McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Biology .
Chapters
| 1. |
Diuretics |
| A. | Work to lower BP initially by decreasing peripheral vascular resistance |
| B. | Thiazide diuretics are potassium sparing |
| C. | Are effective in lowering Bp by 20 – 25 mmHg in most patients |
| D. | BP response to thiazides continues to increase at doses greater than usual therapeutic dose. |
| E. | Diuretics may impair glucose tolerance |
| Answer» E. Diuretics may impair glucose tolerance | |
| 2. |
Methyl dopa |
| A. | Lowers the heart rate and cardiac output more than clonidine does |
| B. | Causes reduction in renal vascular resistance |
| C. | Has minimal CNS side effects |
| D. | Has 80% bioavailability |
| E. | Usual therapeutic dose is about 1 – 2 mg/day |
| Answer» B. Causes reduction in renal vascular resistance | |
| 3. |
Propranolol |
| A. | Is a B1 specific blocker |
| B. | Causes prominent postural hypotension |
| C. | Inhibits the stimulation of renin production by catecholamines |
| D. | Has a half life of 12 hours |
| E. | Has no effect on plasma lipids |
| Answer» C. Inhibits the stimulation of renin production by catecholamines | |
| 4. |
Hydralazine |
| A. | Dilates veins but not arterioles |
| B. | Is contraindicated in the treatment of preeclampsia |
| C. | Can cause an SLE type syndrome in up to 10 – 20% of patients |
| D. | Causes orthostatic hypotension in many cases |
| E. | Is extremely useful as a single agent in treatment of hypertension |
| Answer» C. Can cause an SLE type syndrome in up to 10 – 20% of patients | |
| 5. |
Which of the following drug’s metabolism characteristics are bimodally distributed in the population? |
| A. | Sodium nitroprusside |
| B. | Clonidine |
| C. | Minoxidil |
| D. | Hydralazine |
| E. | Phentolamine |
| Answer» D. Hydralazine | |
| 6. |
The ACE inhibitors |
| A. | Inhibit peptidyl dipeptidase thus preventing the inactivation of bradykinin |
| B. | Captopril is a prodrug |
| C. | Are to be used with caution in patients with IHD as reflex sympathetic activation occurs secondary to the hypotensive effects of the ACE inhibitors |
| D. | Have no role in treating the normotensive diabetic patients |
| E. | Are useful antihypertensive agents in late pregnancy |
| Answer» A. Inhibit peptidyl dipeptidase thus preventing the inactivation of bradykinin | |
| 7. |
The following drugs when combined with ACE inhibitors may produce troublesome problems EXCEPT |
| A. | Diclofenac |
| B. | Potassium supplements |
| C. | Spironolactone |
| D. | Lithium |
| E. | Theophylline |
| Answer» E. Theophylline | |
| 8. |
The nitrates |
| A. | Have an antianginal effect via vasodilation of arterioles only |
| B. | Serve to increase preload |
| C. | Have a direct effect on cardiac muscle to cause a decrease in anginal symptoms |
| D. | All have high oral bioavailability |
| E. | Are contraindicated in the presence of increased intracranial pressure |
| Answer» E. Are contraindicated in the presence of increased intracranial pressure | |
| 9. |
Regarding Calcium channel blockers |
| A. | Calcium channel blockers are not bound to plasma proteins |
| B. | Nifedipine has less vascular potency than verapamil |
| C. | Felodipine has been shown to inhibit insulin release in humans |
| D. | Diltiazem has a plasma half life of 3 – 4 hours |
| E. | Verapamil has high affinity for cerebral blood vessels thus decreasing vasospasm post subarachnoid haemorrhage |
| Answer» D. Diltiazem has a plasma half life of 3 – 4 hours | |
| 10. |
Which of the following calcium channel blockers is excreted predominantly in the faeces? |
| A. | Nifedipine |
| B. | Felodipine |
| C. | Diltiazem |
| D. | Nimodipine |
| E. | Verapamil |
| Answer» C. Diltiazem | |
| 11. |
Which of the following calcium channel blockers has the longest plasma half life? |
| A. | Felodipine |
| B. | Diltiazem |
| C. | Amlodipine |
| D. | Nimodipine |
| E. | Verapamil |
| Answer» C. Amlodipine | |
| 12. |
The following include major actions of digoxin on cardiac electrical functions EXCEPT |
| A. | Decreased PR interval on ECG |
| B. | Decreased conduction velocity at the AV node |
| C. | Increased automaticity of the atrial muscle |
| D. | Decreased effective refractory period in purkinje system/ventricles |
| E. | Bigeminy can be induced by digoxin |
| Answer» A. Decreased PR interval on ECG | |
| 13. |
Which of the following increases the risk of digoxin induced arrhythmias? |
| A. | Hyperkalaemia |
| B. | Hypercalcaemia |
| C. | Hypermagnesaemia |
| D. | Hyperuricaemia |
| E. | Hypernatraemia |
| Answer» B. Hypercalcaemia | |
| 14. |
Digoxin |
| A. | Is poorly lipid soluble |
| B. | Is extensively metabolized |
| C. | Has a half life in the body of 40 hours |
| D. | Has minimal GI toxicity |
| E. | Is 80% bound to plasma proteins |
| Answer» C. Has a half life in the body of 40 hours | |
| 15. |
Drugs which may increase digoxin effect include all of the following EXCEPT |
| A. | Amiodarone |
| B. | Diltiazem |
| C. | Frusemide |
| D. | Quinidine |
| E. | Antacids |
| Answer» E. Antacids | |
| 16. |
Which of the following drugs has the smallest volume of distribution? |
| A. | Chloroquine |
| B. | Verapamil |
| C. | Imipramine |
| D. | Warfarin |
| E. | Digoxin |
| Answer» D. Warfarin | |
Done Studing? Take A Test.
Great job completing your study session! Now it's time to put your knowledge to the test. Challenge yourself, see how much you've learned, and identify areas for improvement. Don’t worry, this is all part of the journey to mastery. Ready for the next step? Take a quiz to solidify what you've just studied.