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180+ Pharmaceutical Organic Chemistry 3 Solved MCQs
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
| 101. |
Which is the most reactive five membered heterocyclic compound? |
| A. | Pyrrole |
| B. | Furan |
| C. | Thiophene |
| D. | Pyridine |
| Answer» A. Pyrrole | |
| 102. |
What is the product when thiophene reacts with Br2 in benzene? |
| A. | 2-bromothiophene |
| B. | 3-bromothiophene |
| C. | 2,5-dibromothiophene |
| D. | 3,4-dibromothiophene |
| Answer» C. 2,5-dibromothiophene | |
| 103. |
What is the product when pyrrole reacts with Br2 in ethanol? |
| A. | 2,3-dibromopyrrole |
| B. | 2,3,4,5-tetrabromopyrrole |
| C. | 2,5-dibromopyrrole |
| D. | 3,4-dibromopyrrole |
| Answer» B. 2,3,4,5-tetrabromopyrrole | |
| 104. |
What is the name of the following reaction?
|
| A. | Gattermann reaction |
| B. | Riemer tiemann reaction |
| C. | Friedal craft reaction |
| D. | Blanc’s chloromethylation |
| Answer» B. Riemer tiemann reaction | |
| 105. |
What is the name of the following reaction?
|
| A. | Gattermann reaction |
| B. | Riemer tiemann reaction |
| C. | Friedal craft reaction |
| D. | Blanc’s chloromethylation |
| Answer» A. Gattermann reaction | |
| 106. |
What will be the reagent used for the completion of the following reaction?
|
| A. | Concentrated acid |
| B. | Dilute acid |
| C. | Concentrated base |
| D. | Dilute base |
| Answer» B. Dilute acid | |
| 107. |
Which heteroatom present in pyrrole? |
| A. | Oxygen |
| B. | Nitrogen |
| C. | Silicon |
| D. | Sulphur |
| Answer» B. Nitrogen | |
| 108. |
Which heteroatom present in Furan? |
| A. | Oxygen |
| B. | Nitrogen |
| C. | Silicon |
| D. | Sulphur |
| Answer» A. Oxygen | |
| 109. |
Which heteroatom present in thiophene? |
| A. | Nitrogen |
| B. | Silicon |
| C. | Oxygen |
| D. | Sulphur |
| Answer» D. Sulphur | |
| 110. |
Which compound is most basic? |
| A. | Pyridine |
| B. | Pyrrole |
| C. | Imidazole |
| D. | Pyrrolidine |
| Answer» C. Imidazole | |
| 111. |
Which is least basic compound? |
| A. | Pyridine |
| B. | Pyrrole |
| C. | Imidazole |
| D. | Pyrrolidine |
| Answer» B. Pyrrole | |
| 112. |
Which of the following solvents is a heterocyclic compound? |
| A. | DMSO |
| B. | DMF |
| C. | THF |
| D. | None of the above |
| Answer» C. THF | |
| 113. |
Which of the followings statements is correct? |
| A. | Pyrrole has less aromatic character than furan |
| B. | Pyridine is isoelectronic with benzene |
| C. | Pyridine is tertiary amine |
| D. | Pyrrole is strong base |
| Answer» C. Pyridine is tertiary amine | |
| 114. |
What is the correct order of reactivity (most reactive first) of pyrrole, furan and thiophene towards electrophiles? |
| A. | Furan > Pyrrole > Thiophene |
| B. | Pyrrole > Furan > Thiophene |
| C. | Furan > Thiophene > Pyrrole |
| D. | Thiophene > Pyrrole > Furan |
| Answer» B. Pyrrole > Furan > Thiophene | |
| 115. |
Electrophilic substitution in furan usually occurs at: |
| A. | Both the C2 and C3 atom |
| B. | The O atom |
| C. | The C2 atom |
| D. | The C3 atom |
| Answer» C. The C2 atom | |
| 116. |
Nitration of pyrrole is best carried out using: |
| A. | Acetyl nitrate |
| B. | Ammonium nitrate |
| C. | Concentrated nitric and sulphuric acid |
| D. | Nitric acid |
| Answer» A. Acetyl nitrate | |
| 117. |
If you wanted to form 2,3,4,5-tetrabromopyrrole from pyrrole, which of the following conditions would be the best choice? |
| A. | Br2 at 273K |
| B. | Br2 at298 K |
| C. | Br2 in the presence of radical initiator |
| D. | Br2 in the presence of Lewis acid |
| Answer» C. Br2 in the presence of radical initiator | |
| 118. |
Which statement about thiophene is incorrect? |
| A. | The S atom contributes two electrons to the n-system |
| B. | Thiophene is polar |
| C. | Thiophene is less reactive than pyrrole |
| D. | Thiophene is more reactive than furan |
| Answer» D. Thiophene is more reactive than furan | |
| 119. |
Pyrrole undergoes sulfonation in presence of _______to produce pyrrole – 2 – sulfonic acid. |
| A. | Conc. Sulphuric acid |
| B. | SO3 and pyridine |
| C. | Dilute sulphuric acid/pyridine |
| D. | SO3 and ethanol |
| Answer» B. SO3 and pyridine | |
| 120. |
Pyrrole undergoes iodination in presence of Iodine and potassium iodide to produce_____. |
| A. | 2 – iodo pyrrole |
| B. | 3 – iodo pyrrole |
| C. | Tetra iodo pyrrole |
| D. | Tri iodo pyrrole |
| Answer» C. Tetra iodo pyrrole | |
| 121. |
Oxidation of pyrrole in presence of chromium oxide (Cr2O3) and acetic acid produce_______. |
| A. | Maleinimide |
| B. | Maleic acid |
| C. | Pyrrole N-oxide |
| D. | None of the above |
| Answer» A. Maleinimide | |
| 122. |
Pyrrole is reduced by using Zn and acetic acid to get product_______ |
| A. | 2 – pyrroline |
| B. | 3 – pyrroline |
| C. | Pyrrolidine |
| D. | All of the above |
| Answer» B. 3 – pyrroline | |
| 123. |
Which product will be produced when pyrrole undergoes catalytic reduction in presence of hydrogen gas and Ni metal? |
| A. | 2 – pyrroline |
| B. | 3 – pyrroline |
| C. | Pyrrolidine |
| D. | All of the above |
| Answer» C. Pyrrolidine | |
| 124. |
Identify the given heterocyclic compound.
|
| A. | Furan |
| B. | Pyrazole |
| C. | Pyrrole |
| D. | Pyridine |
| Answer» C. Pyrrole | |
| 125. |
Pyrrole potassium on treatment with CO2 under pressure give mixture of 2 and 3 pyrrole – carboxylic acid, identify the reaction. |
| A. | Kolbe-Schmidt reaction |
| B. | Reamer-Tiemann reaction |
| C. | Gattermann Koch reaction |
| D. | Coupling reaction |
| Answer» A. Kolbe-Schmidt reaction | |
| 126. |
Pyrrole is heated with_________ to open the ring and form succinaldehyde dioxime. |
| A. | Concentrated sulphuric acid |
| B. | Strong alkali with pyridine |
| C. | Hydrogen cyanide with HCl |
| D. | Ethanolic hydroxylamine hydrochloride |
| Answer» D. Ethanolic hydroxylamine hydrochloride | |
| 127. |
Atorvastatin, drug useful in CVS disease, contain heterocyclic ring______. |
| A. | Pyrazole |
| B. | Pyrrole |
| C. | Imidazole |
| D. | Purine |
| Answer» B. Pyrrole | |
| 128. |
Bepridil, calcium channel blocker, contain heterocyclic ring_____ |
| A. | Pyrrole |
| B. | Purine |
| C. | Indole |
| D. | Pyridine |
| Answer» A. Pyrrole | |
| 129. |
Ondansetron, anti emetic drug, contain heterocyclic ring______. |
| A. | Thiophene |
| B. | Pyrrole |
| C. | Furan |
| D. | Pyrimidine |
| Answer» B. Pyrrole | |
| 130. |
Which drug(s) possess pyrrole heterocyclic compound from the followings? |
| A. | Captopril |
| B. | Lincomycin |
| C. | Triprolidine |
| D. | All of the above |
| Answer» D. All of the above | |
| 131. |
Identify the following heterocyclic compound.
|
| A. | Furan |
| B. | Thiophene |
| C. | Oxazole |
| D. | Thiazole |
| Answer» A. Furan | |
| 132. |
Complete the following reaction.
|
| A. | Pyrrole |
| B. | Furan |
| C. | Indole |
| D. | Oxazole |
| Answer» B. Furan | |
| 133. |
Which would be the intermediate in the following reaction?
|
| A. | Furan – 2 carboxide |
| B. | Furan- 2 – carbinol |
| C. | Furoic acid |
| D. | None of the above |
| Answer» C. Furoic acid | |
| 134. |
Which would be the product when furan undergoes sulfonation in the presence of SO3 and pyridine? |
| A. | Furan – 2 – sulfolic acid |
| B. | Furan – 3 – sulfonic acid |
| C. | Mixture of (a) & (b) |
| D. | None of the above |
| Answer» A. Furan – 2 – sulfolic acid | |
| 135. |
Which reagent is used for the nitration of furan? |
| A. | Conc. Nitric acid and sulphuric acid |
| B. | Acetyl nitrate |
| C. | Nitrobenzene |
| D. | Dilute nitric acid with benzene |
| Answer» B. Acetyl nitrate | |
| 136. |
Friedel craft acetylation of furan by using acetic anhydride is carried out in the presence of catalyst______. |
| A. | AlCl3 |
| B. | FeCl3 |
| C. | BF3 |
| D. | LIAlH4 |
| Answer» C. BF3 | |
| 137. |
Identify the reaction: when furan react with aryl diazonium chloride in the presence of strong alkali to produce 2 – aryl furan. |
| A. | Mercuration |
| B. | Gattermann Koch reaction |
| C. | Kolbe reaction |
| D. | Gomberg reaction |
| Answer» D. Gomberg reaction | |
| 138. |
Bromination of furan by using Br2 will produce_________. |
| A. | 2 – bromo furan |
| B. | 3 – bromo furan |
| C. | 2,5 – dibromo furan |
| D. | None of the above |
| Answer» D. None of the above | |
| 139. |
Identify the following reaction:
|
| A. | Cannizaro reaction |
| B. | Benzoin condensation |
| C. | Gomberg reaction |
| D. | Mercuration |
| Answer» A. Cannizaro reaction | |
| 140. |
Identify the following reaction:
|
| A. | Gomberg reaction |
| B. | Reamer tiemann reaction |
| C. | Benzoin condensation |
| D. | Aldol condensation |
| Answer» C. Benzoin condensation | |
| 141. |
Complete the reaction:
|
| A. | Br2 |
| B. | HBr |
| C. | KBr in alcohol |
| D. | NaBr in pyridine |
| Answer» A. Br2 | |
| 142. |
Furan on treatment with acid undergoes protonation and form________. |
| A. | Protonated furan |
| B. | Polymeric product |
| C. | Dihydro furan |
| D. | None of the above |
| Answer» B. Polymeric product | |
| 143. |
Oxidation of furan produces_________. |
| A. | Furan oxide |
| B. | Furfural |
| C. | Furfuric acid |
| D. | Succinaldehyde |
| Answer» D. Succinaldehyde | |
| 144. |
Catalytic reduction of furan gives______ |
| A. | 2,3 – dihydro furan |
| B. | 2,5 – dihydro furan |
| C. | Tetra hydro furan |
| D. | 3,4 – dihydro furan |
| Answer» C. Tetra hydro furan | |
| 145. |
Prazocin, sympatholytic drug contain__________heterocyclic ring. |
| A. | Furan |
| B. | Pyrrole |
| C. | Oxazole |
| D. | Indole |
| Answer» A. Furan | |
| 146. |
Which drug of following does not contain furan ring? |
| A. | Furazolidone |
| B. | Lorpiprazole |
| C. | Terazocin |
| D. | Dantrolene |
| Answer» B. Lorpiprazole | |
| 147. |
Amiodarone, antiarrhythmic agent, possess_________ heterocyclic ring. |
| A. | Pyridine |
| B. | Furan |
| C. | Thiophene |
| D. | Purine |
| Answer» B. Furan | |
| 148. |
From the followings, which drug contain furan heterocyclic ring? |
| A. | Furazolidine |
| B. | Nitrofurantoin |
| C. | Fluticazone |
| D. | All of the above |
| Answer» D. All of the above | |
| 149. |
Ranitidine, H2 receptor antagonist, possess________heterocyclic ring. |
| A. | Acridine |
| B. | Azepine |
| C. | Pyridine |
| D. | Furan |
| Answer» D. Furan | |
| 150. |
Pilocarpine, cholinergic agonist, contains________heterocyclic ring. |
| A. | Furan |
| B. | Pyrrole |
| C. | Thiophene |
| D. | Purine |
| Answer» A. Furan | |
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