McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
Chapters
| 51. |
Methyl Prednisolone is water insoluble but its which salt is water soluble? |
| A. | Sodium |
| B. | Hydrochloride |
| C. | Salicylate |
| D. | Palmitate |
| Answer» A. Sodium | |
| 52. |
Phenobarbitone is water insoluble but its which salt is water soluble? |
| A. | Sodium |
| B. | Hydrochloride |
| C. | Salicylate |
| D. | Palmitate |
| Answer» A. Sodium | |
| 53. |
Which ester of Chloramphenicol is prepared to mask its bitter taste? |
| A. | Sodium |
| B. | Hydrochloride |
| C. | Salicylate |
| D. | Palmitate |
| Answer» D. Palmitate | |
| 54. |
Generally drugs are absorbed in which form? |
| A. | In ionized form |
| B. | In unionized form |
| C. | In both of abone form |
| D. | In none of above form |
| Answer» B. In unionized form | |
| 55. |
Most weakly acidic drugs (pKa < 2) are absorbed from |
| A. | Stomach |
| B. | Intestine |
| C. | Stomach and Intestine |
| D. | They Can’t be absorbed |
| Answer» A. Stomach | |
| 56. |
Most weakly basic drugs (pKa > 8) are absorbed from |
| A. | Stomach |
| B. | Intestine |
| C. | Stomach and Intestine |
| D. | They Can’t be absorbed |
| Answer» B. Intestine | |
| 57. |
Absorption of neutral drugs (pKa 6- 8) is independent of pH. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 58. |
Which form of barbituric acid has CNS activity? |
| A. | 1 |
| B. | 2 |
| C. | 3 |
| D. | All |
| Answer» C. 3 | |
| 59. |
Addition of non-polar group _________ partition co-efficient |
| A. | Improves |
| B. | Reduces |
| C. | No effect on |
| D. | none |
| Answer» A. Improves | |
| 60. |
Gentamicin, streptokinase can be given |
| A. | Orally |
| B. | Parentrally |
| C. | Both of above |
| D. | None of above |
| Answer» B. Parentrally | |
| 61. |
Distance between H-bond is |
| A. | 2.3- 5.2 A° |
| B. | 1.2 – 2.5 A° |
| C. | 2.5 – 3.2 A° |
| D. | 3.2 – 8.5 A° |
| Answer» C. 2.5 – 3.2 A° | |
| 62. |
Angel of H-bond |
| A. | 1.3 – 1.8° |
| B. | 13-18° |
| C. | 130 – 180 ° |
| D. | 1300 – 1800 ° |
| Answer» C. 130 – 180 ° | |
| 63. |
Strength of H-bond is |
| A. | 1-7 Kcal/mol |
| B. | 10-70 Kcal/mol |
| C. | 10-17 Kcal/mol |
| D. | 17-70 Kcal/mol |
| Answer» A. 1-7 Kcal/mol | |
| 64. |
p-nitrophenol contains |
| A. | Intramolecular H-bond |
| B. | Intermolecular H-bond |
| C. | Both of above |
| D. | None of above |
| Answer» B. Intermolecular H-bond | |
| 65. |
Which one of the following factors related to protein-drug binding is not related to drugs? |
| A. | Physicochemical characteristics of a drug |
| B. | The concentration of the drug in the body |
| C. | The affinity of the drug for binding |
| D. | Number of binding sites on the binding agent |
| Answer» D. Number of binding sites on the binding agent | |
| 66. |
Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site? |
| A. | Competition between the drug and the binding site |
| B. | Competition between drugs and normal body constituents |
| C. | Allosteric changes in a protein molecule |
| D. | Inter subject variation |
| Answer» D. Inter subject variation | |
| 67. |
Which of the following factors for protein drug binding is a drug interaction factor? |
| A. | Competition between drugs for the binding site |
| B. | Age |
| C. | Physicochemical characteristics of a drug |
| D. | Physicochemical characteristics of the protein or binding agent |
| Answer» A. Competition between drugs for the binding site | |
| 68. |
Only unbound or free drug is capable of being eliminated. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 69. |
Plasma proteins bound with drugs by formation of |
| A. | Hydrogen bonding |
| B. | Hydrophobc bonding |
| C. | Vander-waals force |
| D. | All |
| Answer» D. All | |
| 70. |
The most significant protein involved in binding with a drug is |
| A. | Albumin |
| B. | Glycoprotein |
| C. | Lipoprotein |
| D. | Globulin |
| Answer» A. Albumin | |
| 71. |
The most abundant plasma protein is |
| A. | Albumin (HAS – Human serum albumin) |
| B. | Glycoprotein |
| C. | Lipoprotein |
| D. | Globulin |
| Answer» A. Albumin (HAS – Human serum albumin) | |
| 72. |
Chelating agent Dimercaprol is used in the treatment of |
| A. | Lead poisoning |
| B. | Vanadium poisoning |
| C. | Arsenic poisoning |
| D. | All of above |
| Answer» C. Arsenic poisoning | |
| 73. |
In Lead and vanadium poisoning, which chelating agent is used as an antidote? |
| A. | Disodium EDTA |
| B. | Haemoglobin |
| C. | Cyanocobalamine |
| D. | Dimercaprol |
| Answer» A. Disodium EDTA | |
| 74. |
Absorption of Tetracycline is reduced in the presence of milk because of |
| A. | Hydrogen bonding |
| B. | Protein binding |
| C. | Ionization |
| D. | Chelation |
| Answer» D. Chelation | |
| 75. |
Functional groups of same valance and ring equivalents are known as |
| A. | Classical Bioisosteres |
| B. | Non- Classical Bioisosteres |
| C. | Enantiomer |
| D. | Geometric isomer |
| Answer» A. Classical Bioisosteres | |
| 76. |
Bioisosteres have |
| A. | Same physical properties |
| B. | Same chemical properties |
| C. | Similar biological properties |
| D. | All of above |
| Answer» D. All of above | |
| 77. |
R (-) Epinephrine shows 3 point of interaction with receptor while S (+)Epinephrine shows 2 point of interaction with receptor. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 78. |
(+) Warfarin is _____times more potent than (-) Warfarin. |
| A. | 2 |
| B. | 3 |
| C. | 4 |
| D. | 5 |
| Answer» D. 5 | |
| 79. |
(+) Sotalol is beta blocker while (-) Sotalol is |
| A. | beta blocker |
| B. | Analgesic |
| C. | Antidepressant |
| D. | Antiarrhythmic |
| Answer» D. Antiarrhythmic | |
| 80. |
D-Penicillamine is antiarthritic while L-Penicillamine is |
| A. | Antiarthritic |
| B. | Antiarrhythmic |
| C. | Antidepressant |
| D. | Toxic |
| Answer» D. Toxic | |
| 81. |
D-Asparagine has sweet taste while L-Asparagine has |
| A. | Sweet taste |
| B. | Sour Taste |
| C. | Bitter Taste |
| D. | Tasteless |
| Answer» D. Tasteless | |
| 82. |
Biotransformation of drugs is defined as the conversion from one physical form to another. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 83. |
The drug biotransformation is a detoxification process. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 84. |
Phase 1 reactions are also known as a synthetic reaction. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 85. |
The phase I reactions are detoxification pathways. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 86. |
The phase II reactions are detoxification pathways. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 87. |
Following are the Phase I reactions except ____________ |
| A. | Oxidative reactions |
| B. | Hydrolytic reactions |
| C. | Reductive reactions |
| D. | Sulphide reactions |
| Answer» D. Sulphide reactions | |
| 88. |
Which of the following statements is the closest description of Phase I metabolism? |
| A. | Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites |
| B. | Reactions which occur in the blood supply. |
| C. | Reactions which add a polar functional group to a drug. |
| D. | Reactions which occur in the gut wall. |
| Answer» C. Reactions which add a polar functional group to a drug. | |
| 89. |
Which of the following statements is the closest description of Phase II metabolism? |
| A. | Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites. |
| B. | Reactions which occur in the blood supply. |
| C. | Reactions which add a polar functional group to a drug. |
| D. | Reactions which occur in the gut wall. |
| Answer» A. Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites. | |
| 90. |
Which of the following is not a characteristic of the moieties that are transferred to the substrate in phase II reactions? |
| A. | Simple endogenous molecules are transferred |
| B. | Large molecular sized groups are attached |
| C. | Strong polar groups are attached |
| D. | Strong nonpolar groups are attached |
| Answer» D. Strong nonpolar groups are attached | |
| 91. |
Which of the following enzymes is not involved in catalyzing Phase I metabolic reaction? |
| A. | Flavin-containing monooxygenases |
| B. | Oxidation of alkyl groups |
| C. | Glucuronyl transferase |
| D. | Esterases |
| Answer» C. Glucuronyl transferase | |
| 92. |
Which of the following reactions is not a Phase I metabolic transformation? |
| A. | Reduction of ketones |
| B. | Conjugation to alcohols |
| C. | Monoamine oxidases |
| D. | Esterhydrolysis |
| Answer» B. Conjugation to alcohols | |
| 93. |
What is the major end product of oxidation of aromatic carbon atoms? |
| A. | Arenols |
| B. | Catechol |
| C. | Glutathione |
| D. | Arene oxide |
| Answer» A. Arenols | |
| 94. |
Which of the following is not a common N containing functional groups which undergo reduction reactions? |
| A. | Nitro compounds |
| B. | Azo compounds |
| C. | N-oxide compounds |
| D. | Nitrite compounds |
| Answer» D. Nitrite compounds | |
| 95. |
What does the hydrolysis of Aspirin yield us with? |
| A. | Salicylic acid only |
| B. | Salicylic acid and CH3COOH |
| C. | CH3COOH |
| D. | Succinic acid |
| Answer» B. Salicylic acid and CH3COOH | |
| 96. |
Which enzyme is important in the Phase II reactions? |
| A. | Esterase |
| B. | Amidases |
| C. | Transferase |
| D. | Aldo-keto-reductases |
| Answer» C. Transferase | |
| 97. |
Which of the following groups is least susceptible to cytochrome P450 enzymes? |
| A. | Terminal methyl groups |
| B. | Epoxide group |
| C. | Benzylic carbon atoms |
| D. | Quaternary carbon atoms |
| Answer» D. Quaternary carbon atoms | |
| 98. |
Alkenes and aromatic groups can be metabolised to diols. Which enzymes are involved? |
| A. | cytochrome P450 enzymes |
| B. | epoxide hydrolase |
| C. | both of the above |
| D. | neither of the above |
| Answer» C. both of the above | |
| 99. |
Solubility of a drug in polar solvents and Non-polar solvents depends upon |
| A. | Chemical structure |
| B. | Particle size |
| C. | Crystal form |
| D. | All of above |
| Answer» D. All of above | |
| 100. |
Higher will be the diffusion of the drug across the membrane if |
| A. | Higher value of partition-coefficient |
| B. | Low value of partition-coefficient |
| C. | Higher water soluble |
| D. | None of above |
| Answer» A. Higher value of partition-coefficient | |
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