McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
Chapters
| 1. |
Aspirin is introduced by_________in 1889 |
| A. | Dreser's |
| B. | Emil Fischer and Mering |
| C. | Barger and Dale |
| D. | None of above |
| Answer» A. Dreser's | |
| 2. |
First hormone epinephrine was synthesized in Year |
| A. | 1903 |
| B. | 1904 |
| C. | 1909 |
| D. | 1889 |
| Answer» B. 1904 | |
| 3. |
Who is founder of modem medicine? |
| A. | Hippocartes |
| B. | Clark |
| C. | Charak |
| D. | Henry's |
| Answer» A. Hippocartes | |
| 4. |
Identification of a new chemical entity as a potential therapeutic agent (From Hit to Lead) is known as |
| A. | Drug discovery |
| B. | Drug development |
| C. | Both of above |
| D. | None of above |
| Answer» A. Drug discovery | |
| 5. |
The process of bringing a new pharmaceutical drug to the market once the lead compound has been identified through the process of drug discovery. (From Lead to NDA) is known as |
| A. | Drug discovery |
| B. | Drug development |
| C. | Both of above |
| D. | None of above |
| Answer» B. Drug development | |
| 6. |
Natural products or derivatives or synthetic substances with good binding ability in Drug discovery is known as |
| A. | Hit |
| B. | Lead |
| C. | NDA |
| D. | IND |
| Answer» A. Hit | |
| 7. |
Compound with good activity and selectivity in screening during drug discovery is known as |
| A. | Hit |
| B. | Lead |
| C. | NDA |
| D. | IND |
| Answer» B. Lead | |
| 8. |
The main goals of pre-clinical studies |
| A. | To determine the safe dose for first-in-man study |
| B. | To assess a product's safety profile |
| C. | A and B both |
| D. | None |
| Answer» C. A and B both | |
| 9. |
IND stands for |
| A. | Improved new drug |
| B. | Investigational new drug |
| C. | International new drug |
| D. | International novel drug |
| Answer» B. Investigational new drug | |
| 10. |
Human micro dosing studies conducted in which clinical phase ? |
| A. | Phase 0 |
| B. | Phase I |
| C. | Phase II |
| D. | Phase III |
| Answer» A. Phase 0 | |
| 11. |
MTD is |
| A. | Maximum targeted dose |
| B. | Minimum tolerated dose |
| C. | Minimum targeted dose |
| D. | Maximum tolerated dose |
| Answer» D. Maximum tolerated dose | |
| 12. |
Single ascending dose studies are done in_____ |
| A. | Phase lb |
| B. | Phase Ia |
| C. | Phase II |
| D. | Phase Ila |
| Answer» B. Phase Ia | |
| 13. |
NDA is |
| A. | New Drug Application |
| B. | New Drug approval |
| C. | Noval Drug Admistration |
| D. | New Drug agenda |
| Answer» A. New Drug Application | |
| 14. |
Phase IV trial is also known |
| A. | Base of clinical trial |
| B. | Multiple ascending dose era |
| C. | Post marketing Surveillance |
| D. | Pre-clinical trial |
| Answer» C. Post marketing Surveillance | |
| 15. |
How many people will be selected for phase I trial? |
| A. | The whole market will be under surveillance |
| B. | 300-3000 people |
| C. | 20-300 people |
| D. | 20-50 people |
| Answer» D. 20-50 people | |
| 16. |
How many people will be selected for phase II trial? |
| A. | The whole market will be under surveillance |
| B. | 300-3000 people |
| C. | 20-300 people |
| D. | 20-50 people |
| Answer» C. 20-300 people | |
| 17. |
How many people will be selected for phase III trial? |
| A. | The whole market will be under surveillance |
| B. | 300-3000 people |
| C. | 20-300 people |
| D. | 20-50 people |
| Answer» B. 300-3000 people | |
| 18. |
Which one of the following will be checked under phase IV surveillance? |
| A. | The whole market will be under surveillance |
| B. | 300-3000 people |
| C. | 20-300 people |
| D. | 20-50 people |
| Answer» A. The whole market will be under surveillance | |
| 19. |
Precision Medicine is an emerging approach depending on |
| A. | Genomic study of individual |
| B. | Diagnostic process of individual |
| C. | Diseases conditions |
| D. | None of above |
| Answer» A. Genomic study of individual | |
| 20. |
How many main families of GPCRs are there? |
| A. | 5 |
| B. | 6 |
| C. | 7 |
| D. | 4 |
| Answer» B. 6 | |
| 21. |
Which of the following reactions is catalyzed by the enzyme adenylate cyclase? |
| A. | Conversion of ATP to cyclic AMP |
| B. | Conversion of cyclic AMP to AMP |
| C. | Conversion of cyclic AMP to ATP |
| D. | Conversion of AMP to cyclic AMP |
| Answer» A. Conversion of ATP to cyclic AMP | |
| 22. |
Oxadiazole ring contains |
| A. | 1 Nitrogen /Oxygen |
| B. | 2 Oxygen/ Nitrogen |
| C. | 2 Nitrogen/Sulphur |
| D. | 2 Nitrogen/Oxygen |
| Answer» D. 2 Nitrogen/Oxygen | |
| 23. |
The hetroaromatic redical is called |
| A. | Anthryl |
| B. | Naphthyl |
| C. | Phenanthryl |
| D. | Dibenzyl |
| Answer» B. Naphthyl | |
| 24. |
Name of this aromatic ring is |
| A. | Diphenylmethyl ethane |
| B. | 2-ethyl-1-methyl naphthalene |
| C. | 1-ethyl-2-methyl naphthalene |
| D. | 1-ethyl-1-methyl naphthalene |
| Answer» C. 1-ethyl-2-methyl naphthalene | |
| 25. |
Name of this aromatic ring is |
| A. | Azopane |
| B. | Azepine |
| C. | Azepane |
| D. | None of above |
| Answer» C. Azepane | |
| 26. |
Which of the following statements best describes pharmacodynamics? |
| A. | The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by absorption, distribution, metabolism and excretion. |
| B. | The study of how drugs can be designed using molecular modelling based on a drug's pharmacophore. |
| C. | The study of how a drug interacts with its target binding site at the molecular level. |
| D. | The study of which functional groups are important in binding a drug to its target binding site and the identification of a pharmacophore. |
| Answer» C. The study of how a drug interacts with its target binding site at the molecular level. | |
| 27. |
Which of the following statements best describes pharmacokinetics? |
| A. | The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by various factors. |
| B. | The study of how drugs can be designed using molecular modelling based on a drug's pharmacophore. |
| C. | The study of how a drug interacts with its target binding site at the molecular level. |
| D. | The study of which functional groups are important in binding a drug to its target binding site and the identification of a pharmacophore. |
| Answer» A. The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by various factors. | |
| 28. |
What are soft drugs? |
| A. | Drugs given to babies |
| B. | Chemical drugs which are already found in the body |
| C. | Nutrients which kill the gut harmful microbes |
| D. | Anything that is not nutrients and enters the body through different routes |
| Answer» B. Chemical drugs which are already found in the body | |
| 29. |
The most important physicochemical properties affecting drug action
|
| A. | All of the above |
| B. | A and B both |
| C. | D and E both |
| D. | C and F both |
| Answer» A. All of the above | |
| 30. |
In QSAR, study of medicinal chemistry Q stands for |
| A. | Qualitative |
| B. | Quantitative |
| C. | Both |
| D. | Quantam |
| Answer» B. Quantitative | |
| 31. |
Dimercaprol is a chelating agent used in the treatment of |
| A. | Arsenic poisoning |
| B. | Lead poisoning |
| C. | Iron poisoning |
| D. | Vanadium poisoning |
| Answer» A. Arsenic poisoning | |
| 32. |
The non-polar compound dispersed |
| A. | By forming hydrogen bonding |
| B. | By interacting with lipid |
| C. | By forming drug receptor complex |
| D. | by forming hydrophilic bond |
| Answer» B. By interacting with lipid | |
| 33. |
pka is a parameter which indicates the |
| A. | Strength of drug as acid base reaction in water |
| B. | Aqueous phase in phosphate buffer |
| C. | Hydrophilic and lyphophilic character |
| D. | All of the above |
| Answer» D. All of the above | |
| 34. |
85% of drugs are ionizied in which pH- |
| A. | 2-5 |
| B. | 7-12 |
| C. | 1.5-8 |
| D. | Neutral |
| Answer» C. 1.5-8 | |
| 35. |
Bioisoterism is the process of |
| A. | Replacement similar group |
| B. | Replacement similar valence group |
| C. | Replacement similar mass no. group |
| D. | Addition of group having different mass no. |
| Answer» B. Replacement similar valence group | |
| 36. |
A drug like phenytoin & barbiturate when pka is larger than 7 is |
| A. | Ionised at all pH |
| B. | unionised at pH |
| C. | Ionised at pH 8 |
| D. | Unionised at pH 6 |
| Answer» D. Unionised at pH 6 | |
| 37. |
A drug where pka is 7 & unionised at all pH it is |
| A. | Weak acidic |
| B. | Very weak acidic |
| C. | Weak basic |
| D. | Very weak basic |
| Answer» B. Very weak acidic | |
| 38. |
Dissolution & pka helps in drug |
| A. | ionization & solubility |
| B. | dissociation & transportation |
| C. | Dissociation & solubility |
| D. | None of these |
| Answer» C. Dissociation & solubility | |
| 39. |
Bioisosteres are similar in their |
| A. | Physical character |
| B. | Chemical character |
| C. | Both character a & b |
| D. | Biochemical character |
| Answer» C. Both character a & b | |
| 40. |
Which of the following is not a bivalent? |
| A. | CO |
| B. | CS |
| C. | CC |
| D. | SH |
| Answer» D. SH | |
| 41. |
A molecule having 3 chiral centre carbon it has |
| A. | 4 set of diasters |
| B. | 9 set of enantiomers |
| C. | 6 set of monomers |
| D. | 9 set of diasters |
| Answer» B. 9 set of enantiomers | |
| 42. |
The 3D structure elucidation is done by process |
| A. | IR |
| B. | FTIR |
| C. | NMR |
| D. | MS |
| Answer» C. NMR | |
| 43. |
Which of the following is odd one regarding drug-receptor interaction |
| A. | Hydrogen bonding |
| B. | Electrostatic |
| C. | Weak Wander wall Force |
| D. | Dipole- induced dipole interaction |
| Answer» D. Dipole- induced dipole interaction | |
| 44. |
Which of the following is a fastest receptor |
| A. | Enzyme linked |
| B. | Ion- gated |
| C. | GPCR |
| D. | Nuclear |
| Answer» C. GPCR | |
| 45. |
Which of the following is not an optically isomer |
| A. | Enantiomers |
| B. | Epimers |
| C. | Disasters |
| D. | Meso |
| Answer» A. Enantiomers | |
| 46. |
Enantiomer has a higher affinity to receptor are called |
| A. | Eudismic |
| B. | Diastomer |
| C. | Eutomer |
| D. | None of these |
| Answer» A. Eudismic | |
| 47. |
Which type of hydrogen bonding present when hydrogen bonding occurs between molecules? |
| A. | Intramolecular |
| B. | Intermolecular |
| C. | A & B both |
| D. | None of them |
| Answer» B. Intermolecular | |
| 48. |
Which compound is capable of forming a ring structure with metal atoms? |
| A. | Ligands |
| B. | Chelates |
| C. | Surfactants |
| D. | All of the above |
| Answer» B. Chelates | |
| 49. |
For dissolution of solute in solvent which condition is necessary?
|
| A. | 1 & 2 |
| B. | 2 & 3 |
| C. | 1 & 3 |
| D. | 1, 2 & 3 |
| Answer» B. 2 & 3 | |
| 50. |
Addition of polar group in a drug increases its interaction with |
| A. | Water |
| B. | Lipid |
| C. | Both |
| D. | None |
| Answer» A. Water | |
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