

McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
1. |
Liposomes are spherical structures, usually between in diameter…………….. |
A. | 80nm-100nm |
B. | 60nm-100nm |
C. | 55nm-1000nm |
D. | 15nm-1000nm |
Answer» D. 15nm-1000nm |
2. |
Liposomes consists of a bilayer of………………… |
A. | Hydrophilic molecules |
B. | Hydrophobic molecules |
C. | Both a and b |
D. | None |
Answer» C. Both a and b |
3. |
Liposomes have half-life ……………. |
A. | Longer |
B. | Shorter |
C. | Intermediate |
D. | Both a and b |
Answer» B. Shorter |
4. |
Liposome phospholipids undergoes ……………… |
A. | Oxidation |
B. | Hydrolysis |
C. | Acetylation |
D. | Both a and b |
Answer» B. Hydrolysis |
5. |
Intermediate sized unilamellar vesicles are prepared by |
A. | Sonication |
B. | High pressure extrusion technique |
C. | Detergent dialysis |
D. | Both b and c |
Answer» D. Both b and c |
6. |
The diameter of Small unilamellar vesicles is |
A. | 20-100nm |
B. | 20-1000nm |
C. | 10-100nm |
D. | 100nm-400nm |
Answer» A. 20-100nm |
7. |
Tranfersome belongs to the classification according to |
A. | Composition |
B. | Application |
C. | Function |
D. | None of the above |
Answer» C. Function |
8. |
Liposomes with ___________number of lamella are called as “pauci -lamellar liposomes”. |
A. | Lower |
B. | Higher |
C. | Single |
D. | None of the above |
Answer» A. Lower |
9. |
Passive Loading Technique includes………….. |
A. | Lyophilization |
B. | Proliposomes |
C. | Solvent dispersion |
D. | Both a and b |
Answer» C. Solvent dispersion |
10. |
Loading of the entrapped agents before/during the manufacture procedure is known as………… |
A. | Active loading |
B. | Passive loading |
C. | Both a and b |
D. | None of the above |
Answer» B. Passive loading |
11. |
Drawback of Lipid hydration method is |
A. | Low internal volume |
B. | High encapsulation efficiency |
C. | Size distribution is homogenous |
D. | None of the above |
Answer» A. Low internal volume |
12. |
Tip of sonicator is directly engrossed into liposome dispersion in…………… |
A. | Bath sonication |
B. | Probe sonication |
C. | None of the above |
D. | all |
Answer» B. Probe sonication |
13. |
The resulting liposomes from French pressure cell extrusion are ______than sonicated SUVs. |
A. | Smaller |
B. | Equal |
C. | Larger |
D. | all |
Answer» C. Larger |
14. |
To produce a microemulsion of small vesicles at least _______ circulations are required |
A. | at least 20 circulation but not greater than 200 |
B. | 10 circulations |
C. | at least 200 circulation but not greater than 2000 |
D. | at least 2 circulations but not greater than 10 |
Answer» A. at least 20 circulation but not greater than 200 |
15. |
Dried reconstituted vesicles method is performed in………….. |
A. | Solvent dispersion |
B. | Mechanical dispersion |
C. | Both a and b |
D. | none |
Answer» B. Mechanical dispersion |
16. |
Solvent vaporization is also known as…………………. |
A. | Ether injection |
B. | Ethanol injection |
C. | Double emulsification |
D. | Reverse-phase evaporation |
Answer» A. Ether injection |
17. |
Temperature used for Ether Injection method is______ or under reduced pressure. |
A. | 15-25 ̊C |
B. | 55-65 ̊C |
C. | 55-85 ̊C |
D. | None of the above |
Answer» B. 55-65 ̊C |
18. |
Ketoconazole liposomes are given by……………. |
A. | Lungs |
B. | Oral |
C. | Transdermal |
D. | Intravenous |
Answer» C. Transdermal |
19. |
Amphotericin B liposomes are given…………….. |
A. | Lungs |
B. | Oral |
C. | Transdermal |
D. | Intravenous |
Answer» B. Oral |
20. |
In niosomes phospholipids are ……………… |
A. | Present |
B. | Absent |
C. | Both a or b |
D. | None |
Answer» A. Present |
21. |
Pharmacosome belongs to the classification according to |
A. | Composition |
B. | Function |
C. | Application |
D. | None of the above |
Answer» B. Function |
22. |
Which of the following can be incorporated into a liposome? |
A. | Only drugs and viruses |
B. | Only Peptides and viruses due to similar characteristics |
C. | Only viruses |
D. | Drugs, peptides, viruses, bacteria |
Answer» D. Drugs, peptides, viruses, bacteria |
23. |
How are MLV liposomes made? |
A. | 2-10 bilayers of lipid |
B. | Series of concentric bilayers of lipid |
C. | The single bilayer of lipid |
D. | 100 bilayer of lipid |
Answer» B. Series of concentric bilayers of lipid |
24. |
How are OLV liposomes made? |
A. | 2-10 bilayers of lipid |
B. | Series of concentric bilayers of lipid |
C. | A single bilayer of lipid |
D. | 100 bilayer of lipid |
Answer» A. 2-10 bilayers of lipid |
25. |
Which of the following is a characteristic of the parental controlled drug release system by liposomes? |
A. | Free flowing powders |
B. | Aqueous solutions |
C. | Lipid bilayer enclosing the drug |
D. | Administration of emulsions |
Answer» C. Lipid bilayer enclosing the drug |
26. |
Which of the following drugs can not be given as transdermal administration? |
A. | Drugs with very short half life |
B. | Drugs with narrow therapeutic index |
C. | Easy removal and termination |
D. | Drug against peptic ulcer |
Answer» D. Drug against peptic ulcer |
27. |
What are the characteristics of the monolithic devices? |
A. | The drug has a large therapeutic index |
B. | Aqueous solution |
C. | Control drug release by partitioning the drug from oil |
D. | Administration of emulsion |
Answer» A. The drug has a large therapeutic index |
28. |
Which of the following characteristics is suitable for transdermal drug? |
A. | Large drug dose |
B. | Large molecular size |
C. | Drugs with narrow therapeutic index |
D. | Drug which are metabolized in the skin |
Answer» C. Drugs with narrow therapeutic index |
29. |
The rate at which monolithic devices transfer drug the patient body is proportional to________ of time. |
A. | Square of time |
B. | The square root of time |
C. | Twice the time |
D. | Half the time |
Answer» B. The square root of time |
30. |
What are the characteristics of the reservoir or membrane devices? |
A. | The drug has a large therapeutic index |
B. | Drug permeation rate is high |
C. | Control drug release by partitioning the drug from oil |
D. | Administration of emulsion |
Answer» B. Drug permeation rate is high |
31. |
What are the characteristics of the mixed monolithic reservoir devices? |
A. | The drug has a large therapeutic index |
B. | Drug permeation rate is high |
C. | The drug polymer matrix is layered by rate controlling membrane |
D. | Administration of emulsion |
Answer» C. The drug polymer matrix is layered by rate controlling membrane |
32. |
Which of the following is false in regarding reservoir devices? |
A. | These devices are used when the drug permeation rate is rapid |
B. | The release of the drug is controlled |
C. | Suitable for low therapeutic index |
D. | The drug is contained in a powder from floating on liquid |
Answer» D. The drug is contained in a powder from floating on liquid |
33. |
Which of the following is true for monolithic devices? |
A. | These devices are used when the drug permeation rate is rapid |
B. | The release of the drug is controlled |
C. | Suitable for drugs with large therapeutic index |
D. | The drug is contained in a powder form floating on liquid |
Answer» C. Suitable for drugs with large therapeutic index |
34. |
The absorption of the ophthalmic drug does not depend on which of the following? |
A. | Physicochemical properties of permeating molecule |
B. | Drainage of tears |
C. | Output of tears |
D. | Size of the eyeball |
Answer» D. Size of the eyeball |
35. |
Which of the following is false for monolithic devices? |
A. | The drug used for these devices has large therapeutic index |
B. | There are three categories of matrix devices |
C. | 1st type has the drug dissolved in the polymer matrix |
D. | 2nd type has drug delivery |
Answer» B. There are three categories of matrix devices |
36. |
Problems with opioid TDDS include. |
A. | Poor patient compliance |
B. | Allergy |
C. | Constipation. |
D. | Respiratory depression. |
Answer» B. Allergy |
37. |
Regarding the skin: |
A. | The epidermis is the thickest layer. |
B. | The stratum corneum is the greatest barrier to transdermal transport. |
C. | The dermis has a rich capillary blood supply. |
D. | Skin hydration is a cause of inter-individual variation in drug absorption. |
Answer» D. Skin hydration is a cause of inter-individual variation in drug absorption. |
38. |
How much thickness of the dermis layer? |
A. | 2 to 7 nm |
B. | 3 to 5 nm |
C. | 3 to 6 nm |
D. | 5 to 8 nm |
Answer» B. 3 to 5 nm |
39. |
TDDS is usually only suitable for drugs of what level of potency? |
A. | Typically only for drugs of high potency. |
B. | Low potency |
C. | High to low potency |
D. | Low to high potency |
Answer» A. Typically only for drugs of high potency. |
40. |
In the use of TDDS for drug application ? size has to be considered reasonable? |
A. | Strip size |
B. | Patch size |
C. | Film size |
D. | Diskette size |
Answer» B. Patch size |
41. |
What is the largest organ of the body? |
A. | Liver |
B. | Lungs |
C. | Skin |
D. | Brain |
Answer» C. Skin |
42. |
Which of the following is false for Merits of the TDDS. |
A. | Avoidance of the First pass effect |
B. | A stable and controlled blood level |
C. | Termination at any time is conceivable |
D. | Skin irritation and allergic response |
Answer» D. Skin irritation and allergic response |
43. |
How many layer are seen in monolithic TDDS design? |
A. | 4 |
B. | 3 |
C. | 5 |
D. | 2 |
Answer» B. 3 |
44. |
How many layer are seen in membrane-controlled system? |
A. | 3 |
B. | 5 |
C. | 4 |
D. | 6 |
Answer» C. 4 |
45. |
A method of permeation enhancement that involves the use of charged chemical components across the skin membrane using an electric field. |
A. | Iontophoresis |
B. | Sonophoresis |
C. | Electrophoresis |
D. | Ion exchange |
Answer» A. Iontophoresis |
46. |
A physical method of permeation enhancement that involves the use of high frequency ultrasound. It is thought to influence the integrity of the SC and thus affect its penetrability. |
A. | Iontophoresis |
B. | Sonophoresis |
C. | Electrophoresis |
D. | Ion exchange |
Answer» B. Sonophoresis |
47. |
Which component are not included in combination of the SEDDS formulation? |
A. | Oil |
B. | Lipid |
C. | Drug |
D. | Wax |
Answer» D. Wax |
48. |
SEDDSs emulsify spontaneously to produce fine oil in water emulsions when introduced into an aqueous phase under gentle agitation and spread readily in the____________. |
A. | GIT |
B. | RT |
C. | UT |
D. | Liver |
Answer» A. GIT |
49. |
SEDDSs produce emulsion with droplet size between ____________. |
A. | 200 to 400nm |
B. | 100 to 300nm |
C. | 10 to 100nm |
D. | 1000nm |
Answer» B. 100 to 300nm |
50. |
Self micro emulsifying drug delivery systems (SMEDDSs) form transparent micro emulsions with droplet size of less than__________. |
A. | 50 nm |
B. | 70 nm |
C. | 100 nm |
D. | 200 nm |
Answer» A. 50 nm |
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