McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
Chapters
| 1. |
The most important physicochemical properties affecting drug action
|
| A. | All of the above |
| B. | A and B both |
| C. | D and E both |
| D. | C and F both |
| Answer» A. All of the above | |
| 2. |
In QSAR, study of medicinal chemistry Q stands for |
| A. | Qualitative |
| B. | Quantitative |
| C. | Both |
| D. | Quantam |
| Answer» B. Quantitative | |
| 3. |
Dimercaprol is a chelating agent used in the treatment of |
| A. | Arsenic poisoning |
| B. | Lead poisoning |
| C. | Iron poisoning |
| D. | Vanadium poisoning |
| Answer» A. Arsenic poisoning | |
| 4. |
The non-polar compound dispersed |
| A. | By forming hydrogen bonding |
| B. | By interacting with lipid |
| C. | By forming drug receptor complex |
| D. | by forming hydrophilic bond |
| Answer» B. By interacting with lipid | |
| 5. |
pka is a parameter which indicates the |
| A. | Strength of drug as acid base reaction in water |
| B. | Aqueous phase in phosphate buffer |
| C. | Hydrophilic and lyphophilic character |
| D. | All of the above |
| Answer» D. All of the above | |
| 6. |
85% of drugs are ionizied in which pH- |
| A. | 2-5 |
| B. | 7-12 |
| C. | 1.5-8 |
| D. | Neutral |
| Answer» C. 1.5-8 | |
| 7. |
Bioisoterism is the process of |
| A. | Replacement similar group |
| B. | Replacement similar valence group |
| C. | Replacement similar mass no. group |
| D. | Addition of group having different mass no. |
| Answer» B. Replacement similar valence group | |
| 8. |
A drug like phenytoin & barbiturate when pka is larger than 7 is |
| A. | Ionised at all pH |
| B. | unionised at pH |
| C. | Ionised at pH 8 |
| D. | Unionised at pH 6 |
| Answer» D. Unionised at pH 6 | |
| 9. |
A drug where pka is 7 & unionised at all pH it is |
| A. | Weak acidic |
| B. | Very weak acidic |
| C. | Weak basic |
| D. | Very weak basic |
| Answer» B. Very weak acidic | |
| 10. |
Dissolution & pka helps in drug |
| A. | ionization & solubility |
| B. | dissociation & transportation |
| C. | Dissociation & solubility |
| D. | None of these |
| Answer» C. Dissociation & solubility | |
| 11. |
Bioisosteres are similar in their |
| A. | Physical character |
| B. | Chemical character |
| C. | Both character a & b |
| D. | Biochemical character |
| Answer» C. Both character a & b | |
| 12. |
Which of the following is not a bivalent? |
| A. | CO |
| B. | CS |
| C. | CC |
| D. | SH |
| Answer» D. SH | |
| 13. |
A molecule having 3 chiral centre carbon it has |
| A. | 4 set of diasters |
| B. | 9 set of enantiomers |
| C. | 6 set of monomers |
| D. | 9 set of diasters |
| Answer» B. 9 set of enantiomers | |
| 14. |
The 3D structure elucidation is done by process |
| A. | IR |
| B. | FTIR |
| C. | NMR |
| D. | MS |
| Answer» C. NMR | |
| 15. |
Which of the following is odd one regarding drug-receptor interaction |
| A. | Hydrogen bonding |
| B. | Electrostatic |
| C. | Weak Wander wall Force |
| D. | Dipole- induced dipole interaction |
| Answer» D. Dipole- induced dipole interaction | |
| 16. |
Which of the following is a fastest receptor |
| A. | Enzyme linked |
| B. | Ion- gated |
| C. | GPCR |
| D. | Nuclear |
| Answer» C. GPCR | |
| 17. |
Which of the following is not an optically isomer |
| A. | Enantiomers |
| B. | Epimers |
| C. | Disasters |
| D. | Meso |
| Answer» A. Enantiomers | |
| 18. |
Enantiomer has a higher affinity to receptor are called |
| A. | Eudismic |
| B. | Diastomer |
| C. | Eutomer |
| D. | None of these |
| Answer» A. Eudismic | |
| 19. |
Which type of hydrogen bonding present when hydrogen bonding occurs between molecules? |
| A. | Intramolecular |
| B. | Intermolecular |
| C. | A & B both |
| D. | None of them |
| Answer» B. Intermolecular | |
| 20. |
Which compound is capable of forming a ring structure with metal atoms? |
| A. | Ligands |
| B. | Chelates |
| C. | Surfactants |
| D. | All of the above |
| Answer» B. Chelates | |
| 21. |
For dissolution of solute in solvent which condition is necessary?
|
| A. | 1 & 2 |
| B. | 2 & 3 |
| C. | 1 & 3 |
| D. | 1, 2 & 3 |
| Answer» B. 2 & 3 | |
| 22. |
Addition of polar group in a drug increases its interaction with |
| A. | Water |
| B. | Lipid |
| C. | Both |
| D. | None |
| Answer» A. Water | |
| 23. |
Methyl Prednisolone is water insoluble but its which salt is water soluble? |
| A. | Sodium |
| B. | Hydrochloride |
| C. | Salicylate |
| D. | Palmitate |
| Answer» A. Sodium | |
| 24. |
Phenobarbitone is water insoluble but its which salt is water soluble? |
| A. | Sodium |
| B. | Hydrochloride |
| C. | Salicylate |
| D. | Palmitate |
| Answer» A. Sodium | |
| 25. |
Which ester of Chloramphenicol is prepared to mask its bitter taste? |
| A. | Sodium |
| B. | Hydrochloride |
| C. | Salicylate |
| D. | Palmitate |
| Answer» D. Palmitate | |
| 26. |
Generally drugs are absorbed in which form? |
| A. | In ionized form |
| B. | In unionized form |
| C. | In both of abone form |
| D. | In none of above form |
| Answer» B. In unionized form | |
| 27. |
Most weakly acidic drugs (pKa < 2) are absorbed from |
| A. | Stomach |
| B. | Intestine |
| C. | Stomach and Intestine |
| D. | They Can’t be absorbed |
| Answer» A. Stomach | |
| 28. |
Most weakly basic drugs (pKa > 8) are absorbed from |
| A. | Stomach |
| B. | Intestine |
| C. | Stomach and Intestine |
| D. | They Can’t be absorbed |
| Answer» B. Intestine | |
| 29. |
Absorption of neutral drugs (pKa 6- 8) is independent of pH. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 30. |
Which form of barbituric acid has CNS activity? |
| A. | 1 |
| B. | 2 |
| C. | 3 |
| D. | All |
| Answer» C. 3 | |
| 31. |
Addition of non-polar group _________ partition co-efficient |
| A. | Improves |
| B. | Reduces |
| C. | No effect on |
| D. | none |
| Answer» A. Improves | |
| 32. |
Gentamicin, streptokinase can be given |
| A. | Orally |
| B. | Parentrally |
| C. | Both of above |
| D. | None of above |
| Answer» B. Parentrally | |
| 33. |
Distance between H-bond is |
| A. | 2.3- 5.2 A° |
| B. | 1.2 – 2.5 A° |
| C. | 2.5 – 3.2 A° |
| D. | 3.2 – 8.5 A° |
| Answer» C. 2.5 – 3.2 A° | |
| 34. |
Angel of H-bond |
| A. | 1.3 – 1.8° |
| B. | 13-18° |
| C. | 130 – 180 ° |
| D. | 1300 – 1800 ° |
| Answer» C. 130 – 180 ° | |
| 35. |
Strength of H-bond is |
| A. | 1-7 Kcal/mol |
| B. | 10-70 Kcal/mol |
| C. | 10-17 Kcal/mol |
| D. | 17-70 Kcal/mol |
| Answer» A. 1-7 Kcal/mol | |
| 36. |
p-nitrophenol contains |
| A. | Intramolecular H-bond |
| B. | Intermolecular H-bond |
| C. | Both of above |
| D. | None of above |
| Answer» B. Intermolecular H-bond | |
| 37. |
Which one of the following factors related to protein-drug binding is not related to drugs? |
| A. | Physicochemical characteristics of a drug |
| B. | The concentration of the drug in the body |
| C. | The affinity of the drug for binding |
| D. | Number of binding sites on the binding agent |
| Answer» D. Number of binding sites on the binding agent | |
| 38. |
Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site? |
| A. | Competition between the drug and the binding site |
| B. | Competition between drugs and normal body constituents |
| C. | Allosteric changes in a protein molecule |
| D. | Inter subject variation |
| Answer» D. Inter subject variation | |
| 39. |
Which of the following factors for protein drug binding is a drug interaction factor? |
| A. | Competition between drugs for the binding site |
| B. | Age |
| C. | Physicochemical characteristics of a drug |
| D. | Physicochemical characteristics of the protein or binding agent |
| Answer» A. Competition between drugs for the binding site | |
| 40. |
Only unbound or free drug is capable of being eliminated. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 41. |
Plasma proteins bound with drugs by formation of |
| A. | Hydrogen bonding |
| B. | Hydrophobc bonding |
| C. | Vander-waals force |
| D. | All |
| Answer» D. All | |
| 42. |
The most significant protein involved in binding with a drug is |
| A. | Albumin |
| B. | Glycoprotein |
| C. | Lipoprotein |
| D. | Globulin |
| Answer» A. Albumin | |
| 43. |
The most abundant plasma protein is |
| A. | Albumin (HAS – Human serum albumin) |
| B. | Glycoprotein |
| C. | Lipoprotein |
| D. | Globulin |
| Answer» A. Albumin (HAS – Human serum albumin) | |
| 44. |
Chelating agent Dimercaprol is used in the treatment of |
| A. | Lead poisoning |
| B. | Vanadium poisoning |
| C. | Arsenic poisoning |
| D. | All of above |
| Answer» C. Arsenic poisoning | |
| 45. |
In Lead and vanadium poisoning, which chelating agent is used as an antidote? |
| A. | Disodium EDTA |
| B. | Haemoglobin |
| C. | Cyanocobalamine |
| D. | Dimercaprol |
| Answer» A. Disodium EDTA | |
| 46. |
Absorption of Tetracycline is reduced in the presence of milk because of |
| A. | Hydrogen bonding |
| B. | Protein binding |
| C. | Ionization |
| D. | Chelation |
| Answer» D. Chelation | |
| 47. |
Functional groups of same valance and ring equivalents are known as |
| A. | Classical Bioisosteres |
| B. | Non- Classical Bioisosteres |
| C. | Enantiomer |
| D. | Geometric isomer |
| Answer» A. Classical Bioisosteres | |
| 48. |
Bioisosteres have |
| A. | Same physical properties |
| B. | Same chemical properties |
| C. | Similar biological properties |
| D. | All of above |
| Answer» D. All of above | |
| 49. |
R (-) Epinephrine shows 3 point of interaction with receptor while S (+)Epinephrine shows 2 point of interaction with receptor. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 50. |
(+) Warfarin is _____times more potent than (-) Warfarin. |
| A. | 2 |
| B. | 3 |
| C. | 4 |
| D. | 5 |
| Answer» D. 5 | |
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