McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 151. |
The deleterious effect of various coatings on drug dissolution is shown in orders below. Which one of them is the correct order? |
| A. | Enteric coat > sugar coat > nonenteric film coat |
| B. | Enteric coat > nonenteric film coat > sugar coat |
| C. | Nonenteric film coat > sugar coat > enteric coat |
| D. | Sugar coat > enteric coat > nonenteric film coat |
| Answer» A. Enteric coat > sugar coat > nonenteric film coat | |
| 152. |
Which of the following will be an example of an organic suspending agent? |
| A. | CMC |
| B. | MC |
| C. | Acacia |
| D. | Carbowaxes |
| Answer» C. Acacia | |
| 153. |
Which one of these is not a mechanism of the working of surfactants? |
| A. | Promote wetting by increasing the effective surface area |
| B. | Helps in the dissolution of drug |
| C. | Better membrane contact of the drug |
| D. | Decrease membrane permeability |
| Answer» D. Decrease membrane permeability | |
| 154. |
PABA complex is used for the enhancement of ______________ |
| A. | Enhanced chelation |
| B. | Enhanced dissolution |
| C. | Enhanced membrane permeability |
| D. | Enhanced lipophilicity |
| Answer» D. Enhanced lipophilicity | |
| 155. |
The concentration of colorant does not affect the drug solubility. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 156. |
Suspending agent and some sugars can be used as viscosity imparters. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 157. |
According to the pH-partition hypothesis which one of the given options doesn’t govern the absorption? |
| A. | The molecular size of the drug |
| B. | PH at the absorption site |
| C. | Lipid solubility of unionized drugs |
| D. | Dissociation constant |
| Answer» A. The molecular size of the drug | |
| 158. |
If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 159. |
Which of the following equations correct for Henderson-Hasselbach equation for weak acids? |
| A. | PH = pKa – log (Unionized drug concentration /Ionized drug concentration) |
| B. | PH = pKa – log (Ionized drug concentration/ Unionized drug concentration) |
| C. | PH = pKa + log (Ionized drug concentration/ Unionized drug concentration) |
| D. | PH = pKa + log (Unionized drug concentration /Ionized drug concentration) |
| Answer» C. PH = pKa + log (Ionized drug concentration/ Unionized drug concentration) | |
| 160. |
Which of the following equations correct for Henderson-Hasselbach equation for weak bases? |
| A. | PH = pKa – log (Unionized drug concentration /Ionized drug concentration) |
| B. | PH = pKa – log (Ionized drug concentration/ Unionized drug concentration) |
| C. | PH = pKa + log (Ionized drug concentration/ Unionized drug concentration) |
| D. | PH = pKa + log (Unionized drug concentration /Ionized drug concentration) |
| Answer» D. PH = pKa + log (Unionized drug concentration /Ionized drug concentration) | |
| 161. |
What is the pH range of the stomach? |
| A. | 1-4 |
| B. | 5-8 |
| C. | 1-3 |
| D. | 1-8 |
| Answer» C. 1-3 | |
| 162. |
What is the pH range of the intestine? |
| A. | 4-5 |
| B. | 1-3 |
| C. | 1-8 |
| D. | 5-8 |
| Answer» D. 5-8 | |
| 163. |
Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 164. |
Which one of these is an example of a strong acid drug? |
| A. | Diazepam |
| B. | Ibuprofen |
| C. | Cromolyn |
| D. | Aspirin |
| Answer» C. Cromolyn | |
| 165. |
Which one of these is not an example of a basic drug with pKa range 5-11? |
| A. | Cromolyn |
| B. | Imipramine |
| C. | Amitriptyline |
| D. | Chloroquine |
| Answer» A. Cromolyn | |
| 166. |
Example of a drug which has PKa > 11 is ________ |
| A. | Cromolyn |
| B. | Imipramine |
| C. | Amitriptyline |
| D. | Mecamylamine |
| Answer» D. Mecamylamine | |
| 167. |
What should be the range of oil/water partition coefficient of any drug? |
| A. | 1-2 |
| B. | 3-4 |
| C. | 2-3 |
| D. | 1-3 |
| Answer» A. 1-2 | |
| 168. |
Ibuprofen a weak acid, in the stomach will be present in which of the given form? |
| A. | Ionized form mostly |
| B. | Non-ionized form mostly |
| C. | Half ionized and half no ionized |
| D. | Will form aggregate |
| Answer» B. Non-ionized form mostly | |
| 169. |
Nitrazepam a weak base, will be in which form in the stomach? |
| A. | Ionized form mostly |
| B. | Non-ionized form mostly |
| C. | Half ionized and half no ionized |
| D. | Will form aggregate |
| Answer» A. Ionized form mostly | |
| 170. |
All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 171. |
Heroin with pKa 7.8 will be in which form in intestinal pH? |
| A. | Ionized form mostly |
| B. | Unionized form mostly |
| C. | Half ionized and half no ionized |
| D. | Will form aggregate |
| Answer» B. Unionized form mostly | |
| 172. |
Which one of these options is not one of the limitations of pH-partition theory? |
| A. | Presence if virtual membrane pH |
| B. | Absorption of ionized drugs |
| C. | Influence of GI surface area |
| D. | Dissolution rate |
| Answer» D. Dissolution rate | |
| 173. |
A microclimate pH, different from the luminal pH exists at the membrane surface. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 174. |
According to the pH-partition theory which form of the drug gets absorbed mostly? |
| A. | Hydrated form |
| B. | Aggregated form |
| C. | Ionised |
| D. | Unionised |
| Answer» D. Unionised | |
| 175. |
What helps the ionized drug molecules to pass through the cell membrane passively? |
| A. | Different pH |
| B. | Polar group |
| C. | Large lipophilic group |
| D. | Hydration |
| Answer» C. Large lipophilic group | |
| 176. |
Acidic drugs are best absorbed through the stomach and basic drugs are best absorbed through the intestine. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 177. |
What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine? |
| A. | More surface area |
| B. | Long residence time |
| C. | Large surface area and long residence time |
| D. | Large surface area, long residence time, basic pH |
| Answer» C. Large surface area and long residence time | |
| 178. |
Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 179. |
What are the major stability problems which result in poor bioavailability of any orally administered drugs? |
| A. | Acidic degradation |
| B. | Degradation by salivary amylase |
| C. | Degradation of the drug in inactive form |
| D. | Interaction with the excipients and degradation in an inactive form |
| Answer» D. Interaction with the excipients and degradation in an inactive form | |
| 180. |
What is the mean length of GIT? |
| A. | 350 cm |
| B. | 200cm |
| C. | 400cm |
| D. | 450cm |
| Answer» D. 450cm | |
| 181. |
The entire length of the GI is lined by ___________ |
| A. | Blood vessels |
| B. | Nerves |
| C. | Mucopolysaccharides |
| D. | No lining direct contact with the cell |
| Answer» C. Mucopolysaccharides | |
| 182. |
Which drugs get absorbed in the stomach mostly? |
| A. | Basic drugs |
| B. | Acidic Drugs |
| C. | Neutral drugs |
| D. | No drug gets absorbed in the stomach |
| Answer» B. Acidic Drugs | |
| 183. |
Which drugs gets mostly absorbed from the mouth? |
| A. | Acidic drugs and lipophilic drugs |
| B. | Lipophilic drugs and neutral drugs |
| C. | Neutral drugs and lipophilic drugs |
| D. | Lipophilic, neutral, basic drugs |
| Answer» A. Acidic drugs and lipophilic drugs | |
| 184. |
From the surface of villi protrude smaller projection known as __________ |
| A. | Microvilli |
| B. | Villus |
| C. | Fingers |
| D. | Cilia |
| Answer» A. Microvilli | |
| 185. |
Which of the following sentences will be the actual definition of folds of Kerckring? |
| A. | Folds of the intestinal mucosa |
| B. | Finger-like projections whose other name is villi |
| C. | Protruding surface from the villi |
| D. | Cilia over the surface of villi |
| Answer» A. Folds of the intestinal mucosa | |
| 186. |
Which one of the following is not a characteristic for the small intestine? |
| A. | Peristaltic movement |
| B. | Long transit time |
| C. | High permeability |
| D. | PH 4-9 |
| Answer» D. PH 4-9 | |
| 187. |
How can we increase the time of gastric emptying? |
| A. | By drinking a lot of water |
| B. | By taking a drug in empty stomach |
| C. | By taking the drug after food |
| D. | Cannot increase the time of gastric emptying at all |
| Answer» C. By taking the drug after food | |
| 188. |
What is gastric emptying rate? |
| A. | The time required for the gastric contents to empty into the small intestine |
| B. | Time is taken for half of the contents in the stomach to empty |
| C. | The speed at which the stomach contents empty into the intestine |
| D. | There is no such term |
| Answer» C. The speed at which the stomach contents empty into the intestine | |
| 189. |
How can we study the gastric emptying of a given drug? |
| A. | By mixing the colour with the drug |
| B. | Waiting for the subject man to throw-up |
| C. | Tagging the drug with a radioisotope and scanning the stomach |
| D. | Waiting for the patient to pass feces |
| Answer» C. Tagging the drug with a radioisotope and scanning the stomach | |
| 190. |
Up to how much the microvilli in the small intestine increases the relative surface area of the small intestine? |
| A. | 3 times |
| B. | 30 times |
| C. | 100 times |
| D. | 600 times |
| Answer» D. 600 times | |
| 191. |
What is the main role of the large intestine? |
| A. | Absorption of water and electrolytes |
| B. | Absorption of minerals |
| C. | Absorption of glucose |
| D. | Absorption of only water |
| Answer» A. Absorption of water and electrolytes | |
| 192. |
The liver is the major site of drug metabolism. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 193. |
In infants, the gastric pH is quite low. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 194. |
The passage from the stomach to the small intestine is called gastric emptying. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 195. |
Which one is the sublingual route? |
| A. | Drug placed between cheek and gum |
| B. | Drug place between the tongue and upper palate |
| C. | Drug placed under the tongue |
| D. | Drug crushed and placed under the tongue |
| Answer» C. Drug placed under the tongue | |
| 196. |
Which one of the following is the buccal route? |
| A. | Drug placed between cheek and gum |
| B. | Drug place between the tongue and upper palate |
| C. | Drug placed under the tongue |
| D. | Drug crushed and placed under the tongue |
| Answer» A. Drug placed between cheek and gum | |
| 197. |
Which one of the following is not an advantage of sublingual or buccal administration? |
| A. | Rapid absorption and higher blood levels |
| B. | No first-pass hepatic metabolism |
| C. | No degradation of drugs |
| D. | Limited surface area |
| Answer» D. Limited surface area | |
| 198. |
Which is the largest organ of the human body? |
| A. | Liver |
| B. | Stomach |
| C. | Skin |
| D. | Lungs |
| Answer» C. Skin | |
| 199. |
What is the principal barrier for the drugs on the topical application? |
| A. | The Dermis |
| B. | The subcutaneous fat tissue |
| C. | The stratum corneum |
| D. | The blood vessels below the skin |
| Answer» C. The stratum corneum | |
| 200. |
Which of the following decreasing order of blood flow rate through the muscular tissue is in the right order? |
| A. | Arm > thigh > buttocks |
| B. | Arm > buttocks > thigh |
| C. | Buttocks > thigh > arm |
| D. | Thigh > arm > buttocks |
| Answer» A. Arm > thigh > buttocks | |
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