McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 1. |
Which process involve alteration of drug distribution |
| A. | Competitive binding |
| B. | Reduced plasma protein level |
| C. | Both |
| D. | None |
| Answer» C. Both | |
| 2. |
If drug have very small volume of distribution it is likely that the drug |
| A. | Has short biological half life |
| B. | Does not accumulate in various tissue and organ |
| C. | Not bioavailable |
| D. | will not be effective |
| Answer» B. Does not accumulate in various tissue and organ | |
| 3. |
If distribution of drug is slower than process of biotransformation and elimination |
| A. | It will cause high blood level of drug |
| B. | It will cause low blood level of drug |
| C. | Cause failure to attain diffusion equilibrium |
| D. | None of the above |
| Answer» C. Cause failure to attain diffusion equilibrium | |
| 4. |
If the drug Y bind with plasma albumin with 10 times more affinity than drug X. Which the given statement is true? |
| A. | Apparent volume of distribution of drug X decrease |
| B. | Free concentration of drug X in blood will be increase |
| C. | Apparent volume of distribution of drug Y decrease |
| D. | Toxicity of drug Y increase |
| Answer» B. Free concentration of drug X in blood will be increase | |
| 5. |
The distribution of drugs into the central nervous system (brain) usually depends on: |
| A. | Aqueous diffusion |
| B. | Lipid diffusion |
| C. | Active transport |
| D. | Facilitated tr |
| Answer» B. Lipid diffusion | |
| 6. |
Which of the following is most likely to be associated with a high apparent volume of distribution |
| A. | High hepatic extraction ratio |
| B. | Penetration across the blood:brain and blood:testes barriers |
| C. | Extensive binding to plasma protein |
| D. | Extensive binding to tissue constituents |
| Answer» D. Extensive binding to tissue constituents | |
| 7. |
The Initial distribution of drug into the tissue is determined chiefly by |
| A. | Rate of blood flow to tissue |
| B. | Plasma protein binding of drug |
| C. | Affinity for tissue |
| D. | Gastric emptying time |
| Answer» A. Rate of blood flow to tissue | |
| 8. |
Transfer of drug from plasma to tissue depends on |
| A. | Weight of tissue |
| B. | Blood perfusion rate of tissue |
| C. | Size of tissue |
| D. | All of the above |
| Answer» B. Blood perfusion rate of tissue | |
| 9. |
A hydrophilic medicinal agent has |
| A. | Low ability to penetrate through the cell membrane lipids |
| B. | Easy permeation through the blood-brain barrier |
| C. | Penetrate through membranes by means of endocytosis |
| D. | High reabsorption in renal tubules |
| Answer» A. Low ability to penetrate through the cell membrane lipids | |
| 10. |
Biological barriers include all except: |
| A. | Renal tubules |
| B. | Cell membranes |
| C. | Capillary walls |
| D. | Placenta |
| Answer» A. Renal tubules | |
| 11. |
Blood Brain Barrier is maximum permeable to |
| A. | Na+ |
| B. | C02 |
| C. | Cl |
| D. | K+ |
| Answer» B. C02 | |
| 12. |
If a CNS drug is extensively ionized at pH of blood it will |
| A. | Penetrate the blood brain barrier slowly |
| B. | Penetrate the blood brain barrier rapidly |
| C. | Not penetrate blood brain barrier |
| D. | Be eliminated slowly |
| Answer» A. Penetrate the blood brain barrier slowly | |
| 13. |
The rate of drug transport across a cell membrane by lipid diffusion depends on all of the following except |
| A. | Drug size (diffusion constant) |
| B. | Surface area of absorption |
| C. | Lipid partition coefficient |
| D. | Density of tr |
| Answer» A. Drug size (diffusion constant) | |
| 14. |
The formula to calculate half life (t1/2) is |
| A. | 0.693 *Vd / C1 |
| B. | 0.693 *Cl / Vd |
| C. | 0.693 / Cl * Vd |
| D. | 0.693 / Cl |
| Answer» A. 0.693 *Vd / C1 | |
| 15. |
The procedure of transporting a drug from the bloodstream to tissues is called as |
| A. | Absorption |
| B. | Dissolution |
| C. | Distribution |
| D. | Elimination |
| Answer» C. Distribution | |
| 16. |
…………..it represents the degree to which a drug is distributed in body tissue rather than |
| A. | Volume of distribution (YD) |
| B. | Effect of distribution |
| C. | Area of distribution |
| D. | None of the above |
| Answer» A. Volume of distribution (YD) | |
| 17. |
It is defined as the distribution of a drug between plasma and the rest of the body after oral or parenteral dosing. |
| A. | Volume of distribution (VD) |
| B. | Apparent volume of drug distribution |
| C. | Phagocytosis |
| D. | None of the above |
| Answer» B. Apparent volume of drug distribution | |
| 18. |
The drugs having molecular size …………..easily cross capillary membrane. |
| A. | <500-600d |
| B. | < 100-200 d |
| C. | <300-600d |
| D. | <90M600d |
| Answer» A. <500-600d | |
| 19. |
The concentration of drug in blood or plasma will be comparatively in the GI tract. |
| A. | High |
| B. | Low |
| C. | Very High |
| D. | Very Low |
| Answer» B. Low | |
| 20. |
Fat is act as reservoir for……………………… Drugs |
| A. | Highly water soluble |
| B. | Lower lipid soluble |
| C. | Highly lipid soluble |
| D. | Lower lipid soluble |
| Answer» C. Highly lipid soluble | |
| 21. |
Displacement is significant when, the displaced drug is more than protein bound. |
| A. | 50% |
| B. | 95% |
| C. | 10% |
| D. | 1% |
| Answer» B. 95% | |
| 22. |
……………is located at the sertoli-sertoli cell junction. |
| A. | Blood testis barrier |
| B. | Blood CSF barrier |
| C. | Blood cellular barrier |
| D. | All of the above |
| Answer» A. Blood testis barrier | |
| 23. |
The Binding Order of drug to tissue is………………… |
| A. | Kidney > Liver > Lungs > Muscle |
| B. | Muscle > Kidney > Lungs > Liver |
| C. | Liver > Kidney > Lungs > Muscle |
| D. | Liver > Lungs > Kidney > Muscle |
| Answer» C. Liver > Kidney > Lungs > Muscle | |
| 24. |
…………………in lipophilicity increases the extend of binding. |
| A. | Increase |
| B. | Decrease |
| C. | Constant |
| D. | None of the above |
| Answer» A. Increase | |
| 25. |
Protein binding of drugs helps to maintain ……………for absorption of drugs. |
| A. | non sink condition |
| B. | sink condition |
| C. | pKa |
| D. | none of the above |
| Answer» B. sink condition | |
| 26. |
The loading dose of a drug is based upon the |
| A. | time taken for complete elimination |
| B. | percentage of drug excreted unchanged in urine |
| C. | percentage of drug bound to plasma protein |
| D. | apparent volume of distribution and the desired drug concentration in plasma |
| Answer» D. apparent volume of distribution and the desired drug concentration in plasma | |
| 27. |
The volume of distribution of drugs is: |
| A. | An expression of total body volume |
| B. | A measure of total fluid volume |
| C. | A relationship between the total amount of drug in the body and the concentration of the drug in the blood |
| D. | Proportional to bioavailability of the drug |
| Answer» C. A relationship between the total amount of drug in the body and the concentration of the drug in the blood | |
| 28. |
The volume of distribution (Vd) relates: |
| A. | Single to a daily dose of an administered drug |
| B. | An administered dose to a body weight |
| C. | An unchanged drug reaching the systemic circulation |
| D. | The amount of a drug in the body to the concentration of a drug in plasma |
| Answer» D. The amount of a drug in the body to the concentration of a drug in plasma | |
| 29. |
Movement of drug across the membrane is called as |
| A. | Symport |
| B. | Antiport |
| C. | Drug transport |
| D. | Absorption |
| Answer» C. Drug transport | |
| 30. |
Which of the following is known as Tamoxifen binding site? |
| A. | Site I |
| B. | Site II |
| C. | Site III |
| D. | Site IV |
| Answer» D. Site IV | |
| 31. |
Which of the following drug selectively bound to extravascular tissues? |
| A. | Warfarin |
| B. | Diazepam |
| C. | Digitoxin |
| D. | Chloroquin |
| Answer» D. Chloroquin | |
| 32. |
Plasma Protein binding …………..the volume of distribution of drugs. |
| A. | increases |
| B. | decreases |
| C. | no change |
| D. | none of the above |
| Answer» B. decreases | |
| 33. |
Following intravenous administration, drugs are distributed fastest to: |
| A. | the skin, kidney, and brain |
| B. | the liver, kidney, and brain |
| C. | the liver, adipose, and brain |
| D. | the liver, kidney, and adipose |
| Answer» B. the liver, kidney, and brain | |
| 34. |
…………is the tight junction between sertoli cells. |
| A. | BBB |
| B. | placental barrier |
| C. | blood-testis barrier |
| D. | endothelial barrier |
| Answer» C. blood-testis barrier | |
| 35. |
Distribution is…………….. |
| A. | irreversible process |
| B. | dynamic equilibrium process |
| C. | Both (a) & (b) |
| D. | none of the above |
| Answer» B. dynamic equilibrium process | |
| 36. |
A drug reverses plasma-protein binding is often referred as…….. |
| A. | displacer |
| B. | solvate |
| C. | carrier substance |
| D. | protein hydrolysate |
| Answer» A. displacer | |
| 37. |
Primary binding site for albumin is ………………binding site. |
| A. | Warfarin |
| B. | Diazepam |
| C. | Digitoxin |
| D. | Tamoxifen |
| Answer» A. Warfarin | |
| 38. |
Which of the following strategies are widely used to improve or promote transport of drug to brain? |
| A. | Glycosylation |
| B. | Use of Mannitol |
| C. | Prodrug approach |
| D. | All of the above |
| Answer» D. All of the above | |
| 39. |
Acidic drug have |
| A. | Low Vd |
| B. | high Vd |
| C. | No Vd |
| D. | none of the above |
| Answer» A. Low Vd | |
| 40. |
Low molecular weight of drugs have |
| A. | Low Vd |
| B. | high Vd |
| C. | No Vd |
| D. | none of the above |
| Answer» B. high Vd | |
| 41. |
Water soluble drugs have |
| A. | Low Vd |
| B. | high Vd |
| C. | No Vd |
| D. | none of the above |
| Answer» A. Low Vd | |
| 42. |
Lipid soluble drugs have |
| A. | Low Vd |
| B. | high Vd |
| C. | No Vd |
| D. | none of the above |
| Answer» B. high Vd | |
| 43. |
Protein binding ……………the distribution of drugs. |
| A. | Decreases |
| B. | Increases |
| C. | No Change |
| D. | none of the above |
| Answer» A. Decreases | |
| 44. |
Which one of the following physicochemical property is more important for passive diffusion of drugs from the GIT? |
| A. | Partition coefficient |
| B. | Lipid solubility |
| C. | pH of GIT fluids |
| D. | dissolution constant |
| Answer» A. Partition coefficient | |
| 45. |
Drug permeation through BBB can be improved by……….. |
| A. | Glycosylation |
| B. | Mannitol |
| C. | Dihydropyridine redox system |
| D. | all of the above |
| Answer» D. all of the above | |
| 46. |
Which of the following drug diffuses readily into the brain? |
| A. | Penicillin |
| B. | Thiopental |
| C. | Dopamine |
| D. | all of the above |
| Answer» B. Thiopental | |
| 47. |
Drug distribution in an organ depends on………… |
| A. | Organ size |
| B. | Perfusion rate |
| C. | Partition Coefficient |
| D. | all of the above |
| Answer» D. all of the above | |
| 48. |
Protein binding of acidic drugs decreased in……….. |
| A. | Trauma |
| B. | Surgery |
| C. | Hepatic Cirrhosis |
| D. | Burns |
| Answer» A. Trauma | |
| 49. |
Which one of the following sentences will be the actual definition of distribution? |
| A. | Transfer of drug from the administration dosage to surrounding fluid |
| B. | Transfer of drug from the surrounding the fluid to the blood |
| C. | Transfer of the drug from the oral cavity to the intestine |
| D. | Reversible tr |
| Answer» D. Reversible tr | |
| 50. |
What should be the molecular weight of the drug molecules so that they can easily pass through the membrane? |
| A. | 600-800 Dalton |
| B. | 500-600 Dalton |
| C. | 300-500 Dalton |
| D. | 200-400 Dalton |
| Answer» B. 500-600 Dalton | |
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