McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) , Pharmacy .
Chapters
| 251. |
Which one of the following dosage forms exhibit faster rate of reaction under normal conditions? |
| A. | emulsions |
| B. | ointments |
| C. | solutions |
| D. | suspensions |
| Answer» C. solutions | |
| 252. |
In chemical kinetics, the rate of a reaction is expressed as (-dc/dt), where dc refers to the concentration. Whose concentration does it refer to? |
| A. | catalyst |
| B. | product |
| C. | reactant |
| D. | solvent medium |
| Answer» C. reactant | |
| 253. |
Which one of the following can be designated as the molecularity of a reaction? |
| A. | half |
| B. | one |
| C. | one and half |
| D. | zero |
| Answer» B. one | |
| 254. |
Which one of them is refered as a general rate equation (-dc/dt) for a second order? |
| A. | A°B° |
| B. | A1B1 |
| C. | A1B2 |
| D. | A2B2 |
| Answer» B. A1B1 | |
| 255. |
Which-one of the following orders have abundant applications in biological processes? |
| A. | first |
| B. | second |
| C. | third |
| D. | zero |
| Answer» A. first | |
| 256. |
In a chemical reaction, the rate constant is independent of the initial concentration. Which one of them is the order? |
| A. | first |
| B. | second |
| C. | third |
| D. | zero |
| Answer» D. zero | |
| 257. |
Chemical kinetics is the study of the |
| A. | rate of chemical reactions |
| B. | particle size |
| C. | rheological property |
| D. | interfacial tension |
| Answer» A. rate of chemical reactions | |
| 258. |
Rate of reaction is the |
| A. | number of reactant molecules or atoms that take part in chemical reactions to give the products. |
| B. | sum of exponents or powers of concentration terms in the rate equation |
| C. | time required for reactant concentration to decrease to 90% of the initial concentration. |
| D. | speed at which chemical reaction takes place |
| Answer» D. speed at which chemical reaction takes place | |
| 259. |
When rate is independent of the reactant concentration, then it is called |
| A. | zero order reaction. |
| B. | Pseudo zero order reaction |
| C. | First order reaction |
| D. | Second order reaction |
| Answer» A. zero order reaction. | |
| 260. |
In the equation, Rate = k[C]c[D]d, the order of the above reaction is |
| A. | k |
| B. | C + D |
| C. | [C] *[D] |
| D. | c + d |
| Answer» D. c + d | |
| 261. |
Which of the following is the half life of zero order reaction |
| A. | t1/2 = Ao/2k |
| B. | t1/2 = 0.693/2k |
| C. | t1/2 = Ao/2 |
| D. | t1/2 = 2k/ Ao |
| Answer» A. t1/2 = Ao/2k | |
| 262. |
The unit of k for zero order reaction is |
| A. | moles/litre/second |
| B. | moles |
| C. | moles/second |
| D. | moles/litre |
| Answer» A. moles/litre/second | |
| 263. |
Which of the following is the half life of first order reaction |
| A. | t1/2 = A0/2k |
| B. | t1/2 = 0.693/2k |
| C. | t1/2 = 2k |
| D. | t1/2 = 0.693/k |
| Answer» D. t1/2 = 0.693/k | |
| 264. |
The unit of rate constant for second order reaction is |
| A. | litre.mole-2 sec-2 |
| B. | litre.mole-2 sec-1 |
| C. | litre |
| D. | litre.mole-1 sec-1 |
| Answer» D. litre.mole-1 sec-1 | |
| 265. |
Which of the following method/s used for determination of order of reaction? |
| A. | Graphic method |
| B. | Substitution method |
| C. | Half life method |
| D. | All of the above - |
| Answer» D. All of the above - | |
| 266. |
The value of t1/2 for second order reaction is |
| A. | 1/ak |
| B. | 0.693/k |
| C. | Ao/2k |
| D. | Ao/2 |
| Answer» A. 1/ak | |
| 267. |
The accelerated stability studies are primarily used to determine: |
| A. | energy of the activation of the reaction |
| B. | k value at elevated temperatures |
| C. | k value at the room temperature |
| D. | shelf life of the product |
| Answer» D. shelf life of the product | |
| 268. |
The specific rate constant (k) determined for aspirin hydrolysis in pH 1.0 buffer at 1 mg/ml concentration is 2.0x10-3 min-1 at 25°C. The shelf life of the product is (in minutes): |
| A. | 2.0 |
| B. | 52 |
| C. | 104 |
| D. | 346 |
| Answer» B. 52 | |
| 269. |
In general, reaction rate constants in neutral pH are comparatively: |
| A. | equal |
| B. | higher |
| C. | lower |
| D. | zero |
| Answer» C. lower | |
| 270. |
The expiry date for a tablet is not mentioned on the label. It means that the expiry time in years is: |
| A. | five years |
| B. | nil |
| C. | three years |
| D. | two years |
| Answer» A. five years | |
| 271. |
Penicillin G is prepared as a salt of procaine penicillin G. Now the rate of decomposition of penicillin G will be: |
| A. | increased |
| B. | reduced |
| C. | unchanged |
| D. | unpredictable |
| Answer» B. reduced | |
| 272. |
According to International Pharmaceutical Federation, the recommended overages be limited to the maximum percent of: |
| A. | five |
| B. | ten |
| C. | thirty |
| D. | twenty |
| Answer» C. thirty | |
| 273. |
Usually, the rate of a chemical reaction may be enhanced by: |
| A. | cooling the reaction mixture |
| B. | increasing the rate of stirring |
| C. | raising the temperature of the reaction mixture |
| D. | using stoichiometric quantities of each reactant |
| Answer» C. raising the temperature of the reaction mixture | |
| 274. |
Which of the following expression is correct for the determination of shelf life for a first order decomposition? |
| A. | t1/2 = 0.105/k |
| B. | t90 = 0.693/k |
| C. | t1/2 = 0.693/k |
| D. | t90 = 0.105/k |
| Answer» D. t90 = 0.105/k | |
| 275. |
Regarding the influence of the solvent on the rate of reaction, solvents having the internal pressure: |
| A. | HIGHER produce products with HIGHER internal pressure |
| B. | HIGHER favour the formation of products having LOWER internal pressure |
| C. | LOWER yield products having HIGHER internal pressure |
| D. | LOWER retard the formation of products with LOWER internal pressure |
| Answer» A. HIGHER produce products with HIGHER internal pressure | |
| 276. |
During autoclaving of dextrose solution, a straw colour is observed. It is due to the presence of a substance called: |
| A. | furfural |
| B. | 5-hydroxymethylfurfural |
| C. | 5-hydroxyfurfural |
| D. | 5-methylfurfural |
| Answer» B. 5-hydroxymethylfurfural | |
| 277. |
In injections, procaine undergoes the degradation reactions in the following sequence: |
| A. | decarboxylation and hydrolysis |
| B. | hydrolysis and decarboxylation |
| C. | hydrolysis, decarboxylation and oxidation |
| D. | oxidation, decarboxylation and hydrolysis |
| Answer» B. hydrolysis and decarboxylation | |
| 278. |
On a product, the label states ‘protect from light’. What type of decomposition does the product undergo? |
| A. | carboxylation |
| B. | decarboxylation |
| C. | hydrolysis |
| D. | oxidation |
| Answer» D. oxidation | |
| 279. |
Which of the following reactions is observed in the degradation of ampicillin? |
| A. | decarboxylation |
| B. | hydrolysis |
| C. | oxidation |
| D. | recimization |
| Answer» B. hydrolysis | |
| 280. |
Aspirin undergoes decomposition in a formulation. It can be prevented by: |
| A. | adding a chelating agent |
| B. | adding an antioxidant |
| C. | protecting it from light |
| D. | suppressing its solubility |
| Answer» D. suppressing its solubility | |
| 281. |
Which one of the following is primarily NOT a chemical decomposition? |
| A. | isomerisation |
| B. | hydrolysis |
| C. | oxidation |
| D. | volatilization |
| Answer» D. volatilization | |
| 282. |
For the validity of accelerated stability studies of solution dosage form, the energy of activation should be in the range of (in units of kcal/mole). |
| A. | 0 to 10 |
| B. | 11 to 30 |
| C. | 31 to 50 |
| D. | 51 to 70 |
| Answer» B. 11 to 30 | |
| 283. |
Which one of these methods is the MOST effective in preventing the rate of hydrolysis? |
| A. | buffer |
| B. | complexation |
| C. | removal of water |
| D. | suppression of solubility |
| Answer» C. removal of water | |
| 284. |
During storage, crystal growth is observed in a suspension due to: |
| A. | absorption of water |
| B. | fluctuations in the ambient temperatures |
| C. | presence of suspending agent |
| D. | volatilization of solids |
| Answer» B. fluctuations in the ambient temperatures | |
| 285. |
The storage directions on a parenteral solution specify ‘store in a cool place’. This may be stored in: |
| A. | an air-conditioned area at 10°C |
| B. | a refrigerator at 15°C |
| C. | a place whose temperature is set at 5°C |
| D. | room temperature, at 25°C |
| Answer» B. a refrigerator at 15°C | |
| 286. |
which of the following is cause of physical degradation of drug? |
| A. | volatilisation of components during storage |
| B. | Changes from one state to another |
| C. | Change in colour |
| D. | All of the above |
| Answer» D. All of the above | |
| 287. |
Which of the following factors affect the rate of reaction? |
| A. | Temperature |
| B. | Catalysis |
| C. | Dielectric constant |
| D. | All of the above |
| Answer» D. All of the above | |
| 288. |
The effect of temperature on rate of reaction is explained by |
| A. | Arrhenius equation |
| B. | Nernst equation |
| C. | Noyes Whitney equation |
| D. | Fick's first law |
| Answer» A. Arrhenius equation | |
| 289. |
The unit of activation energy is |
| A. | kJ/mol |
| B. | J |
| C. | N/m |
| D. | mm |
| Answer» A. kJ/mol | |
| 290. |
The dielectric constant is used to measure |
| A. | Viscosity of solvent |
| B. | polarity of the solvent |
| C. | temperature of solvent |
| D. | flowability of solvent |
| Answer» B. polarity of the solvent | |
| 291. |
Accelerated stability testing is done to |
| A. | predict shelf of the formulation |
| B. | Predict dissociation constant |
| C. | Predict diffusion constant |
| D. | Determine activation energy |
| Answer» A. predict shelf of the formulation | |
| 292. |
ICH stands for |
| A. | Indian council on harmonisation |
| B. | International Conference On Harmonisation |
| C. | Inter Cranial Healer |
| D. | None of the above |
| Answer» B. International Conference On Harmonisation | |
| 293. |
Stability Data for Climatic zone III & IV comes under___________ICH guideline |
| A. | Q1C |
| B. | Q1E |
| C. | Q1F |
| D. | Q1D |
| Answer» C. Q1F | |
| 294. |
Climatic zone II is |
| A. | Moderate climate |
| B. | Subtropical and Mediterranean climate |
| C. | Hot/dry climate |
| D. | Hot/humid climate |
| Answer» B. Subtropical and Mediterranean climate | |
| 295. |
Stability testing is done |
| A. | to determine shelf life of product |
| B. | to determine the components used for packaging |
| C. | to get information at preformulation stage |
| D. | All of the above |
| Answer» D. All of the above | |
| 296. |
........... is the time necessary for the concentration of the reactant to decrease to 90% of its original concentration. |
| A. | Product life |
| B. | Shelf life |
| C. | Half life |
| D. | None of the above |
| Answer» B. Shelf life | |
| 297. |
Generally, Stability testing is employed for........... |
| A. | Delivering evidences of the change in quality of the drug product with time. |
| B. | Confirming shelf life for the drug product. |
| C. | Determining container closure system suitability. |
| D. | All of the above |
| Answer» D. All of the above | |
| 298. |
A zero-order reaction is a reaction having rate of concentration of reactant. |
| A. | Dependent |
| B. | Partially dependent |
| C. | Independent |
| D. | None of the above |
| Answer» C. Independent | |
| 299. |
In a second-order reaction, the sum of the exponents in the rate law is equal to............... |
| A. | Zero |
| B. | One |
| C. | Two |
| D. | Three |
| Answer» C. Two | |
| 300. |
..........technique is utilized only during determination of order of reaction, when the rate law involved by only single concentration term. |
| A. | The concentration |
| B. | The half of the concentration |
| C. | The square of the concentration |
| D. | None of the above |
| Answer» C. The square of the concentration | |
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