McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 51. |
According to pH partition theory, a weak acidic drug will most likely be absorbed from the stomach because the drug which exist primarily in the |
| A. | Unionized, more lipid soluble form |
| B. | Ionised, more water soluble form |
| C. | Form of weak acid and more soluble in acid media |
| D. | Ionic form of the drug, which facilitates diffusion |
| Answer» A. Unionized, more lipid soluble form | |
| 52. |
Very weak bases having pKa < 5 |
| A. | Are ionized in the entire pH range of GIT |
| B. | Show absorption, which is pH dependent |
| C. | Are unionized at all pH values |
| D. | None of the above |
| Answer» C. Are unionized at all pH values | |
| 53. |
IV route of drug administration does not involve………… |
| A. | distribution step |
| B. | absorption step |
| C. | biotransformation step |
| D. | All of the above |
| Answer» B. absorption step | |
| 54. |
In carrier mediated transport energy is derived from…….. |
| A. | Hydrolysis of ATP |
| B. | Protein metabolism |
| C. | Concentration gradient |
| D. | All of the above |
| Answer» A. Hydrolysis of ATP | |
| 55. |
Which of the following drug is not stable in the gastric fluid? |
| A. | Erythromycin |
| B. | Paracetamol |
| C. | Salicylic acid |
| D. | none of the above |
| Answer» A. Erythromycin | |
| 56. |
………types of drugs are absorbed by pore transport mechanism. |
| A. | Macromolecules |
| B. | Ionic drugs |
| C. | Drugs with molecular weight 100-400 |
| D. | Water soluble drugs of molecular weight less than 100 |
| Answer» D. Water soluble drugs of molecular weight less than 100 | |
| 57. |
Area in which the carrier system is most dense is called as………….. |
| A. | Therapeutic window |
| B. | Absorption index |
| C. | Therapeutic index |
| D. | Absorption window |
| Answer» D. Absorption window | |
| 58. |
Which of the following is carrier mediated transport system |
| A. | passive diffusion |
| B. | active transport |
| C. | pore transport |
| D. | none of the above |
| Answer» B. active transport | |
| 59. |
Absorption of poorly soluble drug is |
| A. | diffusion rate limited |
| B. | dissolution rate limited |
| C. | both (a) & (b) |
| D. | none of the above |
| Answer» B. dissolution rate limited | |
| 60. |
Which of the following process drug moves from site of administration to systemic circulation? |
| A. | excretion |
| B. | absorption |
| C. | distribution |
| D. | metabolism |
| Answer» B. absorption | |
| 61. |
Based on Henderson-Hasselbalch equation, at what pH value a weak acid would be 99.9% ionized? |
| A. | At pH equivalent to pKa - 3 |
| B. | At pH equivalent to pKa + 3 |
| C. | At pH equivalent to pKa – 1 |
| D. | At pH equivalent to pKa + 1 |
| Answer» B. At pH equivalent to pKa + 3 | |
| 62. |
In passive diffusion, the transport of drugs takes place from a region of ……………concentration to a ……………..concentration. |
| A. | Lower, Higher |
| B. | Higher, Lower |
| C. | Both (a) and (b) |
| D. | none of the above |
| Answer» B. Higher, Lower | |
| 63. |
Which is the major process of absorption for more than 90% of drugs? |
| A. | Facilitated diffusion |
| B. | Active transport |
| C. | Endocytosis |
| D. | Passive diffusion |
| Answer» D. Passive diffusion | |
| 64. |
What is the driving force for Passive Diffusion? |
| A. | Concentration gradient only |
| B. | Electrochemical gradient only |
| C. | Charge equilibration and concentration gradient |
| D. | Concentration and Electrochemical gradient both |
| Answer» D. Concentration and Electrochemical gradient both | |
| 65. |
Which kind of molecules cannot pass through a pore transport? |
| A. | Low Molecular weight molecules |
| B. | Water-soluble drugs |
| C. | Molecules up to 400 Dalton |
| D. | Molecules greater than 400 Dalton |
| Answer» D. Molecules greater than 400 Dalton | |
| 66. |
What is the driving force of Pore Transport? |
| A. | Hydrostatic pressure |
| B. | Concertation Gradient |
| C. | Electrochemical gradient |
| D. | Charge equilibration |
| Answer» A. Hydrostatic pressure | |
| 67. |
What will be the best definition for “carrier”? |
| A. | Nonpolar drugs can be transported through carrier-mediated transport |
| B. | Carrier binds reversibly and no covalently with the molecules |
| C. | It discharges the molecules and gets destroyed itself |
| D. | The carrier is a protein |
| Answer» B. Carrier binds reversibly and no covalently with the molecules | |
| 68. |
What is the major difference between Facilitated diffusion and Passive diffusion? |
| A. | Carrier-mediated transport |
| B. | Downhill transport |
| C. | Energy is used |
| D. | Inhibition by metabolic poisons |
| Answer» A. Carrier-mediated transport | |
| 69. |
What influences the permeation of drugs in an Ionic or Electrochemical diffusion? |
| A. | Charge on the membrane |
| B. | Charge on the particle |
| C. | Concentration gradient |
| D. | Equilibration of charge |
| Answer» A. Charge on the membrane | |
| 70. |
Which kind of drugs are absorbed through endocytosis? |
| A. | Molecular weight ranging 100-400Dalton |
| B. | Water-soluble drugs |
| C. | Macromolecular drugs or drugs as oily droplets |
| D. | Polar drugs |
| Answer» C. Macromolecular drugs or drugs as oily droplets | |
| 71. |
Which drugs are absorbed through pore transport? |
| A. | High lipophilicity |
| B. | Water-soluble drugs of molecular weight less than 100 Dalton |
| C. | Oily droplets |
| D. | Affinity for carriers |
| Answer» B. Water-soluble drugs of molecular weight less than 100 Dalton | |
| 72. |
Which types of drugs get absorbed by ion-pair transport? |
| A. | High lipophilicity |
| B. | Oily droplets |
| C. | Affinity for carriers |
| D. | Drugs that ionize at all pH conditions |
| Answer» D. Drugs that ionize at all pH conditions | |
| 73. |
Which of these absorption methods involves engulfing of the extracellular drug? |
| A. | Endocytosis |
| B. | Passive diffusion |
| C. | Facilitated diffusion |
| D. | Ion-Pair tr |
| Answer» A. Endocytosis | |
| 74. |
Which is the other name of “cell eating”? |
| A. | Transcytosis |
| B. | Phagocytosis |
| C. | Pinocytosis |
| D. | Endocytosis |
| Answer» B. Phagocytosis | |
| 75. |
Transfer of an endocytic vesicle from one extracellular compartment to another is known as |
| A. | Phagocytosis |
| B. | Transcytosis |
| C. | Pinocytosis |
| D. | Endocytosis |
| Answer» B. Transcytosis | |
| 76. |
A drug can be absorbed by more than one mechanism. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 77. |
Which kind of absorption mechanism is showing in the picture? |
| A. | Endocytosis |
| B. | Passive transport |
| C. | Active transport |
| D. | Facilitated diffusion |
| Answer» B. Passive transport | |
| 78. |
Which one of these is a physicochemical property of Drug substance? |
| A. | Drug solubility |
| B. | Disintegration time |
| C. | Age of patient |
| D. | Dissolution time |
| Answer» A. Drug solubility | |
| 79. |
Which one of these does not come under a physicochemical property of drugs? |
| A. | Drug solubility |
| B. | Disintegration time |
| C. | Dissolution rate |
| D. | Drug stability |
| Answer» B. Disintegration time | |
| 80. |
In the sequence of events in the drug absorption from orally administered solid dosage, which one comes at first? |
| A. | Disintegration |
| B. | Disaggregation |
| C. | Dissolution |
| D. | Absorption |
| Answer» A. Disintegration | |
| 81. |
Which one is the correct sequence for drug absorption through the oral route? |
| A. | Absorption – Dissolution – Disintegration – Deaggregation |
| B. | Disintegration – Dissolution – Deaggregation – Absorption |
| C. | Disintegration – Deaggregation – Dissolution – Absorption |
| D. | Disintegration – Deaggregation – Absorption – Dissolution |
| Answer» C. Disintegration – Deaggregation – Dissolution – Absorption | |
| 82. |
Patient-related factors of drug absorption do not deal with which one of these? |
| A. | Age |
| B. | Gastric Emptying time |
| C. | Intestinal transit time |
| D. | Pharmaceutic ingredients |
| Answer» D. Pharmaceutic ingredients | |
| 83. |
The rate at which drug reaches the systemic circulation is determined by the slowest of the various steps involved in the sequence. This is known as ____________ |
| A. | Disintegration time |
| B. | Dissolution time |
| C. | Rate limiting step |
| D. | Gastric Emptying time |
| Answer» C. Rate limiting step | |
| 84. |
Diffusion coefficient of drug D, Greater the value faster us the dissolution. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 85. |
Greater the surface area lesser is the dissolution. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 86. |
Which one of the following is a critical rate-limiting step of drug absorption? |
| A. | Rate of drug disintegration |
| B. | Size of the drug |
| C. | Size of the porous particle |
| D. | Rate of dissolution |
| Answer» D. Rate of dissolution | |
| 87. |
Which sentence will define the Dissolution rate? |
| A. | Amount of solid substrate that goes into solution under constant time |
| B. | Amount of solid substrate that goes into solution under constant time under standard temperature |
| C. | Amount of solid substrate that goes into solution under constant time under standard temperature, pH, and pressure |
| D. | Amount of solid substrate that goes into solution under constant time under standard temperature, pH, solvent composition and constant surface area |
| Answer» D. Amount of solid substrate that goes into solution under constant time under standard temperature, pH, solvent composition and constant surface area | |
| 88. |
What should be the ideal solubility rate of an orally administered drug in the pH range of 2 to 8? |
| A. | 3-4mg/ml |
| B. | 4-6 mg/ml |
| C. | 7-8 mg/ml |
| D. | 1-2 mg/ml |
| Answer» D. 1-2 mg/ml | |
| 89. |
Which one of these is not a theory of Drug dissolution? |
| A. | Diffusion layer model |
| B. | Fick’s law of diffusion |
| C. | Penetration or surface renewal theory |
| D. | Interfacial barrier model |
| Answer» B. Fick’s law of diffusion | |
| 90. |
Which theory takes into account that a thin film is created by the solution of the solid at the solidliquid interface? |
| A. | Interfacial barrier model |
| B. | Diffusion layer model |
| C. | Penetration or surface renewal theory |
| D. | Danckwert’s model |
| Answer» B. Diffusion layer model | |
| 91. |
In the equation G=Ki (Cs-Cb), what does G stands for______________ |
| A. | Dissolution rate per unit area |
| B. | Effective interfacial transport constant |
| C. | Concentration of the solute |
| D. | Concentration of the impurity |
| Answer» A. Dissolution rate per unit area | |
| 92. |
Which model does not approve the existence of the stagnant layer in the solid-liquid interface? |
| A. | Interfacial barrier model |
| B. | Diffusion layer model |
| C. | Penetration or surface renewal theory |
| D. | Danckwert’s model |
| Answer» D. Danckwert’s model | |
| 93. |
What does the interfacial barrier model states? |
| A. | An intermediate concentration exists at the interface |
| B. | Turbulence in the dissolution medium exists at the solid/liquid interface |
| C. | Formation a thin film or layer at the solid-liquid interface |
| D. | Solutes passes easily through the interfaces |
| Answer» A. An intermediate concentration exists at the interface | |
| 94. |
In the equation, Wo1/3-W1/3=Kt, K stands for ____________ |
| A. | The original mass of the drug |
| B. | Mass of the drug remaining after time t |
| C. | Dissolution constant |
| D. | Concentration of solute |
| Answer» C. Dissolution constant | |
| 95. |
Which are the two rate-determining step of drug absorption when given orally? |
| A. | Disintegration and deaggregation |
| B. | Disintegration and Dissolution |
| C. | Dissolution and permeation through the membrane |
| D. | Permeation through the membrane and Disintegration |
| Answer» C. Dissolution and permeation through the membrane | |
| 96. |
The maximum amount of solute dissolved in a given solvent under standard conditions of temperature, pressure, and pH is known as __________ |
| A. | Dissolution rate |
| B. | Intrinsic dissolution |
| C. | Rate limiting step |
| D. | Absolute or intrinsic solubility |
| Answer» D. Absolute or intrinsic solubility | |
| 97. |
In the equation, V dC/dt = dm/dt = A(Cs-Cb).√ γ D, what does γ stands for? |
| A. | Mass of the solid dissolved |
| B. | Rate of surface renewal |
| C. | Concentration of solute |
| D. | Concentration of the drug |
| Answer» B. Rate of surface renewal | |
| 98. |
Each face of the crystal has a different interfacial barrier. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 99. |
Absorption of drugs can be categorized into 2 classes, physicochemical properties of drugs and Dosage form of the drug, on the basis of drug dissolution. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 100. |
Which option will be the best example of the physicochemical properties of drugs? |
| A. | Solubility, particle size, polymorphism, salt form, pseudo polymorphism, complexation, wettability, pH, Pressure of disintegration |
| B. | Pressure of disintegration, polymorphism, salt form, pseudo polymorphism, complexation, wettability, pH |
| C. | Solubility, particle size, polymorphism, salt form |
| D. | Solubility, particle size, polymorphism, salt form, pseudo polymorphism, complexation, wettability |
| Answer» D. Solubility, particle size, polymorphism, salt form, pseudo polymorphism, complexation, wettability | |
Done Studing? Take A Test.
Great job completing your study session! Now it's time to put your knowledge to the test. Challenge yourself, see how much you've learned, and identify areas for improvement. Don’t worry, this is all part of the journey to mastery. Ready for the next step? Take a quiz to solidify what you've just studied.