McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
Chapters
| 1. |
The accelerated stability studies are primarily used to determine: |
| A. | energy of the activation of the reaction |
| B. | k value at elevated temperatures |
| C. | k value at the room temperature |
| D. | shelf life of the product |
| Answer» D. shelf life of the product | |
| 2. |
The specific rate constant (k) determined for aspirin hydrolysis in pH 1.0 buffer at 1 mg/ml concentration is 2.0x10-3 min-1 at 25°C. The shelf life of the product is (in minutes): |
| A. | 2.0 |
| B. | 52 |
| C. | 104 |
| D. | 346 |
| Answer» B. 52 | |
| 3. |
In general, reaction rate constants in neutral pH are comparatively: |
| A. | equal |
| B. | higher |
| C. | lower |
| D. | zero |
| Answer» C. lower | |
| 4. |
The expiry date for a tablet is not mentioned on the label. It means that the expiry time in years is: |
| A. | five years |
| B. | nil |
| C. | three years |
| D. | two years |
| Answer» A. five years | |
| 5. |
Penicillin G is prepared as a salt of procaine penicillin G. Now the rate of decomposition of penicillin G will be: |
| A. | increased |
| B. | reduced |
| C. | unchanged |
| D. | unpredictable |
| Answer» B. reduced | |
| 6. |
According to International Pharmaceutical Federation, the recommended overages be limited to the maximum percent of: |
| A. | five |
| B. | ten |
| C. | thirty |
| D. | twenty |
| Answer» C. thirty | |
| 7. |
Usually, the rate of a chemical reaction may be enhanced by: |
| A. | cooling the reaction mixture |
| B. | increasing the rate of stirring |
| C. | raising the temperature of the reaction mixture |
| D. | using stoichiometric quantities of each reactant |
| Answer» C. raising the temperature of the reaction mixture | |
| 8. |
Which of the following expression is correct for the determination of shelf life for a first order decomposition? |
| A. | t1/2 = 0.105/k |
| B. | t90 = 0.693/k |
| C. | t1/2 = 0.693/k |
| D. | t90 = 0.105/k |
| Answer» D. t90 = 0.105/k | |
| 9. |
Regarding the influence of the solvent on the rate of reaction, solvents having the internal pressure: |
| A. | HIGHER produce products with HIGHER internal pressure |
| B. | HIGHER favour the formation of products having LOWER internal pressure |
| C. | LOWER yield products having HIGHER internal pressure |
| D. | LOWER retard the formation of products with LOWER internal pressure |
| Answer» A. HIGHER produce products with HIGHER internal pressure | |
| 10. |
During autoclaving of dextrose solution, a straw colour is observed. It is due to the presence of a substance called: |
| A. | furfural |
| B. | 5-hydroxymethylfurfural |
| C. | 5-hydroxyfurfural |
| D. | 5-methylfurfural |
| Answer» B. 5-hydroxymethylfurfural | |
| 11. |
In injections, procaine undergoes the degradation reactions in the following sequence: |
| A. | decarboxylation and hydrolysis |
| B. | hydrolysis and decarboxylation |
| C. | hydrolysis, decarboxylation and oxidation |
| D. | oxidation, decarboxylation and hydrolysis |
| Answer» B. hydrolysis and decarboxylation | |
| 12. |
On a product, the label states ‘protect from light’. What type of decomposition does the product undergo? |
| A. | carboxylation |
| B. | decarboxylation |
| C. | hydrolysis |
| D. | oxidation |
| Answer» D. oxidation | |
| 13. |
Which of the following reactions is observed in the degradation of ampicillin? |
| A. | decarboxylation |
| B. | hydrolysis |
| C. | oxidation |
| D. | recimization |
| Answer» B. hydrolysis | |
| 14. |
Aspirin undergoes decomposition in a formulation. It can be prevented by: |
| A. | adding a chelating agent |
| B. | adding an antioxidant |
| C. | protecting it from light |
| D. | suppressing its solubility |
| Answer» D. suppressing its solubility | |
| 15. |
Which one of the following is primarily NOT a chemical decomposition? |
| A. | isomerisation |
| B. | hydrolysis |
| C. | oxidation |
| D. | volatilization |
| Answer» D. volatilization | |
| 16. |
For the validity of accelerated stability studies of solution dosage form, the energy of activation should be in the range of (in units of kcal/mole). |
| A. | 0 to 10 |
| B. | 11 to 30 |
| C. | 31 to 50 |
| D. | 51 to 70 |
| Answer» B. 11 to 30 | |
| 17. |
Which one of these methods is the MOST effective in preventing the rate of hydrolysis? |
| A. | buffer |
| B. | complexation |
| C. | removal of water |
| D. | suppression of solubility |
| Answer» C. removal of water | |
| 18. |
During storage, crystal growth is observed in a suspension due to: |
| A. | absorption of water |
| B. | fluctuations in the ambient temperatures |
| C. | presence of suspending agent |
| D. | volatilization of solids |
| Answer» B. fluctuations in the ambient temperatures | |
| 19. |
The storage directions on a parenteral solution specify ‘store in a cool place’. This may be stored in: |
| A. | an air-conditioned area at 10°C |
| B. | a refrigerator at 15°C |
| C. | a place whose temperature is set at 5°C |
| D. | room temperature, at 25°C |
| Answer» B. a refrigerator at 15°C | |
| 20. |
which of the following is cause of physical degradation of drug? |
| A. | volatilisation of components during storage |
| B. | Changes from one state to another |
| C. | Change in colour |
| D. | All of the above |
| Answer» D. All of the above | |
| 21. |
Which of the following factors affect the rate of reaction? |
| A. | Temperature |
| B. | Catalysis |
| C. | Dielectric constant |
| D. | All of the above |
| Answer» D. All of the above | |
| 22. |
The effect of temperature on rate of reaction is explained by |
| A. | Arrhenius equation |
| B. | Nernst equation |
| C. | Noyes Whitney equation |
| D. | Fick's first law |
| Answer» A. Arrhenius equation | |
| 23. |
The unit of activation energy is |
| A. | kJ/mol |
| B. | J |
| C. | N/m |
| D. | mm |
| Answer» A. kJ/mol | |
| 24. |
The dielectric constant is used to measure |
| A. | Viscosity of solvent |
| B. | polarity of the solvent |
| C. | temperature of solvent |
| D. | flowability of solvent |
| Answer» B. polarity of the solvent | |
| 25. |
Accelerated stability testing is done to |
| A. | predict shelf of the formulation |
| B. | Predict dissociation constant |
| C. | Predict diffusion constant |
| D. | Determine activation energy |
| Answer» A. predict shelf of the formulation | |
| 26. |
ICH stands for |
| A. | Indian council on harmonisation |
| B. | International Conference On Harmonisation |
| C. | Inter Cranial Healer |
| D. | None of the above |
| Answer» B. International Conference On Harmonisation | |
| 27. |
Stability Data for Climatic zone III & IV comes under___________ICH guideline |
| A. | Q1C |
| B. | Q1E |
| C. | Q1F |
| D. | Q1D |
| Answer» C. Q1F | |
| 28. |
Climatic zone II is |
| A. | Moderate climate |
| B. | Subtropical and Mediterranean climate |
| C. | Hot/dry climate |
| D. | Hot/humid climate |
| Answer» B. Subtropical and Mediterranean climate | |
| 29. |
Stability testing is done |
| A. | to determine shelf life of product |
| B. | to determine the components used for packaging |
| C. | to get information at preformulation stage |
| D. | All of the above |
| Answer» D. All of the above | |
| 30. |
........... is the time necessary for the concentration of the reactant to decrease to 90% of its original concentration. |
| A. | Product life |
| B. | Shelf life |
| C. | Half life |
| D. | None of the above |
| Answer» B. Shelf life | |
| 31. |
Generally, Stability testing is employed for........... |
| A. | Delivering evidences of the change in quality of the drug product with time. |
| B. | Confirming shelf life for the drug product. |
| C. | Determining container closure system suitability. |
| D. | All of the above |
| Answer» D. All of the above | |
| 32. |
A zero-order reaction is a reaction having rate of concentration of reactant. |
| A. | Dependent |
| B. | Partially dependent |
| C. | Independent |
| D. | None of the above |
| Answer» C. Independent | |
| 33. |
In a second-order reaction, the sum of the exponents in the rate law is equal to............... |
| A. | Zero |
| B. | One |
| C. | Two |
| D. | Three |
| Answer» C. Two | |
| 34. |
..........technique is utilized only during determination of order of reaction, when the rate law involved by only single concentration term. |
| A. | The concentration |
| B. | The half of the concentration |
| C. | The square of the concentration |
| D. | None of the above |
| Answer» C. The square of the concentration | |
| 35. |
...........technique is utilized only when the rate law involved by only single concentration term for determination of order of reaction. |
| A. | Half Life Method |
| B. | Graphical Method |
| C. | Initial Rate Method |
| D. | Van't Hoff Differential Method |
| Answer» A. Half Life Method | |
| 36. |
......... technique is utilized in presence single reactant for determination of order of reaction. |
| A. | Half Life Method |
| B. | Graphical Method |
| C. | Initial Rate Method |
| D. | Van't Hoff Differential Method |
| Answer» B. Graphical Method | |
| 37. |
In exothermic Reaction, if we increase the temperature in the exothermic reaction the rate of reaction will......... |
| A. | Increases |
| B. | Decrease |
| C. | Remains constant |
| D. | None of the above |
| Answer» B. Decrease | |
| 38. |
If ions of similar charges involve in reaction it will............rate of reaction. |
| A. | Increases |
| B. | Decreases |
| C. | Remains constant |
| D. | None of the above |
| Answer» B. Decreases | |
| 39. |
The drug molecule is degradate by exposure of light it affects substantial degradation of drug molecule this phenomenon is known as........... |
| A. | Photolytic degradation |
| B. | Chemical degradation |
| C. | Physical degradation |
| D. | None of the above |
| Answer» A. Photolytic degradation | |
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