McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 1. |
Drug elimination involves....... (ADME are steps of pharmacokinetics) |
| A. | ADME |
| B. | DME |
| C. | ME |
| D. | E only |
| Answer» C. ME | |
| 2. |
Filtration fraction is |
| A. | Fraction of plasma passing through the kidney which is filtered at glomerulus |
| B. | Ratio of iulin clearance to PAH clearance |
| C. | Ration of CFR to RPF |
| D. | None of them |
| Answer» C. Ration of CFR to RPF | |
| 3. |
Creatinine clearance is used as measurement for |
| A. | Glomerular filtration rate |
| B. | Renal excretion rate |
| C. | Passive renal excretion |
| D. | Drug metabolism rate |
| Answer» A. Glomerular filtration rate | |
| 4. |
What is the half life of a drug with a volume of distribution of 100U70kg and a clearance of 7t/hr/70kg |
| A. | 15 hours |
| B. | 10 hours |
| C. | 13.5 hours |
| D. | 5 hours |
| Answer» B. 10 hours | |
| 5. |
A Normal sized adult having hepatic clearance of a drug whose metabolism is limited by the rate of blood flow to the liver would be |
| A. | 60 milliliters/min |
| B. | 120 milliliters/min |
| C. | 650 milliliters/min |
| D. | 1500 milliliters/min |
| Answer» D. 1500 milliliters/min | |
| 6. |
Which process involves alteration in drug excretion? |
| A. | Increased fluid flow |
| B. | Changes in urinary pH |
| C. | Both |
| D. | None |
| Answer» C. Both | |
| 7. |
Which of the following is not a step of renal excretion? |
| A. | Glomerular filtration |
| B. | Tubular filtration |
| C. | Tubular reabsorption |
| D. | Secretion |
| Answer» B. Tubular filtration | |
| 8. |
Renal clearance is expressed as |
| A. | Rate of urinary excretion / Plasma drug concentration |
| B. | Elimination Rate / Plasma drug concentration |
| C. | Rate of urinary excretion / Elimination Rate |
| D. | Elimination Rate |
| Answer» A. Rate of urinary excretion / Plasma drug concentration | |
| 9. |
Glomerular filtration rate would be increased by |
| A. | constriction of the afferent arteriole |
| B. | decrease in afferent arteriolar pressure |
| C. | compression of the renal capsule |
| D. | decrease in the concentration of plasma protein |
| Answer» D. decrease in the concentration of plasma protein | |
| 10. |
The volume of plasma needed each minute to supply a substance at the rate at which it is excreted in the urine is known as the |
| A. | diffusion constant of the substance |
| B. | clearance of the substance |
| C. | extraction ratio of the substance |
| D. | filtration rate of the substance |
| Answer» B. clearance of the substance | |
| 11. |
Nephron is functional unit of………….. |
| A. | Kidney |
| B. | Heart |
| C. | Lung |
| D. | Liver |
| Answer» A. Kidney | |
| 12. |
Hepatic extraction ratio of 0.60 indicates that |
| A. | 40% drug is left after extraction by the liver |
| B. | 60% drug is left after extraction by the liver |
| C. | Only 0.6% drug is removed by the liver |
| D. | None of the above |
| Answer» A. 40% drug is left after extraction by the liver | |
| 13. |
First pas metabolism occurs in: |
| A. | Liver |
| B. | In lungs |
| C. | In kidneys |
| D. | In pancreas |
| Answer» A. Liver | |
| 14. |
The term "biotransformation" includes the following. |
| A. | Accumulation of substances in a fat tissue |
| B. | Process of physicochemical and biochemical alteration of a drug in the body |
| C. | Binding of substances with plasma proteins |
| D. | Accumulation of substances in a tissue |
| Answer» B. Process of physicochemical and biochemical alteration of a drug in the body | |
| 15. |
For the calculation of the volume of distribution (Vd) one take into account: |
| A. | Concentration of a substance in urine |
| B. | Concentration of substance in plasma |
| C. | A daily dose of drug |
| D. | Therapeutic width of drug action |
| Answer» B. Concentration of substance in plasma | |
| 16. |
Biotransformation of a medicinal substance results in: |
| A. | Slower urinary excretion |
| B. | Faster urinary excretion |
| C. | Higher binding to membranes |
| D. | Easier distribution in organism |
| Answer» B. Faster urinary excretion | |
| 17. |
Biotransformation of the drugs is to render them: |
| A. | Less lipid soluble |
| B. | More lipid soluble |
| C. | More pharmacologically active |
| D. | Less ionized |
| Answer» A. Less lipid soluble | |
| 18. |
Select the right statement. |
| A. | Microsomal oxidation results in a decrease of compound toxicity |
| B. | Microsomal oxidation results in an increase of ionization and water solubility of a drug |
| C. | Microsomal oxidation always results in inactivation of a compound |
| D. | Microsomal oxidation results in an increase of lipid solubility of a drug thus its excretion from the organism is facilitated |
| Answer» B. Microsomal oxidation results in an increase of ionization and water solubility of a drug | |
| 19. |
Choose the drug type for which microsomal oxidation is the most prominent. |
| A. | Water soluble |
| B. | Lipid soluble |
| C. | High molecular weight |
| D. | Low molecular weight |
| Answer» B. Lipid soluble | |
| 20. |
Metabolic transformation (phase 1) is: |
| A. | Glucuronide formation |
| B. | Binding to plasma proteins |
| C. | Acetylation and methylation of substances |
| D. | Tr |
| Answer» A. Glucuronide formation | |
| 21. |
Which of the following processes proceeds in the second phase of biotransformation? |
| A. | Acetylation |
| B. | Reduction |
| C. | Oxidation |
| D. | Hydrolysis |
| Answer» A. Acetylation | |
| 22. |
Conjugation is: |
| A. | Process of drug reduction by special enzymes |
| B. | Process of drug oxidation by special oxidases |
| C. | Coupling of a drug with an endogenous substrate |
| D. | Solubilization in lipids |
| Answer» C. Coupling of a drug with an endogenous substrate | |
| 23. |
Tick the drug type for which microsomal oxidation is the most prominent: |
| A. | Lipid soluble |
| B. | Water soluble |
| C. | Low molecular weight |
| D. | High molecular weight |
| Answer» A. Lipid soluble | |
| 24. |
Stimulation of liver microsomal enzymes can: |
| A. | Require the dose increase of some drugs |
| B. | Require the dose decrease of some drugs |
| C. | Prolong the duration of the action of a drug |
| D. | Intensify the unwanted reaction of a drug |
| Answer» A. Require the dose increase of some drugs | |
| 25. |
Conjugation of a drug includes the following except: |
| A. | Glucuronidation |
| B. | Sulfate formation |
| C. | Hydrolysis |
| D. | Methylation |
| Answer» C. Hydrolysis | |
| 26. |
The renal clearance of inulin is used as a measurement of |
| A. | effective renal blood flow |
| B. | rate of renal drug excretion |
| C. | active renal secretion |
| D. | glomerular filtration rate |
| Answer» D. glomerular filtration rate | |
| 27. |
p-aminohippurate is used to measure |
| A. | effective hepatic blood flow |
| B. | effective renal blood flow |
| C. | CFR |
| D. | None of the above |
| Answer» B. effective renal blood flow | |
| 28. |
Total body clearance is |
| A. | the drug elimination rate divided by the plasma drug concentration |
| B. | the drug elimination rate divided by the Vd |
| C. | the amount of drug in body divided by the plasma drug concentration |
| D. | None of the above |
| Answer» A. the drug elimination rate divided by the plasma drug concentration | |
| 29. |
Renal excretion of drug depend on |
| A. | urine flow |
| B. | pH of urine |
| C. | Physicochemical properties of drug |
| D. | All of above |
| Answer» D. All of above | |
| 30. |
For a drug that is eliminated primarily by renal glomerular filtration, the theoretical maximum clearance is approximately |
| A. | 1-2 milliliters/min |
| B. | 12 milliliters/min |
| C. | 120 milliliters/min |
| D. | 1200 milliliters/min |
| Answer» C. 120 milliliters/min | |
| 31. |
Elimination is expressed as follows: |
| A. | Rate of renal tubular reabsorption |
| B. | Clearance speed of some volume of blood from substance |
| C. | Time required decreasing the amount of drug in plasma by one-half |
| D. | Clearance of an organism from a xenobiotic |
| Answer» D. Clearance of an organism from a xenobiotic | |
| 32. |
………….drug shows active tubular secretion. |
| A. | Penicillin |
| B. | Tetracycline |
| C. | Indomethacine |
| D. | None of the above |
| Answer» A. Penicillin | |
| 33. |
Which tissue has the greatest capacity to biotransform of drugs? |
| A. | Kidney |
| B. | Lung |
| C. | Liver |
| D. | Skin |
| Answer» C. Liver | |
| 34. |
The process in which some drugs stimulate their own metabolism is known as |
| A. | Enzyme inhibition |
| B. | Autoinduction |
| C. | Product inhibition |
| D. | None of the above |
| Answer» B. Autoinduction | |
| 35. |
Drugs undergoing first pass metabolism are advised not to be administered through |
| A. | Rectal |
| B. | Oral |
| C. | Transdermal |
| D. | Parenteral |
| Answer» B. Oral | |
| 36. |
………..is defined as volume of blood or plasma from drug is removed in unit time |
| A. | half life |
| B. | clearance |
| C. | volume of distribution |
| D. | biotr |
| Answer» A. half life | |
| 37. |
Tubular reabsorption is achieved by…………… |
| A. | active process |
| B. | passive process |
| C. | Both (a) & (b) |
| D. | none of the above |
| Answer» C. Both (a) & (b) | |
| 38. |
Below mentioned all factors increases plasma elimination half life except |
| A. | Higher protein binding |
| B. | Higher tissue binding |
| C. | Higher apparent Vd |
| D. | Higher ratio renal / hepatic clearance |
| Answer» D. Higher ratio renal / hepatic clearance | |
| 39. |
Hepatic excretion of drug with high extraction ratio is altered by |
| A. | Protein binding |
| B. | Blood flow |
| C. | both (a) & (b) |
| D. | None of the above |
| Answer» B. Blood flow | |
| 40. |
The phenomenon of decreased drug metabolizing ability of the enzymes by drugs is known as …………… |
| A. | enzyme induction |
| B. | enzyme inhibition |
| C. | both (a) & (b) |
| D. | None of the above |
| Answer» B. enzyme inhibition | |
| 41. |
Active tubular reabsorption of drug depends on……………… |
| A. | pH of urine |
| B. | urine flow rate |
| C. | pKa of drug |
| D. | all of the above |
| Answer» D. all of the above | |
| 42. |
Which of the following is not a factor of renal excretion? |
| A. | Blood flow to the kidneys |
| B. | Urine pH |
| C. | Blood pH |
| D. | Disease state |
| Answer» C. Blood pH | |
| 43. |
Which of the following is not a physicochemical factor of drug that can affect the renal excretion? |
| A. | Molecular size |
| B. | Disintegration rate |
| C. | pKa of the drug |
| D. | Lipid solubility |
| Answer» B. Disintegration rate | |
| 44. |
Drugs of molecular range 300-500 Dalton will be excreted out by glomerulus. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 45. |
Clearance is inversely related to volume of distribution. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 46. |
Which drugs cannot be filtered through glomerulus? |
| A. | Drugs bound to plasma proteins |
| B. | Unbound |
| C. | Free drug |
| D. | Below molecular weight of 300 Dalton |
| Answer» A. Drugs bound to plasma proteins | |
| 47. |
Which one is the correct equation to calculate fraction of unbound drug in plasma? |
| A. | Concentration of unbound drug in plasma / total plasma concentration of drug |
| B. | Total plasma concentration of drug / Concentration of unbound drug in plasma |
| C. | 1/Concentration of unbound drug in plasma |
| D. | 1/total plasma concentration of drug |
| Answer» A. Concentration of unbound drug in plasma / total plasma concentration of drug | |
| 48. |
What is total systemic clearance? |
| A. | Sum of clearance from kidney |
| B. | Sum of clearance from kidney and liver |
| C. | Sum of clearance form non-renal clearances |
| D. | Sum of renal and non-renal clearances |
| Answer» D. Sum of renal and non-renal clearances | |
| 49. |
What is the equation for clearance? |
| A. | Elimination rate / plasma drug concentration |
| B. | Plasma drug concentration/elimination rate |
| C. | 1 / Plasma drug concentration |
| D. | 1 / Elimination rate |
| Answer» A. Elimination rate / plasma drug concentration | |
| 50. |
What will be the elimination rate if the clearance is 130ml/min and drug concentration is 0.8 g/ml? |
| A. | 104g/min |
| B. | 140g/min |
| C. | 130g/min |
| D. | 100g/min |
| Answer» A. 104g/min | |
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