McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 51. |
Drug having ……..half-lives take a very short time to achieve plateau concentration. |
| A. | shorter |
| B. | longer |
| C. | intermediate |
| D. | none of the above |
| Answer» A. shorter | |
| 52. |
The primary pharmacokinetic parameter clearance can be calculated by |
| A. | Cl = KV |
| B. | Cl = Dose/AUC |
| C. | Cl = (dA/dt)/C |
| D. | all of the above |
| Answer» D. all of the above | |
| 53. |
………..change in drug kinetics is known as chronokinetics. |
| A. | Time-dependent |
| B. | Dose-dependent |
| C. | Both (a) & (b) |
| D. | None of the above |
| Answer» A. Time-dependent | |
| 54. |
Constant rate infusion prevents………..in blood levels. |
| A. | fluctuations |
| B. | peak maximum |
| C. | valley minimum |
| D. | all of the above |
| Answer» D. all of the above | |
| 55. |
Constant rate infusion is…….. |
| A. | prevents fluctuations |
| B. | useful when drug has narrow TI |
| C. | Both (a) & (b) |
| D. | none of the above |
| Answer» C. Both (a) & (b) | |
| 56. |
Concentration of drug at peak is known as …………drug concentration. |
| A. | maximum |
| B. | minimum |
| C. | lower |
| D. | none of the above |
| Answer» A. maximum | |
| 57. |
In one compartment open model, the term open indicates input and output is: |
| A. | unidirectional |
| B. | bidirectional |
| C. | non-directional |
| D. | none of the above |
| Answer» A. unidirectional | |
| 58. |
The mathematical relationship between plasma drug concentration and pharmacological response is called as……….. |
| A. | PK modeling |
| B. | PD modeling |
| C. | PK-PD modeling |
| D. | None of the above |
| Answer» C. PK-PD modeling | |
| 59. |
The ratio of maximum safe concentration to minimum effective concentration is called as |
| A. | Therapeutic index |
| B. | Therapeutic range |
| C. | Therapeutic outcome |
| D. | Therapeutic ratio |
| Answer» A. Therapeutic index | |
| 60. |
Half life of zero-order process is proportional to of drug. |
| A. | initial concentration |
| B. | final concentration |
| C. | both (a) & (b) |
| D. | none of the above |
| Answer» A. initial concentration | |
| 61. |
The ability of liver to excrete drug in bile is expressed by……… |
| A. | hepatic clearance |
| B. | biliary clearance |
| C. | non-renal clearance |
| D. | renal clearance |
| Answer» B. biliary clearance | |
| 62. |
…………..is nothing but manner in which drug should be taken. |
| A. | dosing frequency |
| B. | dosage regimen |
| C. | dose adjustment |
| D. | none of the above |
| Answer» B. dosage regimen | |
| 63. |
What is dosage regimen? |
| A. | The concentration of active agent in the drug formulation |
| B. | The manner in which the drug is given to old people |
| C. | The manner in which a drug is taken |
| D. | The manner in which drug given to child |
| Answer» C. The manner in which a drug is taken | |
| 64. |
What is optimal multiple dosage regimen? |
| A. | The concentration of active agent in the drug formulation |
| B. | Dosage which maintains the plasma concentration within the therapeutic window. |
| C. | The manner in which a drug is taken |
| D. | The manner in which drug given to child |
| Answer» B. Dosage which maintains the plasma concentration within the therapeutic window. | |
| 65. |
On what basis the dose interval is calculated? |
| A. | Active drug concentration in the formulation |
| B. | Half-life of the drug |
| C. | Duration of the disease |
| D. | Age of the patient |
| Answer» B. Half-life of the drug | |
| 66. |
What is fluctuation? |
| A. | Cmax/Cmin |
| B. | Cmin / Cmax |
| C. | 1/Cmin |
| D. | 1/Cmax |
| Answer» A. Cmax/Cmin | |
| 67. |
How do you calculate the ideal body weight for men? |
| A. | 50 kg +- 1kg/2.5cm above or below 150 cm in height |
| B. | 45 kg +- 1kg/2.5cm above or below 150 cm in height |
| C. | 40 kg +- 1kg/2.5cm above or below 150 cm in height |
| D. | 35 kg +- 1kg/2.5cm above or below 150 cm in height |
| Answer» A. 50 kg +- 1kg/2.5cm above or below 150 cm in height | |
| 68. |
How do you calculate the ideal body weight for a woman? |
| A. | 50 kg +- 1kg/2.5cm above or below 150 cm in height |
| B. | 45 kg +- 1kg/2.5cm above or below 150 cm in height |
| C. | 40 kg +- 1kg/2.5cm above or below 150 cm in height |
| D. | 35 kg +- 1kg/2.5cm above or below 150 cm in height |
| Answer» B. 45 kg +- 1kg/2.5cm above or below 150 cm in height | |
| 69. |
Which of the following drugs are lipid soluble? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» A. Phenytoin | |
| 70. |
Which of the following drugs get distributed to the same extent in both lean and adipose tissue? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» B. Caffeine | |
| 71. |
Which of the following drugs can get distributed to the excess body space of obese patient? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» D. Antibiotics | |
| 72. |
Which of the following drug can get distributed in the excess body space? |
| A. | Phenytoin |
| B. | Caffeine |
| C. | Digoxin |
| D. | Antibiotics |
| Answer» C. Digoxin | |
| 73. |
Neonates, infants and children require different dosages than adults. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 74. |
Accumulation occurs because drug from previous doses was not being removed completely. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 75. |
The renal clearance of a drug bound to plasma protein is increased after displacement with another drug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 76. |
Which of the following promotes excretion of acidic drugs? |
| A. | Citrates |
| B. | Ammonium chloride |
| C. | Methionine |
| D. | Ascorbic acid |
| Answer» A. Citrates | |
| 77. |
Which of the following promotes the excretion of basic drugs? |
| A. | Tartarates |
| B. | Citrates |
| C. | Bicarbonates |
| D. | Ammonium chloride |
| Answer» D. Ammonium chloride | |
| 78. |
This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = 0.48 H / Scr *[W/70]0.7 formula belong to? |
| A. | 1-6 years |
| B. | 1-20 years |
| C. | Males above 20 years |
| D. | Females above 20 years |
| Answer» B. 1-20 years | |
| 79. |
This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 – Age) W / 72 * Scr formula belong to? |
| A. | 1-6 years |
| B. | 1-20 years |
| C. | Males above 20 years |
| D. | Females above 20 years |
| Answer» C. Males above 20 years | |
| 80. |
This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 – Age) W / 85 * Scr formula belong to? |
| A. | 1-6 years |
| B. | 1-20 years |
| C. | Males above 20 years |
| D. | Females above 20 years |
| Answer» D. Females above 20 years | |
| 81. |
A girl with age 21 has height 240cm, weight 55kg, serum creatinine of 0.8mg will have ______________ creatinine clearance. |
| A. | 80 ml/min |
| B. | 90 ml/min |
| C. | 96.25 ml/min |
| D. | 85 ml/min |
| Answer» C. 96.25 ml/min | |
| 82. |
An adult male with age 22 has height 240cm, weight 85kg, serum creatinine of 0.8mg will have ______________ creatinine clearance. |
| A. | 150 ml/min |
| B. | 160 ml/min |
| C. | 170.13 ml/min |
| D. | 174.131 ml/min |
| Answer» D. 174.131 ml/min | |
| 83. |
Which creatinine clearance value shows moderate renal failure? |
| A. | 120-130 ml/min |
| B. | 20-50 ml/min |
| C. | Below 10 ml/min |
| D. | 70-80 ml/min |
| Answer» B. 20-50 ml/min | |
| 84. |
Which creatinine clearance value shows severe renal failure? |
| A. | 120-130 ml/min |
| B. | 20-50 ml/min |
| C. | Below 10 ml/min |
| D. | 70-80 ml/min |
| Answer» C. Below 10 ml/min | |
| 85. |
Drugs in patients with renal impairment have same pharmacokinetic profile as in a person without renal failure. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 86. |
Which kind of membrane is used in haemodialysis? |
| A. | Artificial Semipermeable membrane |
| B. | Permeable membrane |
| C. | Natural semipermeable membrane of the peritoneal cavity |
| D. | Artificial permeable membrane |
| Answer» A. Artificial Semipermeable membrane | |
| 87. |
Which kind of membrane is used in haemodialysis? |
| A. | Artificial Semipermeable membrane |
| B. | Permeable membrane |
| C. | Natural semipermeable membrane of peritoneal cavity |
| D. | Artificial permeable membrane |
| Answer» A. Artificial Semipermeable membrane | |
| 88. |
Which of the following will not be a factor governing the removal of substances through dialysis? |
| A. | Molecular weight |
| B. | Water solubility |
| C. | Disintegration time |
| D. | Protein binding |
| Answer» C. Disintegration time | |
| 89. |
Haemodialysis is also known as extracorporeal dialysis. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 90. |
Which of the following is not a mechanism for pharmacokinetic analysis? |
| A. | Compartment analysis |
| B. | Non compartment analysis |
| C. | Physiologic modeling |
| D. | Human model |
| Answer» D. Human model | |
| 91. |
In which of the following models the body is considered to be composed of several compartments? |
| A. | Compartment model |
| B. | Noncompartment model |
| C. | Physiologic model |
| D. | Human model |
| Answer» A. Compartment model | |
| 92. |
In which of the model peripheral compartments are connected to a central compartment? |
| A. | Compartment model |
| B. | Caternary model |
| C. | Physiologic model |
| D. | Mammillary model |
| Answer» D. Mammillary model | |
| 93. |
Which organs will make up the peripheral compartment? |
| A. | Lungs |
| B. | Liver |
| C. | Kidneys |
| D. | Pancreas |
| Answer» D. Pancreas | |
| 94. |
In which model compartments are joined in series? |
| A. | Compartment model |
| B. | Caternary model |
| C. | Physiologic model |
| D. | Mammillary model |
| Answer» B. Caternary model | |
| 95. |
Which of the following is not a characteristic of the caternary compartment model? |
| A. | It gives a visual representation of various rate processes in drug disposition |
| B. | It shows how many rate constants are necessary |
| C. | Compartments and parameters bear a relationship with physiologic functions |
| D. | Useful in predicting drug |
| Answer» C. Compartments and parameters bear a relationship with physiologic functions | |
| 96. |
In noncompartmental analysis, Mean residence time is equal to _____________ |
| A. | The area under the first moment curve/area under the zero moment curve |
| B. | The area under the zero moment’s curve/area under the first moment curve |
| C. | 1 / Area under the first-moment curve |
| D. | 1/ Area under the zero moment curve |
| Answer» A. The area under the first moment curve/area under the zero moment curve | |
| 97. |
Which pharmacokinetic model is drawn on the basis of anatomic and physiologic data? |
| A. | Compartment model |
| B. | Caternary model |
| C. | Physiologic model |
| D. | Mammillary model |
| Answer» C. Physiologic model | |
| 98. |
Which of the following will be a disadvantage for the physiologic model? |
| A. | Prediction of drug concentration in various body regions |
| B. | Correlation of data in several animal species |
| C. | Obtaining experimental data for each of the organs |
| D. | The model gives an exact description of the drug concentration-time profile for any organ |
| Answer» C. Obtaining experimental data for each of the organs | |
| 99. |
Which model is also known as membrane permeation rate limited? |
| A. | Physiologic model |
| B. | Compartment model |
| C. | Noncompartment model |
| D. | Mammillary model |
| Answer» A. Physiologic model | |
| 100. |
What does the word “open” mean in the one compartment open model? |
| A. | The drug easily enters |
| B. | The drug readily mixes with the blood |
| C. | Unidirectional input and output |
| D. | Easy absorption |
| Answer» C. Unidirectional input and output | |
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