McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
| 101. |
In two compartment model, extravascular route of drug administration, there are ……phases |
| A. | absorption phase, |
| B. | Distribution phase |
| C. | elimination phase, |
| D. | All of the above |
| Answer» D. All of the above | |
| 102. |
Ka is estimated by |
| A. | Method of Residuals |
| B. | Loo Riegelman method |
| C. | Both a and b |
| D. | None of the above |
| Answer» C. Both a and b | |
| 103. |
The central compartment consist of |
| A. | Highly perfused tissues |
| B. | Slowly equilibrate tissues |
| C. | Both a and b |
| D. | Reproductive org |
| Answer» A. Highly perfused tissues | |
| 104. |
What does "pharmacokinetics" includes? |
| A. | Mechanisms of drug action |
| B. | Localization of drug action |
| C. | Interaction of substances |
| D. | Excretion of substances |
| Answer» D. Excretion of substances | |
| 105. |
Pharmacokinetics is: |
| A. | The study of absorption, distribution, metabolism and excretion of drugs |
| B. | The study of biological and therapeutic effects of drugs |
| C. | The study of methods of new drug development |
| D. | The study of mechanisms of drug action |
| Answer» A. The study of absorption, distribution, metabolism and excretion of drugs | |
| 106. |
What does "pharmacokinetics" includes? |
| A. | Drug biotransformation in the organism |
| B. | Influence of drugs on metabolism processes |
| C. | Influence of drugs on genes |
| D. | Complications of drug therapy |
| Answer» A. Drug biotransformation in the organism | |
| 107. |
Parenteral administration: |
| A. | Is too slow for emergency use |
| B. | Cannot be used with unconsciousness patients |
| C. | Generally results in a less accurate dosage than oral administration |
| D. | Usually produces a more rapid response than oral administration |
| Answer» D. Usually produces a more rapid response than oral administration | |
| 108. |
The volume of distribution (Vd) relates: |
| A. | The amount of a drug in the body to the concentration of a drug in plasma |
| B. | An uncharged drug reaching the systemic circulation |
| C. | Single to a daily dose of an administrated drug |
| D. | An administrated dose to a body weight |
| Answer» A. The amount of a drug in the body to the concentration of a drug in plasma | |
| 109. |
For the calculation of the volume of distribution (Vd) one must take into account: |
| A. | Concentration of substance in urine |
| B. | Therapeutical width of drug action |
| C. | A daily dose of drug |
| D. | Concentration of a substance in plasma |
| Answer» D. Concentration of a substance in plasma | |
| 110. |
……….. is a mathematical concept which describes a space in the body which a drug appears to occupy. |
| A. | Order of reaction |
| B. | Compartment |
| C. | Distribution |
| D. | Elimination |
| Answer» B. Compartment | |
| 111. |
………………..is the manner in which a drug is taken. |
| A. | Dosage regimen |
| B. | Dosage volume |
| C. | Dosage loading |
| D. | None of the above |
| Answer» A. Dosage regimen | |
| 112. |
…………………it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R. |
| A. | Accumulation Index |
| B. | Apparent volume of drug distribution |
| C. | Accumulation factor |
| D. | None of the above |
| Answer» A. Accumulation Index | |
| 113. |
………………… is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. |
| A. | Primary Dose |
| B. | Initial Dose |
| C. | Loading dose |
| D. | None of the above |
| Answer» C. Loading dose | |
| 114. |
The compartment models provide visual representation of various rate processes involved in drug disposition. Given statement is: |
| A. | False |
| B. | True |
| C. | Cannot say |
| D. | None of the above |
| Answer» B. True | |
| 115. |
...................is composed of highly perfused tissues, extracellular fluid, and blood with rapid and uniform drug distribution. |
| A. | Central compartment |
| B. | Peripheral compartment |
| C. | both of the above |
| D. | None of the above |
| Answer» A. Central compartment | |
| 116. |
……………composed of groups of tissues with lower blood perfusion and different affinity the drug with slow drug distribution. |
| A. | Central compartment |
| B. | Peripheral compartment |
| C. | Both of the above |
| D. | None of the above |
| Answer» B. Peripheral compartment | |
| 117. |
A multicompartment model assumes that all transfer rate processes for the passage of drug into or out of individual compartments are…………….. processes. |
| A. | First-order |
| B. | Second order |
| C. | Pseudo order |
| D. | None of the above |
| Answer» A. First-order | |
| 118. |
The multicompartment models are intended to provide……………. |
| A. | Therapeutic activity of the drug |
| B. | Achieve maximum efficacy |
| C. | Both of the above |
| D. | None of the above |
| Answer» C. Both of the above | |
| 119. |
The biological half-life of drug: |
| A. | is a constant physical property of the drug |
| B. | is a constant chemical property of the drug |
| C. | may be increased in patients with impaired renal failure |
| D. | may be decreased in patients by giving the drug by rapid I.V. injection |
| Answer» C. may be increased in patients with impaired renal failure | |
| 120. |
The half life of a drug eliminated by first order elimination kinetics will be longer in individuals who have an: |
| A. | increased volume of distribution or increased clearance |
| B. | increased volume of distribution or decreased clearance |
| C. | decreased volume of distribution or increased clearance |
| D. | decreased volume of distribution or decreased clearance |
| Answer» B. increased volume of distribution or decreased clearance | |
| 121. |
Half life (t1/2) is the time required to: |
| A. | change the amount of a drug in plasma by half during elimination |
| B. | metabolize a half of an introduced drug into the active metabolite |
| C. | absorb a half of an introduced drug |
| D. | bind a half of an introduced drug to plasma proteins |
| Answer» A. change the amount of a drug in plasma by half during elimination | |
| 122. |
Half life (t1/2) does not depend on: |
| A. | biotransformation |
| B. | time of drug absorption |
| C. | concentration of a drug in plasma |
| D. | rate of drug elimination |
| Answer» B. time of drug absorption | |
| 123. |
Elimination rate constant (Kelim) is defined by the following parameter: |
| A. | rate of absorption |
| B. | maximal concentration of a substance in plasma |
| C. | highest single dose |
| D. | half life (t1/2) |
| Answer» D. half life (t1/2) | |
| 124. |
Systemic clearance (Cl) is related with: |
| A. | only the concentration of substances in plasma |
| B. | only the elimination rate constant |
| C. | volume of distribution, half life and elimination rate constant |
| D. | bioavailability and half life |
| Answer» C. volume of distribution, half life and elimination rate constant | |
| 125. |
Biological Half life equation for first order process is |
| A. | t1/2 = a/2K |
| B. | t1/2 = 0.693/K |
| C. | t1/2 = 1/aK |
| D. | t1/2 = 3/2 K |
| Answer» B. t1/2 = 0.693/K | |
| 126. |
The area under the serum concentration time curve of the drug represents: |
| A. | the biological half life of the drug |
| B. | the amount of drug in the original dosage form |
| C. | The amount of drug absorbed |
| D. | The amount of drug excreted in the urine |
| Answer» C. The amount of drug absorbed | |
| 127. |
Drug having ……..half-lives take a very short time to achieve plateau concentration. |
| A. | shorter |
| B. | longer |
| C. | intermediate |
| D. | none of the above |
| Answer» A. shorter | |
| 128. |
The primary pharmacokinetic parameter clearance can be calculated by |
| A. | Cl = KV |
| B. | Cl = Dose/AUC |
| C. | Cl = (dA/dt)/C |
| D. | all of the above |
| Answer» D. all of the above | |
| 129. |
………..change in drug kinetics is known as chronokinetics. |
| A. | Time-dependent |
| B. | Dose-dependent |
| C. | Both (a) & (b) |
| D. | None of the above |
| Answer» A. Time-dependent | |
| 130. |
Constant rate infusion prevents………..in blood levels. |
| A. | fluctuations |
| B. | peak maximum |
| C. | valley minimum |
| D. | all of the above |
| Answer» D. all of the above | |
| 131. |
Constant rate infusion is…….. |
| A. | prevents fluctuations |
| B. | useful when drug has narrow TI |
| C. | Both (a) & (b) |
| D. | none of the above |
| Answer» C. Both (a) & (b) | |
| 132. |
Concentration of drug at peak is known as …………drug concentration. |
| A. | maximum |
| B. | minimum |
| C. | lower |
| D. | none of the above |
| Answer» A. maximum | |
| 133. |
In one compartment open model, the term open indicates input and output is: |
| A. | unidirectional |
| B. | bidirectional |
| C. | non-directional |
| D. | none of the above |
| Answer» A. unidirectional | |
| 134. |
The mathematical relationship between plasma drug concentration and pharmacological response is called as……….. |
| A. | PK modeling |
| B. | PD modeling |
| C. | PK-PD modeling |
| D. | None of the above |
| Answer» C. PK-PD modeling | |
| 135. |
The ratio of maximum safe concentration to minimum effective concentration is called as |
| A. | Therapeutic index |
| B. | Therapeutic range |
| C. | Therapeutic outcome |
| D. | Therapeutic ratio |
| Answer» A. Therapeutic index | |
| 136. |
Half life of zero-order process is proportional to of drug. |
| A. | initial concentration |
| B. | final concentration |
| C. | both (a) & (b) |
| D. | none of the above |
| Answer» A. initial concentration | |
| 137. |
The ability of liver to excrete drug in bile is expressed by……… |
| A. | hepatic clearance |
| B. | biliary clearance |
| C. | non-renal clearance |
| D. | renal clearance |
| Answer» B. biliary clearance | |
| 138. |
………… is nothing but manner in which drug should be taken. |
| A. | dosing frequency |
| B. | dosage regimen |
| C. | dose adjustment |
| D. | none of the above |
| Answer» B. dosage regimen | |
| 139. |
What is dosage regimen? |
| A. | The concentration of active agent in the drug formulation |
| B. | The manner in which the drug is given to old people |
| C. | The manner in which a drug is taken |
| D. | The manner in which drug given to child |
| Answer» C. The manner in which a drug is taken | |
| 140. |
What is optimal multiple dosage regimen? |
| A. | The concentration of active agent in the drug formulation |
| B. | Dosage which maintains the plasma concentration within the therapeutic window. |
| C. | The manner in which a drug is taken |
| D. | The manner in which drug given to child |
| Answer» B. Dosage which maintains the plasma concentration within the therapeutic window. | |
| 141. |
On what basis the dose interval is calculated? |
| A. | Active drug concentration in the formulation |
| B. | Half-life of the drug |
| C. | Duration of the disease |
| D. | Age of the patient |
| Answer» B. Half-life of the drug | |
| 142. |
What is fluctuation? |
| A. | Cmax/Cmin |
| B. | Cmin / Cmax |
| C. | 1/Cmin |
| D. | 1/Cmax |
| Answer» A. Cmax/Cmin | |
| 143. |
How do you calculate the ideal body weight for men? |
| A. | 50 kg +- 1kg/2.5cm above or below 150 cm in height |
| B. | 45 kg +- 1kg/2.5cm above or below 150 cm in height |
| C. | 40 kg +- 1kg/2.5cm above or below 150 cm in height |
| D. | 35 kg +- 1kg/2.5cm above or below 150 cm in height |
| Answer» A. 50 kg +- 1kg/2.5cm above or below 150 cm in height | |
| 144. |
How do you calculate the ideal body weight for a woman? |
| A. | 50 kg +- 1kg/2.5cm above or below 150 cm in height |
| B. | 45 kg +- 1kg/2.5cm above or below 150 cm in height |
| C. | 40 kg +- 1kg/2.5cm above or below 150 cm in height |
| D. | 35 kg +- 1kg/2.5cm above or below 150 cm in height |
| Answer» B. 45 kg +- 1kg/2.5cm above or below 150 cm in height | |
| 145. |
Which of the following drugs are lipid soluble? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» A. Phenytoin | |
| 146. |
Which of the following drugs get distributed to the same extent in both lean and adipose tissue? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» B. Caffeine | |
| 147. |
Which of the following drugs can get distributed to the excess body space of obese patient? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» D. Antibiotics | |
| 148. |
Which of the following drug can get distributed in the excess body space? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» C. Digoxin | |
| 149. |
Neonates, infants and children require different dosages than adults. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 150. |
Accumulation occurs because drug from previous doses was not being removed completely. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
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