What reasons make tissue-drug binding important for drug distribution?

Related MCQs

• Factors altering the binding of the drug to the blood increases the volume of distribution of the drug and the factors that influence drug binding to the extravascular component decreases the volume of distribution.
• Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?
• Which of the following factors for protein drug binding is a drug interaction factor?
• The extent of drug-protein binding can change with both changes in protein and drug concentration.
• Primary binding site for albumin is ………………binding site.
• Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.
• For a certain drug, the bile flow rate is 0.7 ml/mm, the biliary drug concentration is 2g/ml and the plasma drug concentration is 0.8g/ml. What will be the bile clearance?
• If drug have very small volume of distribution it is likely that the drug
• ……………composed of groups of tissues with lower blood perfusion and different affinity the drug with slow drug distribution.
• To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient?