McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
| 1. |
Oral controlled release drugs release the drug only inside the intestine. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 2. |
What are the characteristics of continuous release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Prolonged their residence in the GIT and release |
| C. | Release only at a specific drug |
| D. | Release as soon as comes in contact to the saliva |
| Answer» B. Prolonged their residence in the GIT and release | |
| 3. |
What is the characteristic of delayed transit and continuous release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Prolonged their residence in the GIT and release |
| C. | Release only at a specific drug |
| D. | Release as soon as comes in contact to the saliva |
| Answer» B. Prolonged their residence in the GIT and release | |
| 4. |
What is the characteristic of delayed release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Prolonged their residence in the GIT and release |
| C. | Release only at a specific drug |
| D. | Release as soon as comes in contact to the saliva |
| Answer» C. Release only at a specific drug | |
| 5. |
What is the characteristic of dissolution controlled release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Prolonged their residence in the GIT and release |
| C. | Release only at a specific drug |
| D. | Very slow dissolution rate |
| Answer» D. Very slow dissolution rate | |
| 6. |
What is the characteristic of matrix dissolution-controlled release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Prolonged their residence in the GIT and release |
| C. | Release only at a specific drug |
| D. | Employ waxes to control the rate of dissolution |
| Answer» D. Employ waxes to control the rate of dissolution | |
| 7. |
What is the characteristic of encapsulation or coating dissolution-controlled release systems? |
| A. | Microencapsulation using slowly dissolving materials |
| B. | Prolonged their residence in the GIT and release |
| C. | Release only at a specific drug |
| D. | Employ waxes to control the rate of dissolution |
| Answer» A. Microencapsulation using slowly dissolving materials | |
| 8. |
What are the characteristics of diffusion-controlled release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Diffusion of the dissolved drug |
| C. | Release only at a specific drug |
| D. | Employ waxes to control the rate of dissolution |
| Answer» B. Diffusion of the dissolved drug | |
| 9. |
What are the characteristics of Matrix diffusion-controlled release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Drug disperse in an insoluble matrix of rigid hydrophobic materials |
| C. | Release only at a specific drug |
| D. | Employ waxes to control the rate of dissolution |
| Answer» B. Drug disperse in an insoluble matrix of rigid hydrophobic materials | |
| 10. |
What are the characteristics of reservoir devices-controlled release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Drug disperse in the insoluble matrix of rigid hydrophobic materials |
| C. | Hollow systems containing drug surrounded by a polymer membrane |
| D. | Employ waxes to control the rate of dissolution |
| Answer» C. Hollow systems containing drug surrounded by a polymer membrane | |
| 11. |
What are the characteristics of ion exchange resin drug complexes? |
| A. | Release the drug along the entire length of GIT |
| B. | Drug disperse in an insoluble matrix of rigid hydrophobic materials |
| C. | Hollow systems containing drug surrounded by a polymer membrane |
| D. | Formation of complexes between the drug and anion/cation exchange resins |
| Answer» D. Formation of complexes between the drug and anion/cation exchange resins | |
| 12. |
What is the characteristic of pH-independent formulations? |
| A. | Buffering agents that adjust pH to the desired value |
| B. | Drug disperse in the insoluble matrix of rigid hydrophobic materials |
| C. | Hollow systems containing drug surrounded by a polymer membrane |
| D. | Formation of complexes between the drug and anion/cation exchange resins |
| Answer» A. Buffering agents that adjust pH to the desired value | |
| 13. |
What are the characteristics of osmotic pressure-controlled systems? |
| A. | Buffering agents that adjust pH to the desired value |
| B. | Releases the drug at a zero-order kinetics |
| C. | Hollow systems containing drug surrounded by a polymer membrane |
| D. | Formation of complexes between the drug and anion/cation exchange resins |
| Answer» B. Releases the drug at a zero-order kinetics | |
| 14. |
Osmotic pressure controlled systems work on the principle of osmotic pressure releasing the drug at constant 1st order kinetics. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 15. |
What are the characteristics of hydrodynamic pressure controlled systems? |
| A. | Buffering agents that adjust pH to the desired value |
| B. | Drug disperse in an insoluble matrix of rigid hydrophobic materials |
| C. | Generated by swelling hydrophilic hum |
| D. | Formation of complexes between the drug and anion/cation exchange resins |
| Answer» C. Generated by swelling hydrophilic hum | |
| 16. |
What is the characteristics of altered density systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Prolonged their residence in the GIT and release |
| C. | Release only at a specific drug |
| D. | Use of high or low density pellets |
| Answer» D. Use of high or low density pellets | |
| 17. |
What is the characteristics of floating or buoyant capsule systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Granule drug with hydro gel |
| C. | Release only at a specific drug |
| D. | Use of high or low density pellets |
| Answer» B. Granule drug with hydro gel | |
| 18. |
What is the characteristics of mucoadhesive systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Prolonged their residence in the GIT and release |
| C. | Usage of bio adhesive polymer |
| D. | Use of high or low density pellets |
| Answer» C. Usage of bio adhesive polymer | |
| 19. |
Enteric coating are used for which systems? |
| A. | Intestinal release systems |
| B. | Colonic release systems |
| C. | Size based systems |
| D. | Mucoadhesive systems |
| Answer» A. Intestinal release systems | |
| 20. |
Drugs cannot be delivered to the colon. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 21. |
What is the characteristics of intestinal release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Prolonged their residence in the GIT and release |
| C. | Usage of polymers that dissolves only in the alkaline pH of colon |
| D. | Use of enteric coating |
| Answer» D. Use of enteric coating | |
| 22. |
What is the characteristics of colonic release systems? |
| A. | Release the drug along the entire length of GIT |
| B. | Prolonged their residence in the GIT and release |
| C. | Usage of polymers that dissolves only in the alkaline pH of colon |
| D. | Use of enteric coating |
| Answer» C. Usage of polymers that dissolves only in the alkaline pH of colon | |
| 23. |
Liposomes are spherical structures, usually between in diameter: |
| A. | 80nm-100nm |
| B. | 60nm-100nm |
| C. | 55nm-1000nm |
| D. | 15nm-1000nm |
| Answer» D. 15nm-1000nm | |
| 24. |
Liposomes consists of a bilayer of |
| A. | Hydrophilic molecules |
| B. | Hydrophobic molecules |
| C. | Both a and b |
| D. | None |
| Answer» C. Both a and b | |
| 25. |
Liposomes have half life |
| A. | Longer |
| B. | Shorter |
| C. | Intermediate |
| D. | Both a and b |
| Answer» B. Shorter | |
| 26. |
Liposomes have solubility |
| A. | Lower |
| B. | Higher |
| C. | Both a and b |
| D. | None |
| Answer» A. Lower | |
| 27. |
Liposome phospholipids undergoes |
| A. | Oxidation |
| B. | Hydrolysis |
| C. | Acetylation |
| D. | Both a and b |
| Answer» D. Both a and b | |
| 28. |
The diameter of Small unilamellar vesicles is |
| A. | 20-100nm |
| B. | 20-1000nm |
| C. | 10-100nm |
| D. | 100nm-400nm |
| Answer» A. 20-100nm | |
| 29. |
Intermediate sized unilamellar vesicles are prepared by |
| A. | Sonication |
| B. | High pressure extrusion technique |
| C. | Detergent dialysis |
| D. | Both b and c |
| Answer» D. Both b and c | |
| 30. |
Tranfersome belongs to the classification according to |
| A. | Composition |
| B. | Application |
| C. | Function |
| D. | None of the above |
| Answer» C. Function | |
| 31. |
Liposomes with ___________number of lamella are called as “pauci -lamellar liposomes” |
| A. | Lower |
| B. | Higher |
| C. | Single |
| D. | None of the above |
| Answer» A. Lower | |
| 32. |
Loading of the entrapped agents before/during the manufacture procedure is known as |
| A. | Active loading |
| B. | Passive loading |
| C. | Both a and b |
| D. | None of the above |
| Answer» B. Passive loading | |
| 33. |
Passive Loading Technique includes |
| A. | Lyophilization |
| B. | Proliposomes |
| C. | Solvent dispersion |
| D. | Both a and b |
| Answer» C. Solvent dispersion | |
| 34. |
Drawback of Lipid hydration method is |
| A. | Low internal volume |
| B. | High encapsulation efficiency |
| C. | Size distribution is homogenous |
| D. | None of the above |
| Answer» A. Low internal volume | |
| 35. |
Tip of sonicator is directly engrossed into liposome dispersion in |
| A. | Bath sonication |
| B. | Probe sonication |
| C. | None of the above |
| D. | all |
| Answer» B. Probe sonication | |
| 36. |
The resulting liposomes from French pressure cell extrusion are ______than sonicated SUVs |
| A. | Smaller |
| B. | Equal |
| C. | Larger |
| D. | all |
| Answer» C. Larger | |
| 37. |
To produce a microemulsion of small vesicles at least _______ circulations are required |
| A. | at least 20 circulation but not greater than 200 |
| B. | 10 circulations |
| C. | at least 200 circulation but not greater than 2000 |
| D. | at least 2 circulations but not greater than 10 |
| Answer» A. at least 20 circulation but not greater than 200 | |
| 38. |
Dried reconstituted vesicles method is performed in |
| A. | Solvent dispersion |
| B. | Mechanical dispersion |
| C. | Both a and b |
| D. | none |
| Answer» B. Mechanical dispersion | |
| 39. |
Solvent vaporization is also known as |
| A. | Ether injection |
| B. | Ethanol injection |
| C. | Double emulsification |
| D. | Reverse-phase evaporation |
| Answer» A. Ether injection | |
| 40. |
Amphotericin B liposomes are given |
| A. | Lungs |
| B. | Oral |
| C. | Transdermal |
| D. | Intravenous |
| Answer» B. Oral | |
| 41. |
Ketoconazole liposomes are given by |
| A. | Lungs |
| B. | Oral |
| C. | Transdermal |
| D. | Intravenous |
| Answer» C. Transdermal | |
| 42. |
Temperature used for Ether Injection method is______ or under reduced pressure |
| A. | 15-25 0C |
| B. | 55-65 0C |
| C. | 55-85 0C |
| D. | None of the above |
| Answer» B. 55-65 0C | |
| 43. |
Which of the following drugs cannot be given as transdermal administration? |
| A. | Drugs with very short half-lives |
| B. | Drugs with narrow therapeutic indices |
| C. | Easy removal and termination |
| D. | Drugs against peptic ulcer |
| Answer» D. Drugs against peptic ulcer | |
| 44. |
Which of the following characteristics is suitable for transdermal drug? |
| A. | Large drug dose |
| B. | Large molecular size |
| C. | Drugs with narrow therapeutic indices |
| D. | Drugs which are metabolized in the skin |
| Answer» C. Drugs with narrow therapeutic indices | |
| 45. |
What are the characteristics of the monolithic devices? |
| A. | The drug has a large therapeutic index |
| B. | Aqueous solutions |
| C. | Control drug release by partitioning the drug from the oil |
| D. | Administration of emulsions |
| Answer» A. The drug has a large therapeutic index | |
| 46. |
The rate at which monolithic devices transfer drugs to the patient body is proportional to _______________ of time |
| A. | Square of time |
| B. | The square root of time |
| C. | Twice the time |
| D. | Half the time |
| Answer» B. The square root of time | |
| 47. |
What are the characteristics of the reservoir or membrane devices? |
| A. | The drug has a large therapeutic index |
| B. | Drug permeation rate is high |
| C. | Control drug release by partitioning the drug from the oil |
| D. | Administration of emulsions |
| Answer» B. Drug permeation rate is high | |
| 48. |
What are the characteristics of the mixed monolithic-reservoir devices? |
| A. | The drug has a large therapeutic index |
| B. | Drug permeation rate is high |
| C. | The drug-polymer matrix is layered by rate-controlling membrane |
| D. | Administration of emulsions |
| Answer» C. The drug-polymer matrix is layered by rate-controlling membrane | |
| 49. |
The absorption of the ophthalmic drug does not depend on which of the following? |
| A. | Physicochemical properties of the permeating molecule |
| B. | Drainage of tears |
| C. | Output of tears |
| D. | Size of the eyeball |
| Answer» D. Size of the eyeball | |
| 50. |
Which of the following is false in regarding reservoir devices? |
| A. | These devices are used when the drug permeation rate is rapid |
| B. | The release of the drug is controlled |
| C. | Suitable for low therapeutic indices |
| D. | The drug is contained in a powder form floating on liquid |
| Answer» D. The drug is contained in a powder form floating on liquid | |
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