McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
| 1. |
Liposomes are spherical structures, usually between in diameter…………….. |
| A. | 80nm-100nm |
| B. | 60nm-100nm |
| C. | 55nm-1000nm |
| D. | 15nm-1000nm |
| Answer» D. 15nm-1000nm | |
| 2. |
Liposomes consists of a bilayer of………………… |
| A. | Hydrophilic molecules |
| B. | Hydrophobic molecules |
| C. | Both a and b |
| D. | None |
| Answer» C. Both a and b | |
| 3. |
Liposomes have half-life ……………. |
| A. | Longer |
| B. | Shorter |
| C. | Intermediate |
| D. | Both a and b |
| Answer» B. Shorter | |
| 4. |
Liposome phospholipids undergoes ……………… |
| A. | Oxidation |
| B. | Hydrolysis |
| C. | Acetylation |
| D. | Both a and b |
| Answer» B. Hydrolysis | |
| 5. |
Intermediate sized unilamellar vesicles are prepared by |
| A. | Sonication |
| B. | High pressure extrusion technique |
| C. | Detergent dialysis |
| D. | Both b and c |
| Answer» D. Both b and c | |
| 6. |
The diameter of Small unilamellar vesicles is |
| A. | 20-100nm |
| B. | 20-1000nm |
| C. | 10-100nm |
| D. | 100nm-400nm |
| Answer» A. 20-100nm | |
| 7. |
Tranfersome belongs to the classification according to |
| A. | Composition |
| B. | Application |
| C. | Function |
| D. | None of the above |
| Answer» C. Function | |
| 8. |
Liposomes with ___________number of lamella are called as “pauci -lamellar liposomes”. |
| A. | Lower |
| B. | Higher |
| C. | Single |
| D. | None of the above |
| Answer» A. Lower | |
| 9. |
Passive Loading Technique includes………….. |
| A. | Lyophilization |
| B. | Proliposomes |
| C. | Solvent dispersion |
| D. | Both a and b |
| Answer» C. Solvent dispersion | |
| 10. |
Loading of the entrapped agents before/during the manufacture procedure is known as………… |
| A. | Active loading |
| B. | Passive loading |
| C. | Both a and b |
| D. | None of the above |
| Answer» B. Passive loading | |
| 11. |
Drawback of Lipid hydration method is |
| A. | Low internal volume |
| B. | High encapsulation efficiency |
| C. | Size distribution is homogenous |
| D. | None of the above |
| Answer» A. Low internal volume | |
| 12. |
Tip of sonicator is directly engrossed into liposome dispersion in…………… |
| A. | Bath sonication |
| B. | Probe sonication |
| C. | None of the above |
| D. | all |
| Answer» B. Probe sonication | |
| 13. |
The resulting liposomes from French pressure cell extrusion are ______than sonicated SUVs. |
| A. | Smaller |
| B. | Equal |
| C. | Larger |
| D. | all |
| Answer» C. Larger | |
| 14. |
To produce a microemulsion of small vesicles at least _______ circulations are required |
| A. | at least 20 circulation but not greater than 200 |
| B. | 10 circulations |
| C. | at least 200 circulation but not greater than 2000 |
| D. | at least 2 circulations but not greater than 10 |
| Answer» A. at least 20 circulation but not greater than 200 | |
| 15. |
Dried reconstituted vesicles method is performed in………….. |
| A. | Solvent dispersion |
| B. | Mechanical dispersion |
| C. | Both a and b |
| D. | none |
| Answer» B. Mechanical dispersion | |
| 16. |
Solvent vaporization is also known as…………………. |
| A. | Ether injection |
| B. | Ethanol injection |
| C. | Double emulsification |
| D. | Reverse-phase evaporation |
| Answer» A. Ether injection | |
| 17. |
Temperature used for Ether Injection method is______ or under reduced pressure. |
| A. | 15-25 ̊C |
| B. | 55-65 ̊C |
| C. | 55-85 ̊C |
| D. | None of the above |
| Answer» B. 55-65 ̊C | |
| 18. |
Ketoconazole liposomes are given by……………. |
| A. | Lungs |
| B. | Oral |
| C. | Transdermal |
| D. | Intravenous |
| Answer» C. Transdermal | |
| 19. |
Amphotericin B liposomes are given…………….. |
| A. | Lungs |
| B. | Oral |
| C. | Transdermal |
| D. | Intravenous |
| Answer» B. Oral | |
| 20. |
In niosomes phospholipids are ……………… |
| A. | Present |
| B. | Absent |
| C. | Both a or b |
| D. | None |
| Answer» A. Present | |
| 21. |
Pharmacosome belongs to the classification according to |
| A. | Composition |
| B. | Function |
| C. | Application |
| D. | None of the above |
| Answer» B. Function | |
| 22. |
Which of the following can be incorporated into a liposome? |
| A. | Only drugs and viruses |
| B. | Only Peptides and viruses due to similar characteristics |
| C. | Only viruses |
| D. | Drugs, peptides, viruses, bacteria |
| Answer» D. Drugs, peptides, viruses, bacteria | |
| 23. |
How are MLV liposomes made? |
| A. | 2-10 bilayers of lipid |
| B. | Series of concentric bilayers of lipid |
| C. | The single bilayer of lipid |
| D. | 100 bilayer of lipid |
| Answer» B. Series of concentric bilayers of lipid | |
| 24. |
How are OLV liposomes made? |
| A. | 2-10 bilayers of lipid |
| B. | Series of concentric bilayers of lipid |
| C. | A single bilayer of lipid |
| D. | 100 bilayer of lipid |
| Answer» A. 2-10 bilayers of lipid | |
| 25. |
Which of the following is a characteristic of the parental controlled drug release system by liposomes? |
| A. | Free flowing powders |
| B. | Aqueous solutions |
| C. | Lipid bilayer enclosing the drug |
| D. | Administration of emulsions |
| Answer» C. Lipid bilayer enclosing the drug | |
| 26. |
Which of the following drugs can not be given as transdermal administration? |
| A. | Drugs with very short half life |
| B. | Drugs with narrow therapeutic index |
| C. | Easy removal and termination |
| D. | Drug against peptic ulcer |
| Answer» D. Drug against peptic ulcer | |
| 27. |
What are the characteristics of the monolithic devices? |
| A. | The drug has a large therapeutic index |
| B. | Aqueous solution |
| C. | Control drug release by partitioning the drug from oil |
| D. | Administration of emulsion |
| Answer» A. The drug has a large therapeutic index | |
| 28. |
Which of the following characteristics is suitable for transdermal drug? |
| A. | Large drug dose |
| B. | Large molecular size |
| C. | Drugs with narrow therapeutic index |
| D. | Drug which are metabolized in the skin |
| Answer» C. Drugs with narrow therapeutic index | |
| 29. |
The rate at which monolithic devices transfer drug the patient body is proportional to________ of time. |
| A. | Square of time |
| B. | The square root of time |
| C. | Twice the time |
| D. | Half the time |
| Answer» B. The square root of time | |
| 30. |
What are the characteristics of the reservoir or membrane devices? |
| A. | The drug has a large therapeutic index |
| B. | Drug permeation rate is high |
| C. | Control drug release by partitioning the drug from oil |
| D. | Administration of emulsion |
| Answer» B. Drug permeation rate is high | |
| 31. |
What are the characteristics of the mixed monolithic reservoir devices? |
| A. | The drug has a large therapeutic index |
| B. | Drug permeation rate is high |
| C. | The drug polymer matrix is layered by rate controlling membrane |
| D. | Administration of emulsion |
| Answer» C. The drug polymer matrix is layered by rate controlling membrane | |
| 32. |
Which of the following is false in regarding reservoir devices? |
| A. | These devices are used when the drug permeation rate is rapid |
| B. | The release of the drug is controlled |
| C. | Suitable for low therapeutic index |
| D. | The drug is contained in a powder from floating on liquid |
| Answer» D. The drug is contained in a powder from floating on liquid | |
| 33. |
Which of the following is true for monolithic devices? |
| A. | These devices are used when the drug permeation rate is rapid |
| B. | The release of the drug is controlled |
| C. | Suitable for drugs with large therapeutic index |
| D. | The drug is contained in a powder form floating on liquid |
| Answer» C. Suitable for drugs with large therapeutic index | |
| 34. |
The absorption of the ophthalmic drug does not depend on which of the following? |
| A. | Physicochemical properties of permeating molecule |
| B. | Drainage of tears |
| C. | Output of tears |
| D. | Size of the eyeball |
| Answer» D. Size of the eyeball | |
| 35. |
Which of the following is false for monolithic devices? |
| A. | The drug used for these devices has large therapeutic index |
| B. | There are three categories of matrix devices |
| C. | 1st type has the drug dissolved in the polymer matrix |
| D. | 2nd type has drug delivery |
| Answer» B. There are three categories of matrix devices | |
| 36. |
Problems with opioid TDDS include. |
| A. | Poor patient compliance |
| B. | Allergy |
| C. | Constipation. |
| D. | Respiratory depression. |
| Answer» B. Allergy | |
| 37. |
Regarding the skin: |
| A. | The epidermis is the thickest layer. |
| B. | The stratum corneum is the greatest barrier to transdermal transport. |
| C. | The dermis has a rich capillary blood supply. |
| D. | Skin hydration is a cause of inter-individual variation in drug absorption. |
| Answer» D. Skin hydration is a cause of inter-individual variation in drug absorption. | |
| 38. |
How much thickness of the dermis layer? |
| A. | 2 to 7 nm |
| B. | 3 to 5 nm |
| C. | 3 to 6 nm |
| D. | 5 to 8 nm |
| Answer» B. 3 to 5 nm | |
| 39. |
TDDS is usually only suitable for drugs of what level of potency? |
| A. | Typically only for drugs of high potency. |
| B. | Low potency |
| C. | High to low potency |
| D. | Low to high potency |
| Answer» A. Typically only for drugs of high potency. | |
| 40. |
In the use of TDDS for drug application ? size has to be considered reasonable? |
| A. | Strip size |
| B. | Patch size |
| C. | Film size |
| D. | Diskette size |
| Answer» B. Patch size | |
| 41. |
What is the largest organ of the body? |
| A. | Liver |
| B. | Lungs |
| C. | Skin |
| D. | Brain |
| Answer» C. Skin | |
| 42. |
Which of the following is false for Merits of the TDDS. |
| A. | Avoidance of the First pass effect |
| B. | A stable and controlled blood level |
| C. | Termination at any time is conceivable |
| D. | Skin irritation and allergic response |
| Answer» D. Skin irritation and allergic response | |
| 43. |
How many layer are seen in monolithic TDDS design? |
| A. | 4 |
| B. | 3 |
| C. | 5 |
| D. | 2 |
| Answer» B. 3 | |
| 44. |
How many layer are seen in membrane-controlled system? |
| A. | 3 |
| B. | 5 |
| C. | 4 |
| D. | 6 |
| Answer» C. 4 | |
| 45. |
A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field. |
| A. | Iontophoresis |
| B. | Sonophoresis |
| C. | Electrophoresis |
| D. | Ion exchange |
| Answer» A. Iontophoresis | |
| 46. |
A physical method of permeation enhancement that involves the use of high frequency ultrasound. It is thought to influence the integrity of the SC and thus affect its penetrability. |
| A. | Iontophoresis |
| B. | Sonophoresis |
| C. | Electrophoresis |
| D. | Ion exchange |
| Answer» B. Sonophoresis | |
| 47. |
Which component are not included in combination of the SEDDS formulation? |
| A. | Oil |
| B. | Lipid |
| C. | Drug |
| D. | Wax |
| Answer» D. Wax | |
| 48. |
SEDDSs emulsify spontaneously to produce fine oil in water emulsions when introduced into an aqueous phase under gentle agitation and spread readily in the____________. |
| A. | GIT |
| B. | RT |
| C. | UT |
| D. | Liver |
| Answer» A. GIT | |
| 49. |
SEDDSs produce emulsion with droplet size between ____________. |
| A. | 200 to 400nm |
| B. | 100 to 300nm |
| C. | 10 to 100nm |
| D. | 1000nm |
| Answer» B. 100 to 300nm | |
| 50. |
Self micro emulsifying drug delivery systems (SMEDDSs) form transparent micro emulsions with droplet size of less than__________. |
| A. | 50 nm |
| B. | 70 nm |
| C. | 100 nm |
| D. | 200 nm |
| Answer» A. 50 nm | |
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