McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 1. |
Which one of the following bonds is not generally a bond through which a drug will bind in our body? |
| A. | Hydrogen bond |
| B. | Hydrophobic bond |
| C. | Ionic bond |
| D. | Covalent bond |
| Answer» D. Covalent bond | |
| 2. |
Binding of drugs falls into 2 components those are _______________ |
| A. | Binding of drugs to blood components and to extravascular tissue |
| B. | Binding of drugs to blood components and to other cells |
| C. | Binding of drugs to cells and blood cells |
| D. | Binding of drugs to blood components to bones and cells |
| Answer» A. Binding of drugs to blood components and to extravascular tissue | |
| 3. |
Which one of the following is the correct order of the drugs binding to various plasma protein? |
| A. | Albumin > alpha-1 acid glycoprotein > globulins > lipoproteins |
| B. | Albumin > globulins > lipoproteins > alpha-1 acid glycoprotein |
| C. | Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins |
| D. | Albumin > lipoproteins > globulins > alpha-1 acid glycoprotein |
| Answer» C. Albumin > alpha-1 acid glycoprotein > lipoproteins > globulins | |
| 4. |
Which vitamin molecules will bind to alpha 2 globulin? |
| A. | Vitamin b complexes |
| B. | Vitamin a and vitamin b |
| C. | Vitamin A, D, E, K |
| D. | Steroids bind to alpha 2 globulin, not vitamin |
| Answer» C. Vitamin A, D, E, K | |
| 5. |
What is the molecular weight of human serum albumin? |
| A. | 5000 Dalton |
| B. | 65,000 Dalton |
| C. | 60,000 Dalton |
| D. | 75,000 Dalton |
| Answer» B. 65,000 Dalton | |
| 6. |
HSA comes under which protein family? |
| A. | Globulin |
| B. | Receptor |
| C. | Enzymes |
| D. | Catalyst |
| Answer» B. Receptor | |
| 7. |
What is the name of the drug binding site I of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» D. Warfarin and azapropazone binding site | |
| 8. |
Which one of the below does not belong to the 4 classes of lipoprotein? |
| A. | Chylomicrons |
| B. | Very low-density lipoproteins |
| C. | High-density lipoprotein |
| D. | Fatty acids |
| Answer» D. Fatty acids | |
| 9. |
Which of the given drugs bind to Α1 globulin? |
| A. | Steroidal drugs |
| B. | Vitamins A, D, E, K |
| C. | Ferrous ions |
| D. | Carotenoids |
| Answer» A. Steroidal drugs | |
| 10. |
What is the name of the drug binding site IV of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» A. Tamoxifen binding site | |
| 11. |
Acidic drugs like imipramine, lidocaine bind to alpha 1 Acid Glycoprotein. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 12. |
Which of the given drugs bind to Β2 globulin? |
| A. | Steroidal drugs |
| B. | Vitamins A, D, E, K |
| C. | Ferrous ions |
| D. | Carotenoids |
| Answer» D. Carotenoids | |
| 13. |
What is the name of the drug binding site III of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» B. Digitoxin binding site | |
| 14. |
Which drugs bind to RBC membrane? |
| A. | Pentobarbital |
| B. | Acetazolamide |
| C. | Imipramine |
| D. | Phenytoin |
| Answer» C. Imipramine | |
| 15. |
What is the name of the drug binding site II of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» C. Diazepam binding site | |
| 16. |
Which one of the following factors related to protein-drug binding is not related to drugs? |
| A. | Physicochemical characteristics of a drug |
| B. | The concentration of the drug in the body |
| C. | The affinity of the drug for binding |
| D. | Number of binding sites on the binding agent |
| Answer» D. Number of binding sites on the binding agent | |
| 17. |
Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site? |
| A. | Competition between the drug and the binding site |
| B. | Competition between drugs and normal body constituents |
| C. | Allosteric changes in a protein molecule |
| D. | Inter subject variation |
| Answer» D. Inter subject variation | |
| 18. |
Which of the following factors for protein drug binding is a drug interaction factor? |
| A. | Competition between drugs for the binding site |
| B. | Age |
| C. | Physicochemical characteristics of a drug |
| D. | Physicochemical characteristics of the protein or binding agent |
| Answer» A. Competition between drugs for the binding site | |
| 19. |
Which drugs bind to HSA easily? |
| A. | Cationic drug |
| B. | Anionic drug |
| C. | Lipophilic drug |
| D. | Neutral drug |
| Answer» B. Anionic drug | |
| 20. |
Which drugs easily bind to adipose tissue? |
| A. | Cationic drug |
| B. | Anionic drug |
| C. | Lipophilic drug |
| D. | Neutral drug |
| Answer» C. Lipophilic drug | |
| 21. |
Which drug easily bind to AAG? |
| A. | Cationic drug |
| B. | Anionic drug |
| C. | Lipophilic drug |
| D. | Neutral drug |
| Answer» A. Cationic drug | |
| 22. |
The extent of drug-protein binding can change with both changes in protein and drug concentration. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 23. |
In the equation X= Vd C, what does X stands for? |
| A. | Amount of drug in the blood |
| B. | Amount of drug in plasma |
| C. | Amount of drug in the tablet |
| D. | Amount of drug in the body |
| Answer» D. Amount of drug in the body | |
| 24. |
Only unbound or free drug is capable of being eliminated. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 25. |
Penicillin has short plasma half-life although it can bind to plasma protein rigidly. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 26. |
Displacement interactions are significant in the case of drugs which are more than 95% bound. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 27. |
Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration. |
| A. | CuC |
| B. | C / Cu |
| C. | Cu/C |
| D. | 1/C Cu |
| Answer» C. Cu/C | |
| 28. |
The value of association constant, Ka and the number of binding sites N can be obtained by |
| A. | Direct plot |
| B. | Scatchard plot |
| C. | Klotz plot |
| D. | All of the above |
| Answer» D. All of the above | |
| 29. |
Which of the following drug bind to α1 globulin? |
| A. | Steroids |
| B. | Ferrous ion |
| C. | Carotenoid |
| D. | Vitamin D |
| Answer» A. Steroids | |
| 30. |
What is interaction of phenobarbitone and warfarin? |
| A. | Displacement of warfarin from binding site |
| B. | Decreased absorption of warfarin |
| C. | Increase metabolism of warfarin |
| D. | Decreased metabolism of warfarin |
| Answer» A. Displacement of warfarin from binding site | |
| 31. |
Which process involves alteration of drug distribution? |
| A. | Competitive binding |
| B. | Reduced plasma protein level |
| C. | Both |
| D. | None |
| Answer» C. Both | |
| 32. |
Two most common protein involved in plasma protein binding are |
| A. | Globulin and plasmin |
| B. | Albumin and globulin |
| C. | Fibrin and globulin |
| D. | Plasmin and fibrin |
| Answer» B. Albumin and globulin | |
| 33. |
All of the following displace imipramine from protein binding site except |
| A. | Aspirin |
| B. | Phenytoin |
| C. | Ethosuximide |
| D. | Phenylbutazone |
| Answer» C. Ethosuximide | |
| 34. |
The drugs which are most affected in pregnancy are those having |
| A. | Low protein binding and high Vd |
| B. | High protein binding and low Vd |
| C. | High protein binding and high Vd |
| D. | Low protein binding and low Vd |
| Answer» B. High protein binding and low Vd | |
| 35. |
Most of drugs will bind with which of plasma protein |
| A. | Albumin |
| B. | Globulin |
| C. | Histone |
| D. | Glycoprotein |
| Answer» A. Albumin | |
| 36. |
Which of the following is not highly protein bound drug |
| A. | Barbiturates |
| B. | Phenylbutazone |
| C. | Salicylates |
| D. | Aspirin |
| Answer» D. Aspirin | |
| 37. |
Blood plasma belongs to |
| A. | Interstitial fluid |
| B. | Intracellular fluid |
| C. | Extracellular fluid |
| D. | All of the above |
| Answer» A. Interstitial fluid | |
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