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Q. |
A 30-year-old woman has a right mastectomy and axillary lymph node dissection for a carcinoma diagnosed by fine needle aspiration cytology. The histologic pattern is that of a poorly differentiated carcinoma that is negative for oestrogen and progesterone receptors, but is positive for HER2/neu. One axillary lymph node demonstrates micro- metastases. Her 32 year old sister is found to have a similar lesion. Which of the following statements regarding risk factors for this lesion is the most appropriate? |
A. | A history of late menarche is likely to be present in females in this family |
B. | Fibrocystic changes were present for many years |
C. | She had a history of exposure to hydrocarbon compounds |
D. | She has a positive antinuclear antibody test |
E. | These findings suggest a BRCA-1 mutation |
Answer» E. These findings suggest a BRCA-1 mutation |
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