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Q. |
A 64-year-old man has terminal cancer with hepatic metastases. He is treated with oral morphine (Oramorph) solution for pain relief.Which is the most important pharmacodynamic factor in determining the appropriate timing between doses? |
A. | bioavailability |
B. | first pass metabolism |
C. | gastric emptying |
D. | plasma half-life |
E. | renal clearance |
Answer» B. first pass metabolism |
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