McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
| 51. |
Which of the following is true for monolithic devices? |
| A. | These devices are used when the drug permeation rate is rapid |
| B. | The release of the drug is controlled |
| C. | Suitable for drugs with large therapeutic indices |
| D. | The drug is contained in a powder form floating on liquid |
| Answer» C. Suitable for drugs with large therapeutic indices | |
| 52. |
The duration of action of parental controlled release systems can be extended up to what time? |
| A. | 1 day |
| B. | 1 week |
| C. | 1 month |
| D. | Day, week, month even a year |
| Answer» D. Day, week, month even a year | |
| 53. |
What is the drawback of parental controlled release systems? |
| A. | Injecting is a difficulty |
| B. | The drug cannot be easily removed once administered |
| C. | Can get easily precipitated in the injection site |
| D. | Rapid onset but fast excretion |
| Answer» B. The drug cannot be easily removed once administered | |
| 54. |
Which one of the following should not be a characteristic of the vehicles or polymers which are used for parenteral formulations? |
| A. | Sterile |
| B. | Consists of pyrogen |
| C. | Nonirritating |
| D. | Biodegradable |
| Answer» B. Consists of pyrogen | |
| 55. |
With aqueous solutions, the drug releases can be controlled. Which of the following is not the right method of controlling? |
| A. | Increasing the viscosity |
| B. | By forming complexes with macromolecules |
| C. | Reducing the solubility of the parent drug |
| D. | Increasing the pH to make it highly basic |
| Answer» D. Increasing the pH to make it highly basic | |
| 56. |
Release of water-soluble drugs can be retarded by presenting it as ____________ suspension |
| A. | Oil |
| B. | Water |
| C. | Colloidal |
| D. | Freezing |
| Answer» A. Oil | |
| 57. |
Larger particle size leads to ____________ dissolution |
| A. | Slower |
| B. | Faster |
| C. | Moderate |
| D. | Normal |
| Answer» A. Slower | |
| 58. |
Which of the following is a characteristic of microspheres? |
| A. | Free flowing powders |
| B. | Aqueous solutions |
| C. | Control drug release by partitioning the drug from the oil |
| D. | Administration of emulsions |
| Answer» A. Free flowing powders | |
| 59. |
Which of the following is a characteristic of oil solutions? |
| A. | Free flowing powders |
| B. | Aqueous solutions |
| C. | Control drug release by partitioning the drug from the oil |
| D. | Administration of emulsions |
| Answer» C. Control drug release by partitioning the drug from the oil | |
| 60. |
Which of the following is a characteristic of aqueous solutions? |
| A. | Free flowing powders |
| B. | Drug release can be increased by increasing viscosity |
| C. | Control drug release by partitioning the drug from the oil |
| D. | Administration of emulsions |
| Answer» B. Drug release can be increased by increasing viscosity | |
| 61. |
Which of the following is a characteristic of nanoparticles? |
| A. | Free flowing powders |
| B. | Aqueous solutions |
| C. | Control drug release by partitioning the drug from the oil |
| D. | Size range 10-100 nm |
| Answer» D. Size range 10-100 nm | |
| 62. |
Which of the following is a characteristic of the parental controlled drug release system by liposomes? |
| A. | Free flowing powders |
| B. | Aqueous solutions |
| C. | Lipid bilayer enclosing the drug |
| D. | Administration of emulsions |
| Answer» C. Lipid bilayer enclosing the drug | |
| 63. |
Which of the following can be incorporated into a liposome? |
| A. | Only drugs and viruses |
| B. | Only Peptides and viruses due to similar characteristics |
| C. | Only viruses |
| D. | Drugs, peptides, viruses, bacteria |
| Answer» D. Drugs, peptides, viruses, bacteria | |
| 64. |
Which of the following is a characteristic of resealed erythrocytes? |
| A. | Nonimmunogenic |
| B. | Aqueous solutions |
| C. | Control drug release by partitioning the drug from the oil |
| D. | Size range 10-100 nm |
| Answer» A. Nonimmunogenic | |
| 65. |
Which of the following statement is false for osmotic pumps? |
| A. | The pump has three concentric circle |
| B. | The innermost is the drug reservoir |
| C. | The drug is contained a permeable polyester bag |
| D. | Outer most rigid rate controlling semipermeable membrane |
| Answer» C. The drug is contained a permeable polyester bag | |
| 66. |
Which of the following statement is true for osmotic pumps? |
| A. | The tube is made up of stainless steel |
| B. | The innermost is the drug reservoir in a no collapsible bag |
| C. | The drug is contained a permeable polyester bag |
| D. | The outer most cover is soft and easily permeable |
| Answer» A. The tube is made up of stainless steel | |
| 67. |
Which of the following should not be a property of implants? |
| A. | Environmental stable |
| B. | Biostable |
| C. | Non-toxic |
| D. | Nonremovable |
| Answer» D. Nonremovable | |
| 68. |
Which is the disadvantage for implants? |
| A. | More effective |
| B. | More prolonged action |
| C. | Significantly small dose |
| D. | Need of microsurgery |
| Answer» D. Need of microsurgery | |
| 69. |
Subcutaneous tissue is an ideal location for implants? |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 70. |
Which of the following drugs are used in implants? |
| A. | Pantoprazole |
| B. | Mannitol |
| C. | Amlodipine |
| D. | Morphine antagonist |
| Answer» D. Morphine antagonist | |
| 71. |
Which of the following is a false statement for vapour pressure pump? |
| A. | The device consists of two chambers |
| B. | A chamber contains the drug solution |
| C. | Drug solution chamber is separated by rigid walls |
| D. | Vapour chamber contains vaporizable fluids |
| Answer» C. Drug solution chamber is separated by rigid walls | |
| 72. |
After implantation of a vapour pressure pump, the body has to get heated by exercising so that the volatile liquid vaporizes. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 73. |
Which of the following is a characteristic of battery powered pumps? |
| A. | Free flowing powders |
| B. | The system is programmed to release drugs at a controlled rate |
| C. | Control drug release by partitioning the drug from the oil |
| D. | Administration of emulsions |
| Answer» B. The system is programmed to release drugs at a controlled rate | |
| 74. |
The drug loading in resealed erythrocytes can be done by 1st immersing the cells in a buffered hypertonic solution. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 75. |
How are MLV liposomes made? |
| A. | 2-10 bilayers of lipid |
| B. | Series of concentric bilayers of lipid |
| C. | The single bilayer of lipid |
| D. | 100 bilayer of lipid |
| Answer» B. Series of concentric bilayers of lipid | |
| 76. |
How are OLV liposomes made? |
| A. | 2-10 bilayers of lipid |
| B. | Series of concentric bilayers of lipid |
| C. | A single bilayer of lipid |
| D. | 100 bilayer of lipid |
| Answer» A. 2-10 bilayers of lipid | |
| 77. |
The concentration of drug in plasma above which toxic effects are precipitated is known as |
| A. | Maximum safe concentration |
| B. | Minimum Effective Concentration |
| C. | Intensity of Action |
| D. | Duration of Action |
| Answer» A. Maximum safe concentration | |
| 78. |
When rate is independent of the reactant concentration, then it is called |
| A. | zero order reaction |
| B. | Pseudo zero order reaction |
| C. | First order reaction |
| D. | Second order reaction |
| Answer» A. zero order reaction | |
| 79. |
Which of the following is the half life of zero order reaction? |
| A. | t1/2 = A0 /2k |
| B. | t1/2 = 0.693/2k |
| C. | t1/2 = A0 /2 |
| D. | t1/2 = 2k/ A0 |
| Answer» A. t1/2 = A0 /2k | |
| 80. |
The unit of k for zero order reaction is |
| A. | moles/litre/second |
| B. | moles |
| C. | moles/second |
| D. | moles/litre |
| Answer» A. moles/litre/second | |
| 81. |
Which of the following is the half life of first order reaction? |
| A. | t1/2 = A0 / 2k |
| B. | t1/2 = 0.693 / 2k |
| C. | tl/2 = 2k |
| D. | tl/2 = 0.693 / k |
| Answer» D. tl/2 = 0.693 / k | |
| 82. |
Which of the following is not a pharmacokinetic parameters that describe the plasma level time curve? |
| A. | tmax |
| B. | cmax |
| C. | Area under Curve |
| D. | Minimum Effective Concentration |
| Answer» D. Minimum Effective Concentration | |
| 83. |
The drug concentration between Minimum Effective Concentration and Maximum Safe Concentration is called |
| A. | Therapeutic range |
| B. | Area under curve |
| C. | Peak response |
| D. | Pharmacological response |
| Answer» A. Therapeutic range | |
| 84. |
tmax indicates |
| A. | drug absorption rate |
| B. | drug elimination rate |
| C. | drug distribution rate |
| D. | drug metabolism rate |
| Answer» A. drug absorption rate | |
| 85. |
What Will be the approximate Tmax of a drug exhibiting Ka of 2 hr-1 and K of 0.2 hr-1 ? |
| A. | 1.2 hr |
| B. | 2.4 hr |
| C. | 4.8 hr |
| D. | 2.0 hr |
| Answer» A. 1.2 hr | |
| 86. |
A drug solution has half life of 21 days. Assuming that drug undergoes first order kinetics, how long will it take for the potency to drop to 90% of initial potency? |
| A. | 3.2 days |
| B. | 9.6 days |
| C. | 16 days |
| D. | 6.2 days |
| Answer» A. 3.2 days | |
| 87. |
A suspension shows zero-order kinetic with a rate constant 2mg/ml.month. The dose of suspension is 20mg/ml. The biological half life of the above dosage form is |
| A. | 5 months |
| B. | 1 month |
| C. | 3 months |
| D. | 2 months |
| Answer» A. 5 months | |
| 88. |
Drug showing zero order kinetic of elimination |
| A. | Are more common than those showing first order kinetic |
| B. | Show plot of drug concentration vs time (linear Plot) |
| C. | Decrease in concentration exponentially with time |
| D. | Have half life independent of dose |
| Answer» B. Show plot of drug concentration vs time (linear Plot) | |
| 89. |
Elimination after 4 half lives in first order kinetics is |
| A. | 84% |
| B. | 93% |
| C. | 80% |
| D. | 4% |
| Answer» B. 93% | |
| 90. |
Which one is irrational statement for first order kinetics? |
| A. | Half life is a function of concentration of reactants |
| B. | Reaction rate is not a function of concentration of reactants |
| C. | Both a & b |
| D. | All of these |
| Answer» D. All of these | |
| 91. |
T % (Half life time) of a drug can determine all of the following except |
| A. | Closing interval |
| B. | Therapeutic dose |
| C. | Elimination time |
| D. | Steady plasma concentration |
| Answer» B. Therapeutic dose | |
| 92. |
The area under serum concentration time curve of drug represents |
| A. | The biological half life of the drug |
| B. | Amount of drug biotransformed |
| C. | The amount of drug absorbed |
| D. | The amount of drug excreted in urine |
| Answer» D. The amount of drug excreted in urine | |
| 93. |
Under non compartment analysis the following formula is used for calculation |
| A. | MRT = AUMC / AUC |
| B. | AUMC = MRT / AUC |
| C. | MRT = AUC / AUMC |
| D. | AUC = AUMC / MRT |
| Answer» A. MRT = AUMC / AUC | |
| 94. |
Under compartment modeling, Wegner-Nelson-Method involves |
| A. | Determination of absorption rate constant (Ka) from %ARA Vs time curve |
| B. | Determination of elimination rate constant (Ka) from % ARA Vs time curve |
| C. | Determination of absorption rate constant (Ke) from %ARA •Vs Concentration curve |
| D. | Determination of plasma half life |
| Answer» A. Determination of absorption rate constant (Ka) from %ARA Vs time curve | |
| 95. |
The steady-state concentration of a drug can be double by: |
| A. | Doubling the both rate of infusion and concentration of drug. |
| B. | Doubling the rate of infusion only. |
| C. | Doubling the loading dose but maintaining the infusion rate. |
| D. | Tripling the rate of infusion. |
| Answer» B. Doubling the rate of infusion only. | |
| 96. |
In compartment modeling the term "Open" indicates |
| A. | Unidirectional input and output |
| B. | All compartments are open |
| C. | Body is open |
| D. | None of the above |
| Answer» A. Unidirectional input and output | |
| 97. |
Select the formula to calculate steady state concentration follows IV infusion |
| A. | Css= Infusion Rate/ Clearance |
| B. | Css= Clearance / Infusion Rate |
| C. | Css= Infusion Rate X Clearance |
| D. | Css = Infusion Rate - Clearance |
| Answer» A. Css= Infusion Rate/ Clearance | |
| 98. |
IV infusion model follows |
| A. | Zero order absorption and first order elimination kinetic |
| B. | No absorption and first order elimination kinetic |
| C. | No absorption and Zero order elimination kinetic |
| D. | First order absorption and first order elimination kinetic |
| Answer» A. Zero order absorption and first order elimination kinetic | |
| 99. |
Select the formula to calculate elimination half life |
| A. | t1/2 = 0.693 + Ke |
| B. | t1/2 = 0.693 / Ke |
| C. | t1/2 = 0.693 × Ke |
| D. | t1/2 = 0.693 – Ke |
| Answer» B. t1/2 = 0.693 / Ke | |
| 100. |
The constants that represent reversible transfer of drug between compartments are called as |
| A. | microconstants |
| B. | macroconstant |
| C. | Infusion |
| D. | Lag time |
| Answer» A. microconstants | |
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