McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 1. |
Non-linear pharmacokinetics is also known as……… |
| A. | dose dependent |
| B. | enzyme capacity limited |
| C. | saturation pharmacokinetics |
| D. | All of the above |
| Answer» D. All of the above | |
| 2. |
The characteristic of non-linear pharmacokinetics include………….. |
| A. | Area under the curve is proportional to the dose |
| B. | Elimination half-life remains constant |
| C. | Area under the curve is not proportional to the dose |
| D. | Amount of drug excreted through remains constant |
| Answer» C. Area under the curve is not proportional to the dose | |
| 3. |
Which of following drug shows non-linearity in hepatic excretion? |
| A. | Carbamazepine |
| B. | Propranolol |
| C. | Penicillin |
| D. | Thiopental |
| Answer» A. Carbamazepine | |
| 4. |
Pharmacokinetics parameters change as per………… of dose administered? |
| A. | Size |
| B. | Route |
| C. | Both of free above |
| D. | None of the above |
| Answer» A. Size | |
| 5. |
Linear Pharmacokinetics is……………… |
| A. | Dose dependent |
| B. | Dose independent |
| C. | Both of the above |
| D. | None of the above |
| Answer» A. Dose dependent | |
| 6. |
Non-linear Pharmacokinetics also called as………… |
| A. | Mixed order |
| B. | Saturated kinetics |
| C. | Capacity Limited |
| D. | All of the above |
| Answer» D. All of the above | |
| 7. |
In…………..Pharmacokinetic parameters for a drug can change with change in dose. |
| A. | Linear Pharmacokinetics |
| B. | Non-linear Pharmacokinetics |
| C. | Both of the above |
| D. | None of the above |
| Answer» B. Non-linear Pharmacokinetics | |
| 8. |
The………………….. is common cause of both dose and time dependent kinetics |
| A. | Capacity limited Process |
| B. | Dose volume |
| C. | Enzyme induction |
| D. | None of the above |
| Answer» C. Enzyme induction | |
| 9. |
When Km << C. In this condition………….. |
| A. | Km – C = C |
| B. | Km + C = C |
| C. | Km + C = Km |
| D. | Km - C = Km |
| Answer» B. Km + C = C | |
| 10. |
Active processes which are Saturable in renal excretion of drug includes……. |
| A. | Active tubular secretion |
| B. | Active tubular reabsorption |
| C. | Both of the above |
| D. | None of the above |
| Answer» C. Both of the above | |
| 11. |
Linear Pharmacokinetics also referred as…………. |
| A. | First-order kinetics |
| B. | Second order kinetics |
| C. | Pseudo order kinetics |
| D. | None of the above in |
| Answer» A. First-order kinetics | |
| 12. |
If the steady-state plasma concentration is directly proportional to the dose, then ……….in the kinetics exists. |
| A. | Linearity |
| B. | Non-linearity |
| C. | Both of the above |
| D. | None of the above |
| Answer» A. Linearity | |
| 13. |
…………..it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R. |
| A. | Accumulation Index |
| B. | Apparent volume of drug distribution |
| C. | Accumulation factor |
| D. | None of the above |
| Answer» A. Accumulation Index | |
| 14. |
Which of the following is correct statement about Nonlinear pharmacokinetics? |
| A. | The pharmacokinetic parameters of a drug will not change when multiple doses of drug are administered |
| B. | The graph of the relationship between the different factors involved (dose, blood plasma concentrations, elimination, etc.) gives a straight line. |
| C. | the plasma drug concentration changes either more or less than would be expected from a change in dose rate. |
| D. | None of the above |
| Answer» C. the plasma drug concentration changes either more or less than would be expected from a change in dose rate. | |
| 15. |
Which of the following Factors causing Non-linearity? |
| A. | Nonlinearity may arise due to pathological alteration at any one of the various pharmacokinetic steps, such as absorption, distribution and/or elimination. |
| B. | Nonlinearity may arise due to Capacity-limited metabolism. |
| C. | Nonlinearity may arise due to alteration in protein binding characteristics |
| D. | All of the above |
| Answer» D. All of the above | |
| 16. |
In Michaelis-Menton Equation, When the value of Km = C |
| A. | rate of process is half (1 /2) the maximum rate. |
| B. | the elimination of most drugs follows first order kinetic |
| C. | the elimination of most drugs follows zero order kinetic |
| D. | the elimination of most drugs follows second order kinetic |
| Answer» A. rate of process is half (1 /2) the maximum rate. | |
| 17. |
Name the different methods used to estimate Km and Vmax graphically. |
| A. | Direct Linear plot |
| B. | Lineweaver —Burke plot or Klotz Plot |
| C. | Graphical Method |
| D. | All of the above |
| Answer» D. All of the above | |
| 18. |
Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 19. |
Which of the following creates nonlinearity in drug distribution and not in drug absorption? |
| A. | When absorption is solubility or dissolution rate-limited |
| B. | When absorption involves carrier-mediated transport systems |
| C. | When a presystemic gut wall or hepatic metabolism attains saturation |
| D. | Saturation of binding sites on plasma proteins |
| Answer» D. Saturation of binding sites on plasma proteins | |
| 20. |
Which one of these is correct Michaelis-Menten equation? |
| A. | –dC/dt = Vmax C/Km+C |
| B. | dC/dt = Vmax C/Km+C |
| C. | –dC/dt = Vmax C/Km |
| D. | –dC/dt = Km+C / Vmax C |
| Answer» A. –dC/dt = Vmax C/Km+C | |
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