McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Uncategorized topics .
| 101. |
Which of the following concerning diamorphine elixir for the relief of pain in terminal patients is corrcet? |
| A. | Analgesia is enhanced if cocaine is added |
| B. | Constipation is a characteristic sequel to treatment |
| C. | Dependence occurs rapidly |
| D. | initial sedation typically continues whilst the drug is administered |
| E. | the same amount of pain relief is produced as when the same dose is given via intramuscular injection |
| Answer» B. Constipation is a characteristic sequel to treatment | |
| 102. |
In a case of Dysgerminoma of ovary tumor markers is likely to be raised.one of the following |
| A. | Serum HCG |
| B. | Serum alphafetoprotein |
| C. | Serum lactate dehydrogenase |
| D. | Serum inhibin |
| Answer» C. Serum lactate dehydrogenase | |
| 103. |
The most common pure germ cell tumor of the ovary is: |
| A. | Chriocarcinoma |
| B. | Dysgerminoma |
| C. | Embryonoal cell tumor |
| D. | Malignant Teratoma |
| Answer» B. Dysgerminoma | |
| 104. |
The highest incidence of Gestational Trophoblastic Disease is in: |
| A. | Australia |
| B. | Asia |
| C. | North America |
| D. | Westem Europe |
| Answer» B. Asia | |
| 105. |
According to the FIGO staging of gestational trophoblastic tumors, a lady with choriocarcinoma having lung metastasis will belong to which stage |
| A. | l |
| B. | ll |
| C. | lll |
| D. | lV |
| Answer» C. lll | |
| 106. |
A patient with non-metastatic gestational trophoblastic disease can be treated with weekly intramuscular injections of which of the following agents? |
| A. | Cyclophosphamide |
| B. | Carboplatin |
| C. | Etoposide |
| D. | Actinomycin D |
| E. | Methotrexate |
| Answer» E. Methotrexate | |
| 107. |
Five-year survival rates of patients with low-risk, non-metastatic gestational trophoblastic disease approaches? |
| A. | 100% |
| B. | 75% |
| C. | 50% |
| D. | 25% |
| E. | 5-10% |
| Answer» A. 100% | |
| 108. |
Comparing complete hydatidiform moles gestations, complete hydatidiform mole gestations are more likely than partial moles to demonstrate all of these characteristics except? |
| A. | More likely to require chemotherapy after evacuation for gestational trophablastic disease |
| B. | more likely to present with a uterus large for dates |
| C. | more likely to present with theca lutein cysts |
| D. | more likely to 'have focal rather than diffuse trophoblastic proliferation |
| E. | more likely to have diffuse hydopic swelling of villi |
| Answer» D. more likely to 'have focal rather than diffuse trophoblastic proliferation | |
| 109. |
A woman experiencing a molar pregnancy has an increased risk of which of the following in subsequent gestations ? |
| A. | Stillbirth |
| B. | Prematurity |
| C. | Congenital malformations |
| D. | Recurrent molar gestation |
| E. | Cancer later in life |
| Answer» D. Recurrent molar gestation | |
| 110. |
The most likely karyotype of patient with a complete mole would be ? |
| A. | 46, XX |
| B. | 46, XY |
| C. | Diandric triploidy |
| D. | Triploidy with two haploid sets of maternal origin |
| E. | Aneuploidy |
| Answer» A. 46, XX | |
| 111. |
The most likely karyotype for patient with a partial mole would be ? |
| A. | 46, XX |
| B. | 46, XY |
| C. | Diandric triploidy |
| D. | Triploidy with two haploid sets of maternal origin |
| E. | Aneuploidy |
| Answer» C. Diandric triploidy | |
| 112. |
A woman with a complete mole is most likely to present with which of the symptoms? |
| A. | Vaginal Bleeding |
| B. | Excessive uterine size |
| C. | Hypermesis |
| D. | Pre-eclampsia |
| E. | Prominent theca lutein cysts |
| Answer» A. Vaginal Bleeding | |
| 113. |
A patient with a complete mole is found to have sizeable ovarian cysts that are presumed to be theca lutein cysts. All of the following are true about theca lutein cysts EXCEPT? |
| A. | Such cysts arise more frequently in patients with complete moles |
| B. | Theca lutein cysts are more likely seen in patients with very high hCG levels |
| C. | Cysts are filled with serious or serosanguinous fluid and are usually bilateral |
| D. | Often require active management with surgical intervention |
| E. | Patients with large theca lutein cysts may be at increased risk for postmolar persistence of disease |
| Answer» D. Often require active management with surgical intervention | |
| 114. |
Regarding gestational trophoblastic disease (GTD),all are true except |
| A. | Incomplete moles are more likely to undergo malignant change than the complete moles |
| B. | GTD is almost always completely curable with preservation of fertility |
| C. | Lymphnode involvement is a rare feature of choriocarcinoma |
| D. | GTD usually shows low resistance blood flow |
| E. | It is rare to have other metastasis in the absence of lung metastasis |
| Answer» A. Incomplete moles are more likely to undergo malignant change than the complete moles | |
| 115. |
Risk of Malignancy in Adenomatous polyp is related to all except |
| A. | Size |
| B. | Number |
| C. | Histological appearance |
| D. | Dysplasia |
| Answer» B. Number | |
| 116. |
Polyps are generally managed endoscopically. Which of the following is not an indication for resectional surgery |
| A. | Lymphovascular invasion |
| B. | Poor differentiation |
| C. | Flat or ulcerated lesion |
| D. | Lesion in upper 1/3rd of submucosa |
| Answer» D. Lesion in upper 1/3rd of submucosa | |
| 117. |
Which of the following is not true for malignancy of Familial Adenomatous Polyposis |
| A. | Adrenals |
| B. | Thyroid |
| C. | Astrocytomas |
| D. | Hepatoblastomas |
| Answer» C. Astrocytomas | |
| 118. |
What is not true for HNPCC |
| A. | It is the most common hereditary colorectal cancer syndrome in USA |
| B. | It is associated with MMR gene mutation |
| C. | It is associated with APC mutation |
| D. | It is associated with carcinoma colon and extraintestinal cancers |
| E. | Answer C and D are correct |
| Answer» C. It is associated with APC mutation | |
| 119. |
True about Ulcerative Colitis with malignancy |
| A. | It has a better prognosis |
| B. | Is related to disease activity |
| C. | Is related to duration of ulcerative colitis |
| D. | Malignancy is more in anorectal ulcerative colitis |
| E. | All of above |
| Answer» C. Is related to duration of ulcerative colitis | |
| 120. |
In ulcerative coilitis with toxic megacolon lowest rate of recurrence is seen in |
| A. | Complete proctocolectomy and Brook's ileostomy |
| B. | Ileo rectal anastomoses |
| C. | kock's pouch |
| D. | none of above |
| Answer» A. Complete proctocolectomy and Brook's ileostomy | |
| 121. |
All are precancerous for carcinoma colon except |
| A. | Crohn's disease |
| B. | Bile acids |
| C. | Fats |
| D. | Carotene |
| Answer» D. Carotene | |
| 122. |
Which of these genetic risk factors has the highest association with colon cancers |
| A. | Sporadic |
| B. | Past family history of colo rectal cancer |
| C. | Hereditary Nonpolyposis colon cancer (HNPCC) |
| D. | Familial Adenomatous Polyposis (FAP) |
| Answer» A. Sporadic | |
| 123. |
After total proctocolectomy with ileal pouch anal anastomoses what is the most common cause of death in patients with Familial Adenomatous Polyposis (FAP) |
| A. | Gastric cancer |
| B. | Periampullary carcinoma |
| C. | Genito urinary cancers |
| D. | Recurrence of colorectal cancer |
| Answer» B. Periampullary carcinoma | |
| 124. |
Most valuable investigation for preoperative evaluation of extensive corrosive stricture is |
| A. | Endoscopic ultrasound |
| B. | Barium study |
| C. | CT Thorax |
| D. | Pharyngoscopy |
| Answer» A. Endoscopic ultrasound | |
| 125. |
Not an association between (PSC) Primary sclerosing cholangitis and Ulcerative colitis (UC) |
| A. | Inflammatory Bowel disease (IBD) seen in 70% of patients with PSC |
| B. | Diagnosis of IBD occurs 8-10 years before PSC |
| C. | Colitis is severe in patients with both PSC And UC as compared to UC alone |
| D. | Risk of colon cancer is more when patients have both UC and PSC as compared to UC alone |
| Answer» C. Colitis is severe in patients with both PSC And UC as compared to UC alone | |
| 126. |
Which is the most accurate method of detecting colon cancer |
| A. | Fecal occult blood |
| B. | PET/CT |
| C. | Sigmoidoscopy |
| D. | Colonoscopy |
| E. | Digital examination |
| Answer» D. Colonoscopy | |
| 127. |
What is the most appropriate treatment for T3 colon cancer |
| A. | Surgery alone |
| B. | Chemotherapy alone |
| C. | Radiotherapy alone |
| D. | Surgery plus chemotherapy |
| E. | Supportive care only |
| Answer» D. Surgery plus chemotherapy | |
| 128. |
Radiotherapy is indicated in |
| A. | aT3 colon cancer |
| B. | T2 colon cancer |
| C. | T3 rectal cancer |
| D. | T1 rectal cancer |
| E. | T1 colon cancer |
| Answer» C. T3 rectal cancer | |
| 129. |
Concerning small intestinal fistulae, all the following are true EXCEPT: |
| A. | A fistula may have a high output or a low output depending on its site. |
| B. | High output fistulae occur in the upper small bowel. |
| C. | Low output fistulae occur in the ileum. |
| D. | Isotonic saline should be used to replace intravascular and interstitial volume in high output fistulae |
| E. | The lower the fistula the higher the fluid and nutrient loss. |
| Answer» E. The lower the fistula the higher the fluid and nutrient loss. | |
| 130. |
Concerning colonic polyps: |
| A. | Polyposis means the presence of hundreds of polyps, usually in the small intestine. |
| B. | Pedunculated polyps are more likely to become malignant than sessile ones. |
| C. | Villous adenomas are associated with hyperkalaemia. |
| D. | Metaplastic polyps commonly become malignant. |
| E. | Most adenocarcinomas arise within pre-existing adenomas. |
| Answer» E. Most adenocarcinomas arise within pre-existing adenomas. | |
| 131. |
A 45 years old male with bilateral breast cancer with his mother developed breast cancer when aged 34 years and his sister developed ovarian cancer at age 50 years. The most likely genetic mutation for this patient is/are |
| A. | BRAC1 |
| B. | BRCA2 |
| C. | ATM |
| D. | APC |
| E. | Answer A and B are correct |
| Answer» B. BRCA2 | |
| 132. |
A 45 years old female with right sided breast cancer with no family history suggesting familial cancer. The most likely genetic mutation for this patient is/are |
| A. | BRAC1 |
| B. | BRCA2 |
| C. | ATM |
| D. | APC |
| E. | Answer A and B are correct |
| Answer» B. BRCA2 | |
| 133. |
Chromosomal 17 has many genes implicated in molecular criteria of breast cancer including these genes EXCEPT: |
| A. | BRCA-1 |
| B. | HER-2 |
| C. | P53 |
| D. | ATM |
| E. | Answer B and D are correct. |
| Answer» D. ATM | |
| 134. |
Concerning adenomatous polyps, all the following are true EXCEPT: |
| A. | They may cause anaemia |
| B. | They may cause diarrhea |
| C. | They occur mainly in the ileum |
| D. | They may initiate an intussusception |
| E. | They have a malignant potential |
| Answer» C. They occur mainly in the ileum | |
| 135. |
Familial polyposis coli |
| A. | is inherited as autosomal recessive |
| B. | is more common in male |
| C. | cancer develops after the age of 50 in untreated patients |
| D. | polyps develop throughout the colon and rectum early in the second decade of life |
| E. | the responsible gene is on the long arm of chromosome 6 |
| Answer» D. polyps develop throughout the colon and rectum early in the second decade of life | |
| 136. |
Gardner's syndrome is associated with all the following EXCEPT: |
| A. | multiple colorectal adenomas |
| B. | sebaceous and dermoid cysts |
| C. | adenomas of the mandible or skull |
| D. | desmoid tumors of the abdominal wall |
| E. | no malignant potential |
| Answer» E. no malignant potential | |
| 137. |
All the following may predispose to colorectal cancer EXCEPT |
| A. | Familial adenomatous polyposis |
| B. | High fibre, low fat diets |
| C. | Ulcerative colitis |
| D. | Schistosomal colitis |
| E. | Exposure to irradiation |
| Answer» B. High fibre, low fat diets | |
| 138. |
Genes implicated in the pathogenesis of colorectal cancer include all the following EXCEPT: |
| A. | Ki-ras gene |
| B. | c-myc gene |
| C. | APC gene |
| D. | BRCA1 gene |
| E. | P53 gene. |
| Answer» D. BRCA1 gene | |
| 139. |
The carcinoid syndrome is likely to occur with carcinoid tumors: |
| A. | of the appendix |
| B. | localized to the ileum |
| C. | both |
| D. | neither |
| Answer» D. neither | |
| 140. |
Carcinoid tumors (argentaffinomas) are characterized by all of the following except: |
| A. | many are multiple especially in the ileum |
| B. | can occur in alimentary, biliary and respiratory tracts |
| C. | may produce systemic symptoms when accompanied by liver metastases |
| D. | appendix is the most common site |
| E. | appendiceal types have greatest malignant potential |
| Answer» E. appendiceal types have greatest malignant potential | |
| 141. |
Primary carcinoma is least common in: |
| A. | esophagus |
| B. | stomach |
| C. | small intestine |
| D. | colon |
| Answer» C. small intestine | |
| 142. |
Which is most characteristic of carcinoma of the cecum or right colon (in contrast to carcinoma of the rectum)? |
| A. | anemia |
| B. | associated polyposis |
| C. | bowel obstruction |
| D. | diarrhea |
| Answer» A. anemia | |
| 143. |
In which of the following segments of the gastrointestinal tract is primary carcinoma least common? |
| A. | esophagus |
| B. | stomach |
| C. | small intestine |
| D. | colon |
| E. | mouth |
| Answer» C. small intestine | |
| 144. |
Bilateral ovarian metastases presenting as tumor masses are most characteristically associated with carcinoma of the: |
| A. | esophagus |
| B. | stomach |
| C. | small intestine |
| D. | appendix |
| E. | colon |
| Answer» B. stomach | |
| 145. |
The worst prognosis is associated with carcinoma of the: |
| A. | esophagus |
| B. | stomach |
| C. | small intestine |
| D. | colon |
| Answer» A. esophagus | |
| 146. |
Diffuse intramural spread with extensive fibroblastic thickening is a morphologic pattern most characteristically associated with carcinoma of the |
| A. | esophagus |
| B. | stomach |
| C. | small intestine |
| D. | appendix |
| E. | colon |
| Answer» B. stomach | |
| 147. |
Carcinoid tumors have a varied malignant potential. The most benign are located in the: |
| A. | stomach |
| B. | small intestine |
| C. | rectum |
| D. | appendix |
| Answer» D. appendix | |
| 148. |
Which of the following characterizes the biologic nature of carcinoid tumors (argentaffinomas)? |
| A. | benign but produce systemic symptoms |
| B. | production of systemic symptoms when they metastasize to the liver |
| C. | especially malignant when primary in the appendix |
| D. | production of jejunal ulceration due to gastrin elaboration |
| Answer» B. production of systemic symptoms when they metastasize to the liver | |
| 149. |
In the colon, which is benign and has no significant tendency to undergo malignant transformation? |
| A. | familial polyposis |
| B. | juvenile polyp |
| C. | villous adenoma |
| D. | carcinoid tumors |
| Answer» B. juvenile polyp | |
| 150. |
Carcinoma of the esophagus: |
| A. | produces symptoms early and is more curable than carcinoma of the stomach |
| B. | is difficult to cure because of local spread |
| C. | is characterized by early widespread metastases |
| D. | is usually undifferentiated |
| Answer» B. is difficult to cure because of local spread | |
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