McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
Chapters
| 101. |
Diazepam gets metabolised into Hydroxydiazepam is example of |
| A. | Oxidation at allylic carbon atom |
| B. | Oxidation at the carbon alpha to carbonyl and imino group |
| C. | Oxidation at benzylic carbon atom |
| D. | Aromatic and Side chain Hydroxylation |
| Answer» B. Oxidation at the carbon alpha to carbonyl and imino group | |
| 102. |
__________reaction is most common in drugs having ester or amide functional groups |
| A. | Oxidative reactions |
| B. | Reduction |
| C. | Hydrolysis |
| D. | Phase I |
| Answer» C. Hydrolysis | |
| 103. |
UDPGA means.... |
| A. | Urane diphospho -a- D glucuronic acid |
| B. | Uridine diphospho -a- D glucuronic acid |
| C. | Uridine diphospho-D glucuronic acid |
| D. | Uric diphospho -a- D glucuronic acid |
| Answer» B. Uridine diphospho -a- D glucuronic acid | |
| 104. |
Which of the following statement is false? |
| A. | D-glucuronic acid is easily available |
| B. | Several functional groups can be easily linked with the D-glucuronic acid |
| C. | Conjugation with D-glucuronic acid occurs to a high degree |
| D. | Whole animal kingdom have the common ability to produce D-glucuronic acid |
| Answer» D. Whole animal kingdom have the common ability to produce D-glucuronic acid | |
| 105. |
Which enzyme is of the utmost importance for the 2nd step in the formation of Glucuronide? |
| A. | Esterase |
| B. | Amidases |
| C. | Transferase |
| D. | UDP-glucuronyl tr |
| Answer» A. Esterase | |
| 106. |
What is the site of first-pass metabolism before molecules reach systemic circulation? |
| A. | Kidney |
| B. | Throat |
| C. | Liver |
| D. | Intestine |
| Answer» D. Intestine | |
| 107. |
What plays a major role in extra-hepatic metabolism and contains CYP3A4 isozyme and P-glycoprotein? |
| A. | Kidney |
| B. | Throat |
| C. | Liver |
| D. | Intestine |
| Answer» C. Liver | |
| 108. |
What test uses microsomal extracts from the ER for in-vitro drug metabolism studies? |
| A. | Ames test |
| B. | Biochemical tests |
| C. | Serology |
| D. | Polymorphisms |
| Answer» A. Ames test | |
| 109. |
Which of the following are protein components of the cytochrome P450 system? |
| A. | Heme protein CYP450 |
| B. | NADH-CYP450 reductase |
| C. | NADPH-CYP450 reductase |
| D. | A and B E. A and C |
| Answer» A. Heme protein CYP450 | |
| 110. |
Which of the following statements is not true about cytochrome P450 enzymes? |
| A. | They contain haem and magnesium. |
| B. | They belong to a general class of enzymes called monooxygenases. |
| C. | There are over 30 different cytochrome P450 enzymes. |
| D. | Variation in cytochrome P450 enzyme profile between individuals can explain individual variation in drug susceptibility. |
| Answer» A. They contain haem and magnesium. | |
| 111. |
What is not a xenobiotic? |
| A. | Plant toxins |
| B. | Drugs |
| C. | Steroids |
| D. | Environmental pollutants |
| Answer» C. Steroids | |
| 112. |
What cytochrome P450 isozyme is most abundantly expressed in the human liver and intestines? |
| A. | CYP1A1 |
| B. | CYP3A4 |
| C. | CYP2C9 |
| D. | CYP2D6 |
| Answer» B. CYP3A4 | |
| 113. |
Which of the following is an antiarrhythmic drug that is a calcium channel blocker? |
| A. | Lidocaine |
| B. | Nitroglycerin |
| C. | Nifedipine |
| D. | Codeine |
| Answer» C. Nifedipine | |
| 114. |
What drug should not be given to a patient that is a poor CYP2D6 metabolizer? |
| A. | Codeine |
| B. | Lidocaine |
| C. | Nifedipine |
| D. | Nitroglycerin |
| Answer» A. Codeine | |
| 115. |
What injection is administered directly into systemic circulation causing rapid distribution? |
| A. | Intramuscular |
| B. | Intravenous |
| C. | Intracerebral |
| D. | Intraspinal |
| Answer» B. Intravenous | |
| 116. |
Where is Protonsil converted to Sulfanilamide? |
| A. | Liver |
| B. | Gut |
| C. | Kidney |
| D. | Colon |
| Answer» B. Gut | |
| 117. |
What are xenobiotics? |
| A. | Another form of antibiotics |
| B. | A form of nutrient |
| C. | Nutrients which kill the gut harmful microbes |
| D. | Anything that is not nutrients and enters the body through different routes |
| Answer» D. Anything that is not nutrients and enters the body through different routes | |
| 118. |
What is the active form of salicylic acid? |
| A. | Sialic acid |
| B. | Salic acid |
| C. | Salicylic acid |
| D. | Salicycle acid |
| Answer» C. Salicylic acid | |
| 119. |
What is the inactive form of Codeine? |
| A. | Codene |
| B. | Codane |
| C. | Morphine |
| D. | Poppy |
| Answer» C. Morphine | |
| 120. |
Which of the following is the correct decreasing order of drug metabolism? |
| A. | Liver > lungs > kidneys > intestine > placenta > skin > adrenals |
| B. | Liver > lungs > kidneys > intestine > adrenals > placenta > skin |
| C. | Liver > kidneys > lungs > intestine > placenta > adrenals > skin |
| D. | Liver > lungs > intestine > kidneys > placenta > adrenals > skin |
| Answer» A. Liver > lungs > kidneys > intestine > placenta > skin > adrenals | |
| 121. |
Which one of the following is reactive and a known carcinogenic? |
| A. | Cytochrome P-450 |
| B. | Catechol |
| C. | Glutathione |
| D. | Arene oxide |
| Answer» D. Arene oxide | |
| 122. |
Which of the following is not an example of a drug undergoing acetylation reaction? |
| A. | Hydrazine |
| B. | Salicylic acids |
| C. | Sulphonamides |
| D. | Histamines |
| Answer» B. Salicylic acids | |
| 123. |
The overall rate of biotransformation is higher in neonates and infants than in adults. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 124. |
In comparison with children and young adults, elderly adults tend to have a reduced capacity to metabolize drugs. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 125. |
What is enzyme induction? |
| A. | The phenomenon of increased drug metabolizing ability of enzymes by drugs and chemicals |
| B. | The phenomenon of increasing drug bioavailability drugs and chemicals |
| C. | The phenomenon of increasing drug distribution drugs and chemicals |
| D. | The phenomenon of increasing drug concentration for a particular tissue by drugs and chemicals |
| Answer» A. The phenomenon of increased drug metabolizing ability of enzymes by drugs and chemicals | |
| 126. |
Which of the following drugs has self -induction to stimulate their own metabolism? |
| A. | Cortisol |
| B. | Pentobarbital |
| C. | Meprobamate |
| D. | Contraceptives |
| Answer» C. Meprobamate | |
| 127. |
Alcohol is the inducer for which drug? |
| A. | Cortisol |
| B. | Pentobarbital |
| C. | Meprobamate |
| D. | Oral contraceptives |
| Answer» B. Pentobarbital | |
| 128. |
What is the name of the process where structurally same compounds compete for the same site on an enzyme to inhibit that? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» D. Competitive inhibition | |
| 129. |
What is the name of the process where structurally different compounds interact with the enzyme and prevent the metabolism of the drug? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» C. Non-competitive inhibition | |
| 130. |
What is the name of the process where the enzyme amount is decreases due to a decrease in enzyme synthesis? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» B. Repression | |
| 131. |
What is the name of the process where due to nutritional deficiency an enzyme content is decreased? |
| A. | Altered physiology |
| B. | Repression |
| C. | Non-competitive inhibition |
| D. | Competitive inhibition |
| Answer» A. Altered physiology | |
| 132. |
Which one of the following is not an environmental agent to decrease drug metabolizing ability? |
| A. | DDT |
| B. | Cigarette smoke |
| C. | Organophosphate insecticides |
| D. | Methacholine |
| Answer» D. Methacholine | |
| 133. |
What is polygenic control of drugs? |
| A. | Drug controlling seen in an individual |
| B. | Drug controlling seen in twins |
| C. | Drug controlling seen in between different species |
| D. | Drug controlling seen in a particular population |
| Answer» B. Drug controlling seen in twins | |
| 134. |
Differences observed in metabolism of drug among different races is known as |
| A. | Pharmacogenetics |
| B. | Ethnic variations |
| C. | Discontinues variation |
| D. | Polygenic control |
| Answer» B. Ethnic variations | |
| 135. |
Which age group is known as the neonates? |
| A. | Up to 2 months |
| B. | Up to 2 years |
| C. | Up to 6 months |
| D. | Up to 1 year |
| Answer» A. Up to 2 months | |
| 136. |
Which age group metabolizes drugs faster than the adults? |
| A. | Between 1-12 year |
| B. | Between 1-15 year |
| C. | Between 6-12 year |
| D. | Between 12-18 year |
| Answer» A. Between 1-12 year | |
| 137. |
Fat-free diet depresses cytochrome P-450 level. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 138. |
Maternal drug metabolizing ability increases in the later stage of pregnancy. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 139. |
Enzyme activity is maximum during the early morning. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 140. |
Intermediate of aromatic hydroxylation is |
| A. | Arene |
| B. | Epoxide |
| C. | Aldehyde |
| D. | Ketone |
| Answer» B. Epoxide | |
| 141. |
Oxidation of Propranolol results in |
| A. | 2-hydroxy propranolol |
| B. | 3-hydroxy propranolol |
| C. | 4-hydroxy propranolol |
| D. | 2,2-Dihydroxy propranolol |
| Answer» C. 4-hydroxy propranolol | |
| 142. |
Oxidation of olefin results in |
| A. | Aldehyde |
| B. | Ketone |
| C. | Diol |
| D. | Carboxylic acid |
| Answer» C. Diol | |
| 143. |
Oxidation of Tolbutamide is the example of |
| A. | Oxidation of Olefin |
| B. | Oxidation of Aliphatic carbon |
| C. | Oxidation of Benzylic carbon |
| D. | Oxidation of Allylic carbon |
| Answer» C. Oxidation of Benzylic carbon | |
| 144. |
Carbon atom adjacent to olefinic double bond is known as |
| A. | Alicyclic carbon |
| B. | Aliphatic carbon |
| C. | Benzylic carbon |
| D. | Allylic carbon |
| Answer» D. Allylic carbon | |
| 145. |
Oxidation of Hexobarbital results in |
| A. | 2-hydroxy Hexobarbital |
| B. | 3-hydroxy Hexobarbital |
| C. | 4-hydroxy Hexobarbital |
| D. | 2,3-Dihydroxy Hexobarbital |
| Answer» B. 3-hydroxy Hexobarbital | |
| 146. |
Given reaction is the example of_________ |
| A. | Oxidation of Carbon atom alpha to Carbonyl and Imine |
| B. | Oxidation of Aliphatic carbon |
| C. | Oxidation of Benzylic carbon |
| D. | Oxidation of Allylic carbon |
| Answer» A. Oxidation of Carbon atom alpha to Carbonyl and Imine | |
| 147. |
ω – oxidation of Valproic acid results in |
| A. | 2-hydroxy valproic acid |
| B. | 3-hydroxy valproic acid |
| C. | 4-hydroxy valproic acid |
| D. | 5-hydroxy valproic acid |
| Answer» D. 5-hydroxy valproic acid | |
| 148. |
ω1 – oxidation of Valproic acid results in |
| A. | 2-hydroxy valproic acid |
| B. | 3-hydroxy valproic acid |
| C. | 4-hydroxy valproic acid |
| D. | 5-hydroxy valproic acid |
| Answer» C. 4-hydroxy valproic acid | |
| 149. |
Given reaction is the example of_________ |
| A. | Oxidation of Alicyclic carbon |
| B. | Oxidation of Aliphatic carbon |
| C. | Oxidation of Benzylic carbon |
| D. | Oxidation of Allylic carbon |
| Answer» A. Oxidation of Alicyclic carbon | |
| 150. |
Desulphuration of given drug results in _______ |
| A. | Phenobarbitone |
| B. | Paroxon |
| C. | Sulphanilamide |
| D. | PABA |
| Answer» A. Phenobarbitone | |
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