It is defined as the distribution of a drug between plasma and the rest of the body after oral or parenteral dosing.

Related MCQs

• Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.
• To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?
• Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution.
• For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?
• The amount of drug in the body is directly proportional to the concentration of the drug in plasma.
• The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.
• The occurrence of food in the GI tract can affect the drug bioavailability from an oral drug product. The above give statement is?
• Bioavailability differences among oral formulations of a drug are most likely to occur if the drug
• The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution?
• If the drug Y bind with plasma albumin with 10 times more affinity than drug X. Which the given statement is true?