McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
Chapters
| 1. |
Biotransformation of drugs is defined as the conversion from one physical form to another. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 2. |
The drug biotransformation is a detoxification process. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 3. |
Phase 1 reactions are also known as a synthetic reaction. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 4. |
The phase I reactions are detoxification pathways. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 5. |
The phase II reactions are detoxification pathways. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 6. |
Following are the Phase I reactions except ____________ |
| A. | Oxidative reactions |
| B. | Hydrolytic reactions |
| C. | Reductive reactions |
| D. | Sulphide reactions |
| Answer» D. Sulphide reactions | |
| 7. |
Which of the following statements is the closest description of Phase I metabolism? |
| A. | Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites |
| B. | Reactions which occur in the blood supply. |
| C. | Reactions which add a polar functional group to a drug. |
| D. | Reactions which occur in the gut wall. |
| Answer» C. Reactions which add a polar functional group to a drug. | |
| 8. |
Which of the following statements is the closest description of Phase II metabolism? |
| A. | Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites. |
| B. | Reactions which occur in the blood supply. |
| C. | Reactions which add a polar functional group to a drug. |
| D. | Reactions which occur in the gut wall. |
| Answer» A. Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites. | |
| 9. |
Which of the following is not a characteristic of the moieties that are transferred to the substrate in phase II reactions? |
| A. | Simple endogenous molecules are transferred |
| B. | Large molecular sized groups are attached |
| C. | Strong polar groups are attached |
| D. | Strong nonpolar groups are attached |
| Answer» D. Strong nonpolar groups are attached | |
| 10. |
Which of the following enzymes is not involved in catalyzing Phase I metabolic reaction? |
| A. | Flavin-containing monooxygenases |
| B. | Oxidation of alkyl groups |
| C. | Glucuronyl transferase |
| D. | Esterases |
| Answer» C. Glucuronyl transferase | |
| 11. |
Which of the following reactions is not a Phase I metabolic transformation? |
| A. | Reduction of ketones |
| B. | Conjugation to alcohols |
| C. | Monoamine oxidases |
| D. | Esterhydrolysis |
| Answer» B. Conjugation to alcohols | |
| 12. |
What is the major end product of oxidation of aromatic carbon atoms? |
| A. | Arenols |
| B. | Catechol |
| C. | Glutathione |
| D. | Arene oxide |
| Answer» A. Arenols | |
| 13. |
Which of the following is not a common N containing functional groups which undergo reduction reactions? |
| A. | Nitro compounds |
| B. | Azo compounds |
| C. | N-oxide compounds |
| D. | Nitrite compounds |
| Answer» D. Nitrite compounds | |
| 14. |
What does the hydrolysis of Aspirin yield us with? |
| A. | Salicylic acid only |
| B. | Salicylic acid and CH3COOH |
| C. | CH3COOH |
| D. | Succinic acid |
| Answer» B. Salicylic acid and CH3COOH | |
| 15. |
Which enzyme is important in the Phase II reactions? |
| A. | Esterase |
| B. | Amidases |
| C. | Transferase |
| D. | Aldo-keto-reductases |
| Answer» C. Transferase | |
| 16. |
Which of the following groups is least susceptible to cytochrome P450 enzymes? |
| A. | Terminal methyl groups |
| B. | Epoxide group |
| C. | Benzylic carbon atoms |
| D. | Quaternary carbon atoms |
| Answer» D. Quaternary carbon atoms | |
| 17. |
Alkenes and aromatic groups can be metabolised to diols. Which enzymes are involved? |
| A. | cytochrome P450 enzymes |
| B. | epoxide hydrolase |
| C. | both of the above |
| D. | neither of the above |
| Answer» C. both of the above | |
| 18. |
Solubility of a drug in polar solvents and Non-polar solvents depends upon |
| A. | Chemical structure |
| B. | Particle size |
| C. | Crystal form |
| D. | All of above |
| Answer» D. All of above | |
| 19. |
Higher will be the diffusion of the drug across the membrane if |
| A. | Higher value of partition-coefficient |
| B. | Low value of partition-coefficient |
| C. | Higher water soluble |
| D. | None of above |
| Answer» A. Higher value of partition-coefficient | |
| 20. |
Diazepam gets metabolised into Hydroxydiazepam is example of |
| A. | Oxidation at allylic carbon atom |
| B. | Oxidation at the carbon alpha to carbonyl and imino group |
| C. | Oxidation at benzylic carbon atom |
| D. | Aromatic and Side chain Hydroxylation |
| Answer» B. Oxidation at the carbon alpha to carbonyl and imino group | |
| 21. |
__________reaction is most common in drugs having ester or amide functional groups |
| A. | Oxidative reactions |
| B. | Reduction |
| C. | Hydrolysis |
| D. | Phase I |
| Answer» C. Hydrolysis | |
| 22. |
UDPGA means.... |
| A. | Urane diphospho -a- D glucuronic acid |
| B. | Uridine diphospho -a- D glucuronic acid |
| C. | Uridine diphospho-D glucuronic acid |
| D. | Uric diphospho -a- D glucuronic acid |
| Answer» B. Uridine diphospho -a- D glucuronic acid | |
| 23. |
Which of the following statement is false? |
| A. | D-glucuronic acid is easily available |
| B. | Several functional groups can be easily linked with the D-glucuronic acid |
| C. | Conjugation with D-glucuronic acid occurs to a high degree |
| D. | Whole animal kingdom have the common ability to produce D-glucuronic acid |
| Answer» D. Whole animal kingdom have the common ability to produce D-glucuronic acid | |
| 24. |
Which enzyme is of the utmost importance for the 2nd step in the formation of Glucuronide? |
| A. | Esterase |
| B. | Amidases |
| C. | Transferase |
| D. | UDP-glucuronyl tr |
| Answer» A. Esterase | |
| 25. |
What is the site of first-pass metabolism before molecules reach systemic circulation? |
| A. | Kidney |
| B. | Throat |
| C. | Liver |
| D. | Intestine |
| Answer» D. Intestine | |
| 26. |
What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme and P-glycoprotein? |
| A. | Kidney |
| B. | Throat |
| C. | Liver |
| D. | Intestine |
| Answer» C. Liver | |
| 27. |
What test uses microsomal extracts from the ER for in-vitro drug metabolism studies? |
| A. | Ames test |
| B. | Biochemical tests |
| C. | Serology |
| D. | Polymorphisms |
| Answer» A. Ames test | |
| 28. |
Which of the following are protein components of the cytochrome P450 system? |
| A. | Heme protein CYP450 |
| B. | NADH-CYP450 reductase |
| C. | NADPH-CYP450 reductase |
| D. | A and B E. A and C |
| Answer» A. Heme protein CYP450 | |
| 29. |
Which of the following statements is not true about cytochrome P450 enzymes? |
| A. | They contain haem and magnesium. |
| B. | They belong to a general class of enzymes called monooxygenases. |
| C. | There are over 30 different cytochrome P450 enzymes. |
| D. | Variation in cytochrome P450 enzyme profile between individuals can explain individual variation in drug susceptibility. |
| Answer» A. They contain haem and magnesium. | |
| 30. |
What is not a xenobiotic? |
| A. | Plant toxins |
| B. | Drugs |
| C. | Steroids |
| D. | Environmental pollutants |
| Answer» C. Steroids | |
| 31. |
What cytochrome P450 isozyme is most abundantly expressed in the human liver and intestines? |
| A. | CYP1A1 |
| B. | CYP3A4 |
| C. | CYP2C9 |
| D. | CYP2D6 |
| Answer» B. CYP3A4 | |
| 32. |
Which of the following is an antiarrhythmic drug that is a calcium channel blocker? |
| A. | Lidocaine |
| B. | Nitroglycerin |
| C. | Nifedipine |
| D. | Codeine |
| Answer» C. Nifedipine | |
| 33. |
What drug should not be given to a patient that is a poor CYP2D6 metabolizer? |
| A. | Codeine |
| B. | Lidocaine |
| C. | Nifedipine |
| D. | Nitroglycerin |
| Answer» A. Codeine | |
| 34. |
What injection is administered directly into systemic circulation causing rapid distribution? |
| A. | Intramuscular |
| B. | Intravenous |
| C. | Intracerebral |
| D. | Intraspinal |
| Answer» B. Intravenous | |
| 35. |
Where is Protonsil converted to Sulfanilamide? |
| A. | Liver |
| B. | Gut |
| C. | Kidney |
| D. | Colon |
| Answer» B. Gut | |
| 36. |
What are xenobiotics? |
| A. | Another form of antibiotics |
| B. | A form of nutrient |
| C. | Nutrients which kill the gut harmful microbes |
| D. | Anything that is not nutrients and enters the body through different routes |
| Answer» D. Anything that is not nutrients and enters the body through different routes | |
| 37. |
What is the active form of salicylic acid? |
| A. | Sialic acid |
| B. | Salic acid |
| C. | Salicylic acid |
| D. | Salicycle acid |
| Answer» C. Salicylic acid | |
| 38. |
What is the inactive form of Codeine? |
| A. | Codene |
| B. | Codane |
| C. | Morphine |
| D. | Poppy |
| Answer» C. Morphine | |
| 39. |
Which of the following is the correct decreasing order of drug metabolism? |
| A. | Liver > lungs > kidneys > intestine > placenta > skin > adrenals |
| B. | Liver > lungs > kidneys > intestine > adrenals > placenta > skin |
| C. | Liver > kidneys > lungs > intestine > placenta > adrenals > skin |
| D. | Liver > lungs > intestine > kidneys > placenta > adrenals > skin |
| Answer» A. Liver > lungs > kidneys > intestine > placenta > skin > adrenals | |
| 40. |
Which one of the following is reactive and a known carcinogenic? |
| A. | Cytochrome P-450 |
| B. | Catechol |
| C. | Glutathione |
| D. | Arene oxide |
| Answer» D. Arene oxide | |
| 41. |
Which of the following is not an example of a drug undergoing acetylation reaction? |
| A. | Hydrazine |
| B. | Salicylic acids |
| C. | Sulphonamides |
| D. | Histamines |
| Answer» B. Salicylic acids | |
| 42. |
The overall rate of biotransformation is higher in neonates and infants than in adults. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 43. |
In comparison with children and young adults, elderly adults tend to have a reduced capacity to metabolize drugs. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 44. |
What is enzyme induction? |
| A. | The phenomenon of increased drug metabolizing ability of enzymes by drugs and chemicals |
| B. | The phenomenon of increasing drug bioavailability drugs and chemicals |
| C. | The phenomenon of increasing drug distribution drugs and chemicals |
| D. | The phenomenon of increasing drug concentration for a particular tissue by drugs and chemicals |
| Answer» A. The phenomenon of increased drug metabolizing ability of enzymes by drugs and chemicals | |
| 45. |
Which of the following drugs has self -induction to stimulate their own metabolism? |
| A. | Cortisol |
| B. | Pentobarbital |
| C. | Meprobamate |
| D. | Contraceptives |
| Answer» C. Meprobamate | |
| 46. |
Alcohol is the inducer for which drug? |
| A. | Cortisol |
| B. | Pentobarbital |
| C. | Meprobamate |
| D. | Oral contraceptives |
| Answer» B. Pentobarbital | |
| 47. |
What is the name of the process where structurally same compounds compete for the same site on an enzyme to inhibit that? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» D. Competitive inhibition | |
| 48. |
What is the name of the process where structurally different compounds interact with the enzyme and prevent the metabolism of the drug? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» C. Non-competitive inhibition | |
| 49. |
What is the name of the process where the enzyme amount is decreases due to a decrease in enzyme synthesis? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» B. Repression | |
| 50. |
What is the name of the process where due to nutritional deficiency an enzyme content is decreased? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» A. Altered physiology | |
Done Studing? Take A Test.
Great job completing your study session! Now it's time to put your knowledge to the test. Challenge yourself, see how much you've learned, and identify areas for improvement. Don’t worry, this is all part of the journey to mastery. Ready for the next step? Take a quiz to solidify what you've just studied.