McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 301. |
Which vitamin molecules will bind to alpha 2 globulin? |
| A. | Vitamin b complexes |
| B. | Vitamin a and vitamin b |
| C. | Vitamin A, D, E, K |
| D. | Steroids bind to alpha 2 globulin, not vitamin |
| Answer» C. Vitamin A, D, E, K | |
| 302. |
What is the molecular weight of human serum albumin? |
| A. | 5000 Dalton |
| B. | 65,000 Dalton |
| C. | 60,000 Dalton |
| D. | 75,000 Dalton |
| Answer» B. 65,000 Dalton | |
| 303. |
HSA comes under which protein family? |
| A. | Globulin |
| B. | Receptor |
| C. | Enzymes |
| D. | Catalyst |
| Answer» B. Receptor | |
| 304. |
What is the name of the drug binding site I of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» D. Warfarin and azapropazone binding site | |
| 305. |
Which one of the below does not belong to the 4 classes of lipoprotein? |
| A. | Chylomicrons |
| B. | Very low-density lipoproteins |
| C. | High-density lipoprotein |
| D. | Fatty acids |
| Answer» D. Fatty acids | |
| 306. |
Which of the given drugs bind to Α1 globulin? |
| A. | Steroidal drugs |
| B. | Vitamins A, D, E, K |
| C. | Ferrous ions |
| D. | Carotenoids |
| Answer» A. Steroidal drugs | |
| 307. |
What is the name of the drug binding site IV of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» A. Tamoxifen binding site | |
| 308. |
Acidic drugs like imipramine, lidocaine bind to alpha 1 Acid Glycoprotein. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 309. |
Which of the given drugs bind to Β2 globulin? |
| A. | Steroidal drugs |
| B. | Vitamins A, D, E, K |
| C. | Ferrous ions |
| D. | Carotenoids |
| Answer» D. Carotenoids | |
| 310. |
What is the name of the drug binding site III of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» B. Digitoxin binding site | |
| 311. |
Which drugs bind to RBC membrane? |
| A. | Pentobarbital |
| B. | Acetazolamide |
| C. | Imipramine |
| D. | Phenytoin |
| Answer» C. Imipramine | |
| 312. |
What is the name of the drug binding site II of HSA? |
| A. | Tamoxifen binding site |
| B. | Digitoxin binding site |
| C. | Diazepam binding site |
| D. | Warfarin and azapropazone binding site |
| Answer» C. Diazepam binding site | |
| 313. |
Which one of the following factors related to protein-drug binding is not related to drugs? |
| A. | Physicochemical characteristics of a drug |
| B. | The concentration of the drug in the body |
| C. | The affinity of the drug for binding |
| D. | Number of binding sites on the binding agent |
| Answer» D. Number of binding sites on the binding agent | |
| 314. |
Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site? |
| A. | Competition between the drug and the binding site |
| B. | Competition between drugs and normal body constituents |
| C. | Allosteric changes in a protein molecule |
| D. | Inter subject variation |
| Answer» D. Inter subject variation | |
| 315. |
Which of the following factors for protein drug binding is a drug interaction factor? |
| A. | Competition between drugs for the binding site |
| B. | Age |
| C. | Physicochemical characteristics of a drug |
| D. | Physicochemical characteristics of the protein or binding agent |
| Answer» A. Competition between drugs for the binding site | |
| 316. |
Which drugs bind to HSA easily? |
| A. | Cationic drug |
| B. | Anionic drug |
| C. | Lipophilic drug |
| D. | Neutral drug |
| Answer» B. Anionic drug | |
| 317. |
Which drugs easily bind to adipose tissue? |
| A. | Cationic drug |
| B. | Anionic drug |
| C. | Lipophilic drug |
| D. | Neutral drug |
| Answer» C. Lipophilic drug | |
| 318. |
Which drug easily bind to AAG? |
| A. | Cationic drug |
| B. | Anionic drug |
| C. | Lipophilic drug |
| D. | Neutral drug |
| Answer» A. Cationic drug | |
| 319. |
The extent of drug-protein binding can change with both changes in protein and drug concentration. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 320. |
In the equation X= Vd C, what does X stands for? |
| A. | Amount of drug in the blood |
| B. | Amount of drug in plasma |
| C. | Amount of drug in the tablet |
| D. | Amount of drug in the body |
| Answer» D. Amount of drug in the body | |
| 321. |
Only unbound or free drug is capable of being eliminated. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 322. |
Penicillin has short plasma half-life although it can bind to plasma protein rigidly. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 323. |
Displacement interactions are significant in the case of drugs which are more than 95% bound. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 324. |
Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration. |
| A. | CuC |
| B. | C / Cu |
| C. | Cu/C |
| D. | 1/C Cu |
| Answer» C. Cu/C | |
| 325. |
The value of association constant, Ka and the number of binding sites N can be obtained by |
| A. | Direct plot |
| B. | Scatchard plot |
| C. | Klotz plot |
| D. | All of the above |
| Answer» D. All of the above | |
| 326. |
Which of the following drug bind to α1 globulin? |
| A. | Steroids |
| B. | Ferrous ion |
| C. | Carotenoid |
| D. | Vitamin D |
| Answer» A. Steroids | |
| 327. |
What is interaction of phenobarbitone and warfarin? |
| A. | Displacement of warfarin from binding site |
| B. | Decreased absorption of warfarin |
| C. | Increase metabolism of warfarin |
| D. | Decreased metabolism of warfarin |
| Answer» A. Displacement of warfarin from binding site | |
| 328. |
Which process involves alteration of drug distribution? |
| A. | Competitive binding |
| B. | Reduced plasma protein level |
| C. | Both |
| D. | None |
| Answer» C. Both | |
| 329. |
Two most common protein involved in plasma protein binding are |
| A. | Globulin and plasmin |
| B. | Albumin and globulin |
| C. | Fibrin and globulin |
| D. | Plasmin and fibrin |
| Answer» B. Albumin and globulin | |
| 330. |
All of the following displace imipramine from protein binding site except |
| A. | Aspirin |
| B. | Phenytoin |
| C. | Ethosuximide |
| D. | Phenylbutazone |
| Answer» C. Ethosuximide | |
| 331. |
The drugs which are most affected in pregnancy are those having |
| A. | Low protein binding and high Vd |
| B. | High protein binding and low Vd |
| C. | High protein binding and high Vd |
| D. | Low protein binding and low Vd |
| Answer» B. High protein binding and low Vd | |
| 332. |
Most of drugs will bind with which of plasma protein |
| A. | Albumin |
| B. | Globulin |
| C. | Histone |
| D. | Glycoprotein |
| Answer» A. Albumin | |
| 333. |
Which of the following is not highly protein bound drug |
| A. | Barbiturates |
| B. | Phenylbutazone |
| C. | Salicylates |
| D. | Aspirin |
| Answer» D. Aspirin | |
| 334. |
Blood plasma belongs to |
| A. | Interstitial fluid |
| B. | Intracellular fluid |
| C. | Extracellular fluid |
| D. | All of the above |
| Answer» A. Interstitial fluid | |
| 335. |
Drug elimination involves....... (ADME are steps of pharmacokinetics) |
| A. | ADME |
| B. | DME |
| C. | ME |
| D. | E only |
| Answer» C. ME | |
| 336. |
Filtration fraction is |
| A. | Fraction of plasma passing through the kidney which is filtered at glomerulus |
| B. | Ratio of iulin clearance to PAH clearance |
| C. | Ration of CFR to RPF |
| D. | None of them |
| Answer» C. Ration of CFR to RPF | |
| 337. |
Creatinine clearance is used as measurement for |
| A. | Glomerular filtration rate |
| B. | Renal excretion rate |
| C. | Passive renal excretion |
| D. | Drug metabolism rate |
| Answer» A. Glomerular filtration rate | |
| 338. |
What is the half life of a drug with a volume of distribution of 100U70kg and a clearance of 7t/hr/70kg |
| A. | 15 hours |
| B. | 10 hours |
| C. | 13.5 hours |
| D. | 5 hours |
| Answer» B. 10 hours | |
| 339. |
A Normal sized adult having hepatic clearance of a drug whose metabolism is limited by the rate of blood flow to the liver would be |
| A. | 60 milliliters/min |
| B. | 120 milliliters/min |
| C. | 650 milliliters/min |
| D. | 1500 milliliters/min |
| Answer» D. 1500 milliliters/min | |
| 340. |
Which process involves alteration in drug excretion? |
| A. | Increased fluid flow |
| B. | Changes in urinary pH |
| C. | Both |
| D. | None |
| Answer» C. Both | |
| 341. |
Which of the following is not a step of renal excretion? |
| A. | Glomerular filtration |
| B. | Tubular filtration |
| C. | Tubular reabsorption |
| D. | Secretion |
| Answer» B. Tubular filtration | |
| 342. |
Renal clearance is expressed as |
| A. | Rate of urinary excretion / Plasma drug concentration |
| B. | Elimination Rate / Plasma drug concentration |
| C. | Rate of urinary excretion / Elimination Rate |
| D. | Elimination Rate |
| Answer» A. Rate of urinary excretion / Plasma drug concentration | |
| 343. |
Glomerular filtration rate would be increased by |
| A. | constriction of the afferent arteriole |
| B. | decrease in afferent arteriolar pressure |
| C. | compression of the renal capsule |
| D. | decrease in the concentration of plasma protein |
| Answer» D. decrease in the concentration of plasma protein | |
| 344. |
The volume of plasma needed each minute to supply a substance at the rate at which it is excreted in the urine is known as the |
| A. | diffusion constant of the substance |
| B. | clearance of the substance |
| C. | extraction ratio of the substance |
| D. | filtration rate of the substance |
| Answer» B. clearance of the substance | |
| 345. |
Nephron is functional unit of………….. |
| A. | Kidney |
| B. | Heart |
| C. | Lung |
| D. | Liver |
| Answer» A. Kidney | |
| 346. |
Hepatic extraction ratio of 0.60 indicates that |
| A. | 40% drug is left after extraction by the liver |
| B. | 60% drug is left after extraction by the liver |
| C. | Only 0.6% drug is removed by the liver |
| D. | None of the above |
| Answer» A. 40% drug is left after extraction by the liver | |
| 347. |
First pas metabolism occurs in: |
| A. | Liver |
| B. | In lungs |
| C. | In kidneys |
| D. | In pancreas |
| Answer» A. Liver | |
| 348. |
The term "biotransformation" includes the following. |
| A. | Accumulation of substances in a fat tissue |
| B. | Process of physicochemical and biochemical alteration of a drug in the body |
| C. | Binding of substances with plasma proteins |
| D. | Accumulation of substances in a tissue |
| Answer» B. Process of physicochemical and biochemical alteration of a drug in the body | |
| 349. |
For the calculation of the volume of distribution (Vd) one take into account: |
| A. | Concentration of a substance in urine |
| B. | Concentration of substance in plasma |
| C. | A daily dose of drug |
| D. | Therapeutic width of drug action |
| Answer» B. Concentration of substance in plasma | |
| 350. |
Biotransformation of a medicinal substance results in: |
| A. | Slower urinary excretion |
| B. | Faster urinary excretion |
| C. | Higher binding to membranes |
| D. | Easier distribution in organism |
| Answer» B. Faster urinary excretion | |
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