Q.

A 55-year-old man underwent resection of a T2 clear cell renal carcinoma. What is the most likely pathogenesis?

A. activating mutations of the VHL gene
B. MET oncogene activity
C. mutation of p53
D. up-regulated expression of HIF-controlled genes
E. von Hippel–Lindau syndrome
Answer» D. up-regulated expression of HIF-controlled genes
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