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110+ Current Advances of Novel Drug Delivery System Solved MCQs

These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .

1.

Liposomes are spherical structures, usually between in diameter……………..

A. 80nm-100nm
B. 60nm-100nm
C. 55nm-1000nm
D. 15nm-1000nm
Answer» D. 15nm-1000nm
2.

Liposomes consists of a bilayer of…………………

A. Hydrophilic molecules
B. Hydrophobic molecules
C. Both a and b
D. None
Answer» C. Both a and b
3.

Liposomes have half-life …………….

A. Longer
B. Shorter
C. Intermediate
D. Both a and b
Answer» B. Shorter
4.

Liposome phospholipids undergoes ………………

A. Oxidation
B. Hydrolysis
C. Acetylation
D. Both a and b
Answer» B. Hydrolysis
5.

Intermediate sized unilamellar vesicles are prepared by

A. Sonication
B. High pressure extrusion technique
C. Detergent dialysis
D. Both b and c
Answer» D. Both b and c
6.

The diameter of Small unilamellar vesicles is

A. 20-100nm
B. 20-1000nm
C. 10-100nm
D. 100nm-400nm
Answer» A. 20-100nm
7.

Tranfersome belongs to the classification according to

A. Composition
B. Application
C. Function
D. None of the above
Answer» C. Function
8.

Liposomes with ___________number of lamella are called as “pauci -lamellar liposomes”.

A. Lower
B. Higher
C. Single
D. None of the above
Answer» A. Lower
9.

Passive Loading Technique includes…………..

A. Lyophilization
B. Proliposomes
C. Solvent dispersion
D. Both a and b
Answer» C. Solvent dispersion
10.

Loading of the entrapped agents before/during the manufacture procedure is known as…………

A. Active loading
B. Passive loading
C. Both a and b
D. None of the above
Answer» B. Passive loading
11.

Drawback of Lipid hydration method is

A. Low internal volume
B. High encapsulation efficiency
C. Size distribution is homogenous
D. None of the above
Answer» A. Low internal volume
12.

Tip of sonicator is directly engrossed into liposome dispersion in……………

A. Bath sonication
B. Probe sonication
C. None of the above
D. all
Answer» B. Probe sonication
13.

The resulting liposomes from French pressure cell extrusion are ______than sonicated SUVs.

A. Smaller
B. Equal
C. Larger
D. all
Answer» C. Larger
14.

To produce a microemulsion of small vesicles at least _______ circulations are required

A. at least 20 circulation but not greater than 200
B. 10 circulations
C. at least 200 circulation but not greater than 2000
D. at least 2 circulations but not greater than 10
Answer» A. at least 20 circulation but not greater than 200
15.

Dried reconstituted vesicles method is performed in…………..

A. Solvent dispersion
B. Mechanical dispersion
C. Both a and b
D. none
Answer» B. Mechanical dispersion
16.

Solvent vaporization is also known as………………….

A. Ether injection
B. Ethanol injection
C. Double emulsification
D. Reverse-phase evaporation
Answer» A. Ether injection
17.

Temperature used for Ether Injection method is______ or under reduced pressure.

A. 15-25 ̊C
B. 55-65 ̊C
C. 55-85 ̊C
D. None of the above
Answer» B. 55-65 ̊C
18.

Ketoconazole liposomes are given by…………….

A. Lungs
B. Oral
C. Transdermal
D. Intravenous
Answer» C. Transdermal
19.

Amphotericin B liposomes are given……………..

A. Lungs
B. Oral
C. Transdermal
D. Intravenous
Answer» B. Oral
20.

In niosomes phospholipids are ………………

A. Present
B. Absent
C. Both a or b
D. None
Answer» A. Present
21.

Pharmacosome belongs to the classification according to

A. Composition
B. Function
C. Application
D. None of the above
Answer» B. Function
22.

Which of the following can be incorporated into a liposome?

A. Only drugs and viruses
B. Only Peptides and viruses due to similar characteristics
C. Only viruses
D. Drugs, peptides, viruses, bacteria
Answer» D. Drugs, peptides, viruses, bacteria
23.

How are MLV liposomes made?

A. 2-10 bilayers of lipid
B. Series of concentric bilayers of lipid
C. The single bilayer of lipid
D. 100 bilayer of lipid
Answer» B. Series of concentric bilayers of lipid
24.

How are OLV liposomes made?

A. 2-10 bilayers of lipid
B. Series of concentric bilayers of lipid
C. A single bilayer of lipid
D. 100 bilayer of lipid
Answer» A. 2-10 bilayers of lipid
25.

Which of the following is a characteristic of the parental controlled drug release system by liposomes?

A. Free flowing powders
B. Aqueous solutions
C. Lipid bilayer enclosing the drug
D. Administration of emulsions
Answer» C. Lipid bilayer enclosing the drug
26.

Which of the following drugs can not be given as transdermal administration?

A. Drugs with very short half life
B. Drugs with narrow therapeutic index
C. Easy removal and termination
D. Drug against peptic ulcer
Answer» D. Drug against peptic ulcer
27.

What are the characteristics of the monolithic devices?

A. The drug has a large therapeutic index
B. Aqueous solution
C. Control drug release by partitioning the drug from oil
D. Administration of emulsion
Answer» A. The drug has a large therapeutic index
28.

Which of the following characteristics is suitable for transdermal drug?

A. Large drug dose
B. Large molecular size
C. Drugs with narrow therapeutic index
D. Drug which are metabolized in the skin
Answer» C. Drugs with narrow therapeutic index
29.

The rate at which monolithic devices transfer drug the patient body is proportional to________ of time.

A. Square of time
B. The square root of time
C. Twice the time
D. Half the time
Answer» B. The square root of time
30.

What are the characteristics of the reservoir or membrane devices?

A. The drug has a large therapeutic index
B. Drug permeation rate is high
C. Control drug release by partitioning the drug from oil
D. Administration of emulsion
Answer» B. Drug permeation rate is high
31.

What are the characteristics of the mixed monolithic reservoir devices?

A. The drug has a large therapeutic index
B. Drug permeation rate is high
C. The drug polymer matrix is layered by rate controlling membrane
D. Administration of emulsion
Answer» C. The drug polymer matrix is layered by rate controlling membrane
32.

Which of the following is false in regarding reservoir devices?

A. These devices are used when the drug permeation rate is rapid
B. The release of the drug is controlled
C. Suitable for low therapeutic index
D. The drug is contained in a powder from floating on liquid
Answer» D. The drug is contained in a powder from floating on liquid
33.

Which of the following is true for monolithic devices?

A. These devices are used when the drug permeation rate is rapid
B. The release of the drug is controlled
C. Suitable for drugs with large therapeutic index
D. The drug is contained in a powder form floating on liquid
Answer» C. Suitable for drugs with large therapeutic index
34.

The absorption of the ophthalmic drug does not depend on which of the following?

A. Physicochemical properties of permeating molecule
B. Drainage of tears
C. Output of tears
D. Size of the eyeball
Answer» D. Size of the eyeball
35.

Which of the following is false for monolithic devices?

A. The drug used for these devices has large therapeutic index
B. There are three categories of matrix devices
C. 1st type has the drug dissolved in the polymer matrix
D. 2nd type has drug delivery
Answer» B. There are three categories of matrix devices
36.

Problems with opioid TDDS include.

A. Poor patient compliance
B. Allergy
C. Constipation.
D. Respiratory depression.
Answer» B. Allergy
37.

Regarding the skin:

A. The epidermis is the thickest layer.
B. The stratum corneum is the greatest barrier to transdermal transport.
C. The dermis has a rich capillary blood supply.
D. Skin hydration is a cause of inter-individual variation in drug absorption.
Answer» D. Skin hydration is a cause of inter-individual variation in drug absorption.
38.

How much thickness of the dermis layer?

A. 2 to 7 nm
B. 3 to 5 nm
C. 3 to 6 nm
D. 5 to 8 nm
Answer» B. 3 to 5 nm
39.

TDDS is usually only suitable for drugs of what level of potency?

A. Typically only for drugs of high potency.
B. Low potency
C. High to low potency
D. Low to high potency
Answer» A. Typically only for drugs of high potency.
40.

In the use of TDDS for drug application ? size has to be considered reasonable?

A. Strip size
B. Patch size
C. Film size
D. Diskette size
Answer» B. Patch size
41.

What is the largest organ of the body?

A. Liver
B. Lungs
C. Skin
D. Brain
Answer» C. Skin
42.

Which of the following is false for Merits of the TDDS.

A. Avoidance of the First pass effect
B. A stable and controlled blood level
C. Termination at any time is conceivable
D. Skin irritation and allergic response
Answer» D. Skin irritation and allergic response
43.

How many layer are seen in monolithic TDDS design?

A. 4
B. 3
C. 5
D. 2
Answer» B. 3
44.

How many layer are seen in membrane-controlled system?

A. 3
B. 5
C. 4
D. 6
Answer» C. 4
45.

A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field.

A. Iontophoresis
B. Sonophoresis
C. Electrophoresis
D. Ion exchange
Answer» A. Iontophoresis
46.

A physical method of permeation enhancement that involves the use of high frequency ultrasound. It is thought to influence the integrity of the SC and thus affect its penetrability.

A. Iontophoresis
B. Sonophoresis
C. Electrophoresis
D. Ion exchange
Answer» B. Sonophoresis
47.

Which component are not included in combination of the SEDDS formulation?

A. Oil
B. Lipid
C. Drug
D. Wax
Answer» D. Wax
48.

SEDDSs emulsify spontaneously to produce fine oil in water emulsions when introduced into an aqueous phase under gentle agitation and spread readily in the____________.

A. GIT
B. RT
C. UT
D. Liver
Answer» A. GIT
49.

SEDDSs produce emulsion with droplet size between ____________.

A. 200 to 400nm
B. 100 to 300nm
C. 10 to 100nm
D. 1000nm
Answer» B. 100 to 300nm
50.

Self micro emulsifying drug delivery systems (SMEDDSs) form transparent micro emulsions with droplet size of less than__________.

A. 50 nm
B. 70 nm
C. 100 nm
D. 200 nm
Answer» A. 50 nm

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