McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
| 151. |
The renal clearance of a drug bound to plasma protein is increased after displacement with another drug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 152. |
Which of the following promotes excretion of acidic drugs? |
| A. | Citrates |
| B. | Ammonium chloride |
| C. | Methionine |
| D. | Ascorbic acid |
| Answer» A. Citrates | |
| 153. |
Which of the following promotes the excretion of basic drugs? |
| A. | Tartarates |
| B. | Citrates |
| C. | Bicarbonates |
| D. | Ammonium chloride |
| Answer» D. Ammonium chloride | |
| 154. |
This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = 0.48 H / Scr *[W/70]0.7 formula belong to? |
| A. | 1-6 years |
| B. | 1-20 years |
| C. | Males above 20 years |
| D. | Females above 20 years |
| Answer» B. 1-20 years | |
| 155. |
This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 – Age) W / 72 * Scr formula belong to? |
| A. | 1-6 years |
| B. | 1-20 years |
| C. | Males above 20 years |
| D. | Females above 20 years |
| Answer» C. Males above 20 years | |
| 156. |
This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 – Age) W / 85 * Scr formula belong to? |
| A. | 1-6 years |
| B. | 1-20 years |
| C. | Males above 20 years |
| D. | Females above 20 years |
| Answer» D. Females above 20 years | |
| 157. |
A girl with age 21 has height 240cm, weight 55kg, serum creatinine of 0.8mg will have ______________ creatinine clearance. |
| A. | 80 ml/min |
| B. | 90 ml/min |
| C. | 96.25 ml/min |
| D. | 85 ml/min |
| Answer» C. 96.25 ml/min | |
| 158. |
An adult male with age 22 has height 240cm, weight 85kg, serum creatinine of 0.8mg will have ______________ creatinine clearance. |
| A. | 150 ml/min |
| B. | 160 ml/min |
| C. | 170.13 ml/min |
| D. | 174.131 ml/min |
| Answer» D. 174.131 ml/min | |
| 159. |
Which creatinine clearance value shows moderate renal failure? |
| A. | 120-130 ml/min |
| B. | 20-50 ml/min |
| C. | Below 10 ml/min |
| D. | 70-80 ml/min |
| Answer» B. 20-50 ml/min | |
| 160. |
Which creatinine clearance value shows severe renal failure? |
| A. | 120-130 ml/min |
| B. | 20-50 ml/min |
| C. | Below 10 ml/min |
| D. | 70-80 ml/min |
| Answer» C. Below 10 ml/min | |
| 161. |
Drugs in patients with renal impairment have same pharmacokinetic profile as in a person without renal failure. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 162. |
Which kind of membrane is used in haemodialysis? |
| A. | Artificial Semipermeable membrane |
| B. | Permeable membrane |
| C. | Natural semipermeable membrane of the peritoneal cavity |
| D. | Artificial permeable membrane |
| Answer» A. Artificial Semipermeable membrane | |
| 163. |
Which kind of membrane is used in haemodialysis? |
| A. | Artificial Semipermeable membrane |
| B. | Permeable membrane |
| C. | Natural semipermeable membrane of peritoneal cavity |
| D. | Artificial permeable membrane |
| Answer» C. Natural semipermeable membrane of peritoneal cavity | |
| 164. |
Which of the following will not be a factor governing the removal of substances through dialysis? |
| A. | Molecular weight |
| B. | Water solubility |
| C. | Disintegration time |
| D. | Protein binding |
| Answer» C. Disintegration time | |
| 165. |
Haemodialysis is also known as extracorporeal dialysis. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 166. |
Which of the following is not a mechanism for pharmacokinetic analysis? |
| A. | Compartment analysis |
| B. | Non compartment analysis |
| C. | Physiologic modeling |
| D. | Human model |
| Answer» D. Human model | |
| 167. |
In which of the following models the body is considered to be composed of several compartments? |
| A. | Compartment model |
| B. | Noncompartment model |
| C. | Physiologic model |
| D. | Human model |
| Answer» A. Compartment model | |
| 168. |
In which of the model peripheral compartments are connected to a central compartment? |
| A. | Compartment model |
| B. | Caternary model |
| C. | Physiologic model |
| D. | Mammillary model |
| Answer» D. Mammillary model | |
| 169. |
Which organs will make up the peripheral compartment? |
| A. | Lungs |
| B. | Liver |
| C. | Kidneys |
| D. | Pancreas |
| Answer» D. Pancreas | |
| 170. |
In which model compartments are joined in series? |
| A. | Compartment model |
| B. | Caternary model |
| C. | Physiologic model |
| D. | Mammillary model |
| Answer» B. Caternary model | |
| 171. |
Which of the following is not a characteristic of the caternary compartment model? |
| A. | It gives a visual representation of various rate processes in drug disposition |
| B. | It shows how many rate constants are necessary |
| C. | Compartments and parameters bear a relationship with physiologic functions |
| D. | Useful in predicting drug |
| Answer» C. Compartments and parameters bear a relationship with physiologic functions | |
| 172. |
In noncompartmental analysis, Mean residence time is equal to _____________ |
| A. | The area under the first moment curve/area under the zero moment curve |
| B. | The area under the zero moment’s curve/area under the first moment curve |
| C. | 1 / Area under the first-moment curve |
| D. | 1/ Area under the zero moment curve |
| Answer» A. The area under the first moment curve/area under the zero moment curve | |
| 173. |
Which pharmacokinetic model is drawn on the basis of anatomic and physiologic data? |
| A. | Compartment model |
| B. | Caternary model |
| C. | Physiologic model |
| D. | Mammillary model |
| Answer» C. Physiologic model | |
| 174. |
Which of the following will be a disadvantage for the physiologic model? |
| A. | Prediction of drug concentration in various body regions |
| B. | Correlation of data in several animal species |
| C. | Obtaining experimental data for each of the organs |
| D. | The model gives an exact description of the drug concentration-time profile for any organ |
| Answer» C. Obtaining experimental data for each of the organs | |
| 175. |
Which model is also known as membrane permeation rate limited? |
| A. | Physiologic model |
| B. | Compartment model |
| C. | Noncompartment model |
| D. | Mammillary model |
| Answer» A. Physiologic model | |
| 176. |
What does the word “open” mean in the one compartment open model? |
| A. | The drug easily enters |
| B. | The drug readily mixes with the blood |
| C. | Unidirectional input and output |
| D. | Easy absorption |
| Answer» C. Unidirectional input and output | |
| 177. |
How much time does an intravenously administered drug take to complete a complete circulation? |
| A. | 5-8 min |
| B. | 7-10 min |
| C. | 1-3 min |
| D. | 1 min |
| Answer» C. 1-3 min | |
| 178. |
In the equation log C = log Co – KEt/2.303, what does Co stand for _______ |
| A. | Plasma drug concentration after 60 min of i.v. injection |
| B. | Plasma drug concentration after 15 min of i.v. injection |
| C. | Plasma drug concentration after 30 min of i.v. injection |
| D. | Plasma drug concentration immediately after i.v. injection. |
| Answer» D. Plasma drug concentration immediately after i.v. injection. | |
| 179. |
What is meant by elimination half-life? |
| A. | Time take for half of the amount of drug to get completely eliminated from only the organs |
| B. | Time take for half of the amount of drug to get completely eliminated from only blood |
| C. | Time take for half of the amount of drug to get completely eliminated from only plasma |
| D. | Time take for half of the amount of drug to get completely eliminated from the body as well as plasma |
| Answer» D. Time take for half of the amount of drug to get completely eliminated from the body as well as plasma | |
| 180. |
What is the equation to find out the apparent volume of distribution? |
| A. | Amount of drug in the body/plasma drug concentration |
| B. | Plasma drug concentration/amount of drug in the body |
| C. | 1 / plasma drug concentration |
| D. | 1 / Amount of drug in the body |
| Answer» A. Amount of drug in the body/plasma drug concentration | |
| 181. |
The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution? |
| A. | 625 mg/ml |
| B. | 625 l |
| C. | 625 ml |
| D. | 0.0016 mg/ml |
| Answer» C. 625 ml | |
| 182. |
To have a plasma distribution value of 900 ml and plasma drug concentration to be 1.2 mg/ml what should be the amount of drug that should be given to the patient? |
| A. | 1080 ml |
| B. | 1080 g |
| C. | 1080 mg |
| D. | 1g/ml |
| Answer» C. 1080 mg | |
| 183. |
What is the equation to find out hepatic clearance? |
| A. | Plasma drug concentration/rate of elimination by the kidney |
| B. | Rate of elimination by kidney/plasma drug concentration |
| C. | 1 / rate of elimination by the kidney |
| D. | 1 / plasma drug concentration |
| Answer» B. Rate of elimination by kidney/plasma drug concentration | |
| 184. |
Which organs comprise the central compartment in a two compartment model? |
| A. | Muscles |
| B. | Skin |
| C. | Adipose |
| D. | Liver |
| Answer» D. Liver | |
| 185. |
Which organ comprises the peripheral compartment in a two compartment model? |
| A. | Liver |
| B. | Lungs |
| C. | Kidneys |
| D. | Muscles |
| Answer» D. Muscles | |
| 186. |
Which of the following is not a category of 2 compartment model? |
| A. | Two compartment model with elimination from the central compartment |
| B. | Two compartment model with elimination from the peripheral compartment |
| C. | Two compartment model with elimination from only plasma and blood |
| D. | Two compartment model with elimination from both the compartments |
| Answer» D. Two compartment model with elimination from both the compartments | |
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