
| D. | Metastasis |
| Answer» D. Metastasis | |
| 4. |
The process of engulfing of particulate material is called |
| A. | Pinocytosis |
| B. | Phagocytosis |
| C. | Convective transport |
| D. | Facilitated diffusion |
| Answer» B. Phagocytosis | |
| 5. |
Which of the following process is also called "cell drinking"? |
| A. | Pinocytosis |
| B. | Phagocytosis |
| C. | Convective transport |
| D. | Active tr |
| Answer» A. Pinocytosis | |
| 6. |
The absorption of drugs like (quaternary ammonium compounds, sulphonic acid) are explained by |
| A. | Ion pair transport |
| B. | convective transport |
| C. | active transport |
| D. | Facilitated diffusion |
| Answer» A. Ion pair transport | |
| 7. |
Fick's law is used for study of |
| A. | Dissolution rate |
| B. | Disintegration rate |
| C. | Dissociation rate |
| D. | Diffusion rate |
| Answer» D. Diffusion rate | |
| 8. |
The delivery of a drug through the skin is known as |
| A. | Sublingual |
| B. | Transdermal |
| C. | Inhalation |
| D. | Buccal |
| Answer» B. Transdermal | |
| 9. |
Which route of drug administration shows 100% Bioavailability? |
| A. | Oral |
| B. | Intravenous |
| C. | Rectal |
| D. | Topical |
| Answer» B. Intravenous | |
| 10. |
If drug administered by Intravenous route appears in feaces, it implies that the drug |
| A. | Undergo first pass metabolism |
| B. | Undergoes enterohepatic recycling |
| C. | It is not completely absorbed |
| D. | It is not completely metabolized |
| Answer» B. Undergoes enterohepatic recycling | |
| 11. |
Which of the following is characteristic of the oral route? |
| A. | Absorption depends on GI tract secretion and motor function |
| B. | Fast onset of effect |
| C. | A drug reaches the blood passing the liver |
| D. | The sterilization of medicinal forms is obligatory |
| Answer» A. Absorption depends on GI tract secretion and motor function | |
| 12. |
When the active transport system become saturated, the rate process become |
| A. | Zero order |
| B. | Second order |
| C. | Pseudo first order |
| D. | Pseudo zero order |
| Answer» A. Zero order | |
| 13. |
Rate of absorption of drug by passive diffusion is maximum in |
| A. | Small intestine |
| B. | Large intestine |
| C. | Stomach |
| D. | Oesphagus |
| Answer» A. Small intestine | |
| 14. |
Maximum movement of drug across the membrane occurs by |
| A. | Completely ionised |
| B. | Unionised |
| C. | Partially ionised |
| D. | None of them |
| Answer» B. Unionised | |
| 15. |
If drug has pKa value of 3 then at pH value of 7 what would be the degree of ionisation of the drug? |
| A. | Majority portion would be ionised |
| B. | Majority portion would be unionised |
| C. | Approximately 50% would be ionised and 50% unionised |
| D. | None of the above |
| Answer» A. Majority portion would be ionised | |
| 16. |
Which of the following is not the characteristic of the carrier mediated transport system? |
| A. | Energy dependent |
| B. | Reach equilibrium |
| C. | Metabolically inhibited |
| D. | Structurally specific and saturable |
| Answer» B. Reach equilibrium | |
| 17. |
Which of the following is alimentary route of administration when passage of drug through liver is minimized? |
| A. | Oral |
| B. | Transdermal |
| C. | Rectal |
| D. | Intraduodenal |
| Answer» C. Rectal | |
| 18. |
………………is the process of movement of unchanged drug from the site of administration to the systemic circulation. |
| A. | Absorption |
| B. | Dissolution |
| C. | Distribution |
| D. | Elimination |
| Answer» A. Absorption | |
| 19. |
Energy is utilized in ………………… diffusion mechanism. |
| A. | Passive |
| B. | Active |
| C. | Pore |
| D. | Cellular |
| Answer» B. Active | |
| 20. |
……………… involves the engulfment of small molecules or fluid. |
| A. | Endocytosis |
| B. | Pinocytosis |
| C. | Phagocytosis |
| D. | None of the above |
| Answer» B. Pinocytosis | |
| 21. |
The concentration of drug in blood or plasma will be comparatively in the GI tract. |
| A. | High |
| B. | Low |
| C. | Very High |
| D. | Very Low |
| Answer» A. High | |
| 22. |
................mechanism is useful to describe charged or highly ionized drug molecules. |
| A. | Ion-pair transport |
| B. | Cellular transport |
| C. | Active transport |
| D. | Passive tr |
| Answer» A. Ion-pair transport | |
| 23. |
To avoid bioavailability issues, the drug must have a minimum aqueous solubility of |
| A. | 150% |
| B. | 10% |
| C. | 100% |
| D. | 1% |
| Answer» D. 1% | |
| 24. |
When the solvent molecules are entrapped in the crystalline structure of the polymorph, it is called as |
| A. | Pseudo-polymorphism |
| B. | Amorphism |
| C. | Crystallinity |
| D. | All of the above |
| Answer» A. Pseudo-polymorphism | |
| 25. |
The occurrence of food in the GI tract can affect the drug bioavailability from an oral drug product. The above give statement is? |
| A. | True |
| B. | False |
| C. | Both of the above |
| D. | None of the above |
| Answer» A. True | |
| 26. |
The order of dissolution and absorption for different solid dosage forms is |
| A. | Stable > Amorphous > meta-stable |
| B. | Amorphous > meta-stable > stable |
| C. | Meta-stable > stable > Amorphous |
| D. | None of the above |
| Answer» B. Amorphous > meta-stable > stable | |
| 27. |
According to pH partition theory, a weak acidic drug will most likely be absorbed from the stomach because the drug which exists primarily in the…………. |
| A. | un-ionised, more lipid soluble form |
| B. | ionised, more water soluble form |
| C. | form of weak acid and more soluble in acid media |
| D. | ionic form of the drug which facilitates diffusion |
| Answer» A. un-ionised, more lipid soluble form | |
| 28. |
Noyes and Whitney equation is used to describe____________ |
| A. | Absorption |
| B. | Dissolution |
| C. | Distribution |
| D. | Disintegration |
| Answer» B. Dissolution | |
| 29. |
Amorphous forms of drugs are |
| A. | less soluble than crystal forms |
| B. | more soluble than crystal forms |
| C. | also called solvates |
| D. | practically insoluble |
| Answer» B. more soluble than crystal forms | |
| 30. |
Which of the following forms inclusion complex and improves aqueous solubility and dissolution rate? |
| A. | Cyclodextrins |
| B. | PEG |
| C. | PVT |
| D. | Poloxamer |
| Answer» A. Cyclodextrins | |
| 31. |
Drugs undergoing first pass metabolism are advised not to be administered through |
| A. | Oral route |
| B. | Rectal route |
| C. | Parenteral route |
| D. | Tr |
| Answer» D. Tr | |
| 32. |
When the solvent in association with the drug is water, the solvate is known as |
| A. | anhydrate |
| B. | amorphous |
| C. | hydrate |
| D. | none of the above |
| Answer» C. hydrate | |
| 33. |
………….is used to study gastric emptying. |
| A. | Barium sulphate |
| B. | Aluminum sulphate |
| C. | Calcium sulphate |
| D. | Aluminum hydroxide |
| Answer» A. Barium sulphate | |
| 34. |
The main mechanism of most drugs absorption in GI tract is: |
| A. | Active transport (carrier-mediated diffusion) |
| B. | Filtration (aqueous diffusion) |
| C. | Endocytosis and exocytosis |
| D. | Passive diffusion (lipid diffusion) |
| Answer» D. Passive diffusion (lipid diffusion) | |
| 35. |
Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized: |
| A. | Oral |
| B. | Transdermal |
| C. | Rectal |
| D. | Intraduodenal |
| Answer» C. Rectal | |
| 36. |
What is characteristic of the oral route? |
| A. | Fast onset of effect |
| B. | Absorption depends on GI tract secretion and motor function |
| C. | A drug reaches the blood passing the liver |
| D. | The sterilization of medicinal forms is obligatory |
| Answer» B. Absorption depends on GI tract secretion and motor function | |
| 37. |
Tick the feature of the sublingual route: |
| A. | Pretty fast absorption |
| B. | A drug is exposed to gastric secretion |
| C. | A drug is exposed more prominent liver metabolism |
| D. | A drug can be administered in a variety of doses |
| Answer» A. Pretty fast absorption | |
| 38. |
Pick out the parenteral route of medicinal agent administration: |
| A. | Rectal |
| B. | Oral |
| C. | Sublingual |
| D. | Inhalation |
| Answer» D. Inhalation | |
| 39. |
Parenteral administration: |
| A. | Cannot be used with unconsciousness patients |
| B. | Generally results in a less accurate dosage than oral administration |
| C. | Usually produces a more rapid response than oral administration |
| D. | Is too slow for emergency use |
| Answer» C. Usually produces a more rapid response than oral administration | |
| 40. |
What is characteristic of the intramuscular route of drug administration? |
| A. | Only water solutions can be injected |
| B. | Oily solutions can be injected |
| C. | Opportunity of hypertonic solution injections |
| D. | The action develops slower, than at oral administration |
| Answer» B. Oily solutions can be injected | |
| 41. |
All are characteristics of passive diffusion except |
| A. | Drugs moves down the concentration gradient. |
| B. | It is an energy independent process |
| C. | Drugs moves up the concentration gradient. |
| D. | It is non saturable process |
| Answer» C. Drugs moves up the concentration gradient. | |
| 42. |
Passive diffusion is expressed by |
| A. | Fick's first law of diffusion |
| B. | Fick's second law of diffusion |
| C. | First order kinetics |
| D. | zero order kinetics |
| Answer» A. Fick's first law of diffusion | |
| 43. |
Aqueous filled pores present in cell membrane responsible for absorption of |
| A. | water insoluble molecules |
| B. | water soluble molecules |
| C. | both (a) and (b) |
| D. | None of the above |
| Answer» B. water soluble molecules | |
| 44. |
What kind of substances cannot permeate membranes by passive diffusion? |
| A. | Lipid-soluble |
| B. | Non-ionized substances |
| C. | Hydrophobic substances |
| D. | Hydrophilic substances |
| Answer» D. Hydrophilic substances | |
| 45. |
A hydrophilic medicinal agent has the following property: |
| A. | Low ability to penetrate through the cell membrane lipids |
| B. | Penetrate through membranes by means of endocytosis |
| C. | Easy permeation through the blood-brain barrier |
| D. | High reabsorption in renal tubules |
| Answer» A. Low ability to penetrate through the cell membrane lipids | |
| 46. |
What is implied by active transport? |
| A. | Transport of drugs through a membrane by means of diffusion |
| B. | Transport without energy consumption |
| C. | Engulf of drug by a cell membrane with a new vesicle formation |
| D. | Tr |
| Answer» A. Transport of drugs through a membrane by means of diffusion | |
| 47. |
The rate of diffusion of drug across biological membrane is |
| A. | Directly proportional to the concentration gradients |
| B. | Dependant on route of administration |
| C. | Indirectly proportional to membrane thickness |
| D. | None of the above |
| Answer» A. Directly proportional to the concentration gradients | |
| 48. |
Absorption of griseofulvin is…………… |
| A. | Dissolution rate limited |
| B. | Permeation rate limited |
| C. | Perfusion rate limited |
| D. | None of the above |
| Answer» A. Dissolution rate limited | |
| 49. |
Micronized form of drug absorbed fast because |
| A. | surface area increased |
| B. | viscosity increased |
| C. | angle of distribution increased |
| D. | none of the above |
| Answer» A. surface area increased | |
| 50. |
…………form of weakly acidic drug absorbed well in stomach |
| A. | ionized |
| B. | unionised |
| C. | both |
| D. | none of the above |
| Answer» B. unionised | |
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