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180+ Pharmaceutical Organic Chemistry 3 Solved MCQs
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
| 151. |
Which heterocyclic ring is present in Diloxanide furoate, anti protozoal drug? |
| A. | Acridine |
| B. | Thiazole |
| C. | Furan |
| D. | Thiophene |
| Answer» C. Furan | |
| 152. |
Which heterocyclic ring is present in Rofecoxib, NSAID? |
| A. | Pyrrole |
| B. | Furan |
| C. | Purine |
| D. | Indole |
| Answer» B. Furan | |
| 153. |
Which is the following heterocyclic compound?
|
| A. | Thiophene |
| B. | Thiazole |
| C. | Furan |
| D. | Pyrrole |
| Answer» A. Thiophene | |
| 154. |
Complete the reaction:
|
| A. | Thiazole |
| B. | Oxazole |
| C. | Thiphene |
| D. | Furan |
| Answer» C. Thiphene | |
| 155. |
What would be the product of following reaction?
|
| A. | Thiophene |
| B. | Thiazole |
| C. | Purine |
| D. | Pyrimidine |
| Answer» A. Thiophene | |
| 156. |
What would be the appropriate reaction condition for the following reaction;
|
| A. | SO2/AlCl3/673K |
| B. | H2S/AlCl3/273K |
| C. | H2S/Al2O3/673K |
| D. | Sulphur/heat |
| Answer» C. H2S/Al2O3/673K | |
| 157. |
What is not true about thiophene from the following sentences? |
| A. | Thiophene shows aromaticity. |
| B. | Thiophene contains oxygen heteroatom. |
| C. | Thiophene has diene like structure. |
| D. | Thiophene has a flat pentagonal ring. |
| Answer» B. Thiophene contains oxygen heteroatom. | |
| 158. |
Which is the true statement from followings? |
| A. | Thiophene is more stable than pyrrole |
| B. | Thiophene is more stable than furan |
| C. | Both (a) & (b) |
| D. | None of the above |
| Answer» C. Both (a) & (b) | |
| 159. |
Thiophene shows electrophilic substitution reactions mainly at position___. |
| A. | C2 |
| B. | C3 |
| C. | C4 |
| D. | C5 |
| Answer» A. C2 | |
| 160. |
Which condition is appropriate for the nitration of thiophene? |
| A. | Acetyl nitrate |
| B. | Nitric acid +acetic anhydride |
| C. | Concentrated nitric acid |
| D. | Sodium nitrate |
| Answer» B. Nitric acid +acetic anhydride | |
| 161. |
Identify the reaction: When thiophene react with dimethyl formamide in the presence of POCl3, it will produce thiophene – 2 – carboxaldehyde. |
| A. | Kolbe reaction |
| B. | Canizzaro reaction |
| C. | Gattermann Koch reaction |
| D. | Vilsmeir – Hoack reaction |
| Answer» D. Vilsmeir – Hoack reaction | |
| 162. |
Sulfonation of thiophene can be carried out by using______________. |
| A. | SO3 +Conc. HCl |
| B. | Dilute Sulphuric acid |
| C. | Concentrated Sulphuric acid |
| D. | SO3 + HNO3 |
| Answer» C. Concentrated Sulphuric acid | |
| 163. |
Chloromethylation of thiophene is carried out with HCHO & HCl, it will produce_______. |
| A. | 2- chloromethyl thiophene |
| B. | 2- methyl thiophene |
| C. | 2- chloro thiophene |
| D. | 2-chloro, 5- methyl thiophene |
| Answer» A. 2- chloromethyl thiophene | |
| 164. |
Complete the reaction:
|
| A. | Cl2 |
| B. | SO3 + HCl |
| C. | Cl2 + HCl |
| D. | SO2Cl2 |
| Answer» D. SO2Cl2 | |
| 165. |
What will be the product of the following reaction?
|
| A. | 2- iodo thiophene |
| B. | 2,5 – di iodo thiophene |
| C. | 2,3 – di iodo thiophene |
| D. | Tetra iodo thiophene |
| Answer» A. 2- iodo thiophene | |
| 166. |
What will be the product of the following reaction?
|
| A. | 5 – bromo thiophene |
| B. | 3- bromo thiophene |
| C. | 2 – bromo thiophene |
| D. | 2,5 – di bromo thiophene |
| Answer» C. 2 – bromo thiophene | |
| 167. |
Chlorination of thiophene by using Chlorine at 243K will form__________. |
| A. | 2- chloro thiophene + 5- chloro thiophene |
| B. | 2,5 – dichloro thiophene |
| C. | 2- chloro thiophene + 2,5- dichloro thiophene |
| D. | Tetra chloro thiophene |
| Answer» C. 2- chloro thiophene + 2,5- dichloro thiophene | |
| 168. |
Bromination of thiophene by using Bromine in benzene will produce________ |
| A. | 5 – bromo thiophene |
| B. | 3- bromo thiophene |
| C. | 2 – bromo thiophene |
| D. | 2,5 – di bromo thiophene |
| Answer» D. 2,5 – di bromo thiophene | |
| 169. |
Identify the reaction:
|
| A. | Reimer Tiemann reaction |
| B. | Canizzaro reaction |
| C. | Vilsmeir – Hoack reaction |
| D. | Benzoin condensation |
| Answer» B. Canizzaro reaction | |
| 170. |
What would be the reducing agent for the following reduction of thiophene?
|
| A. | Na + ammonia |
| B. | Hydrogen gas + Ni |
| C. | Pd + ammonia |
| D. | Pd + Hydrogen gas |
| Answer» A. Na + ammonia | |
| 171. |
Thiophene on catalytic reduction with large amount of palladium (Pd) gives_________. |
| A. | 2 – thiolen |
| B. | 3 – thiolen |
| C. | n – Butane |
| D. | Tetra hydro thiophene |
| Answer» D. Tetra hydro thiophene | |
| 172. |
Thiophene is reduced with Raney nickel (Ni) which results in removal of sulphur to form______. |
| A. | 2 – thiolen |
| B. | 3 – thiolen |
| C. | n – Butane |
| D. | Tetra hydro thiophene |
| Answer» C. n – Butane | |
| 173. |
Which drug(s) contain thiophene ring in its(their) structure? |
| A. | Cephalothin |
| B. | Cefoxitin |
| C. | Temocillin |
| D. | All of the above |
| Answer» D. All of the above | |
| 174. |
Which drug(s) contain thiophene ring in its(their) structure? |
| A. | Tinoridine |
| B. | Tiaprofenic |
| C. | Tenoxicam |
| D. | All of the above |
| Answer» D. All of the above | |
| 175. |
Thiophene & its derivatives show following pharmacological activity. |
| A. | Sedative |
| B. | Hypnotic |
| C. | Anticonvulsant activity |
| D. | All of the above |
| Answer» D. All of the above | |
| 176. |
Clotiazepam, CNS active agent, possess __________ heterocyclic ring. |
| A. | Thiophene |
| B. | Oxazole |
| C. | Pyridine |
| D. | Pyrrole |
| Answer» A. Thiophene | |
| 177. |
Ticlopidine, anticoagulant activity, contain _________ heterocyclic compound. |
| A. | Thiazole |
| B. | Thiophene |
| C. | Furan |
| D. | Indole |
| Answer» B. Thiophene | |
| 178. |
Which pharmacological effect is not produced by thiophene derivatives? |
| A. | Anticoagulants |
| B. | Diuretics |
| C. | Coagulants |
| D. | Anti asthmatics |
| Answer» C. Coagulants | |
| 179. |
Thiophene probably undergoes to ___________ reaction. |
| A. | Electrophilic substitution |
| B. | Nucleophilic substitution |
| C. | Electrophilic addition |
| D. | Nucleophilic addition |
| Answer» A. Electrophilic substitution | |
| 180. |
Furan probably undergoes to ___________ reaction. |
| A. | Electrophilic substitution |
| B. | Nucleophilic substitution |
| C. | Electrophilic addition |
| D. | Nucleophilic addition |
| Answer» A. Electrophilic substitution | |
| 181. |
Pyrrole probably undergoes to ___________ reaction. |
| A. | Electrophilic substitution |
| B. | Nucleophilic substitution |
| C. | Electrophilic addition |
| D. | Nucleophilic addition |
| Answer» A. Electrophilic substitution | |
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