McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Bachelor of Pharmacy (B. Pharma) .
Chapters
| 101. |
For oral formulation, what should be the minimum aqueous solubility to avoid bioavailability problems? |
| A. | 0.9% |
| B. | 1% |
| C. | 2% |
| D. | 0.11% |
| Answer» B. 1% | |
| 102. |
The total solid surface area of any particle is known as ___________ |
| A. | Absolute surface area |
| B. | Effective surface area |
| C. | Total surface area |
| D. | Surface area |
| Answer» A. Absolute surface area | |
| 103. |
Particle size and surface area of a drug are directly related to each other. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 104. |
Absolute surface area is proportional to the dissolution rate of a drug. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 105. |
In the case of hydrophobic drugs, micronization results in a decrease in effective surface area and thus fall is dissolution rate. Which of the below sentences cannot be a reason for the given statement? |
| A. | The hydrophobic surface of the drugs adsorbs onto their surface which inhibits their wettability |
| B. | The particles reaggregate to form larger particles due to their high surface free energy |
| C. | Extreme reduction in the particle size imparts surface charges that may prevent wetting |
| D. | Extreme reduction in the size brings the hydrophobic amino acids to the surface |
| Answer» D. Extreme reduction in the size brings the hydrophobic amino acids to the surface | |
| 106. |
How the absolute surface area of hydrophobic drugs can be converted to their effective surface area? |
| A. | Use of surfactant |
| B. | Use of Hydrophobic diluents |
| C. | Use of surfactant and hydrophilic diluents |
| D. | No need of doing micronization |
| Answer» C. Use of surfactant and hydrophilic diluents | |
| 107. |
Which one of these is not an example of hydrophilic diluents? |
| A. | PVC |
| B. | Dextrose |
| C. | PVP |
| D. | PEG |
| Answer» A. PVC | |
| 108. |
The solvate can exist in different crystalline forms called as _________ |
| A. | Solvates |
| B. | Pseudopolymorphs |
| C. | Pseudopolymorphism |
| D. | Hydrate |
| Answer» B. Pseudopolymorphs | |
| 109. |
Which form of a drug has greater solubility? |
| A. | Anhydrous |
| B. | Hydrate |
| C. | Crystallised |
| D. | Monohydrate |
| Answer» A. Anhydrous | |
| 110. |
Which one will be the easiest approach to enhance the solubility and dissolution of any drug? |
| A. | Micronize the drug |
| B. | Convert drug into their anhydrous form |
| C. | Convert drug into their hydrous form |
| D. | Convert drug into their salt form |
| Answer» D. Convert drug into their salt form | |
| 111. |
What is pH? |
| A. | –ve log of H+ concentration |
| B. | +ve log of H+ concentration |
| C. | Log of H+ concentration |
| D. | H+ concentration |
| Answer» A. –ve log of H+ concentration | |
| 112. |
Which one of these is not an advantage of buffered aspirin tablets? |
| A. | Enhanced bioavailability |
| B. | Reduced gastric irritation |
| C. | Increased stability |
| D. | Increased ulcerogenic tendency |
| Answer» D. Increased ulcerogenic tendency | |
| 113. |
Larger the size of the counterion, greater the solubility. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 114. |
Which of the following will be the slowest step in tablet drug absorption? |
| A. | Tablet disintegration to granules |
| B. | Granules disintegration to fine particles |
| C. | Fine particles dissolution |
| D. | Dissolution absorbed into the blood |
| Answer» A. Tablet disintegration to granules | |
| 115. |
Aging of dosage form affects drug release. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 116. |
Which form of the drug has the highest bioavailability? |
| A. | Coated tablets |
| B. | Solutions |
| C. | Tablets |
| D. | Emulsions |
| Answer» B. Solutions | |
| 117. |
Why emulsion dosage form for lipophilic drug proved better? |
| A. | Easy manufacturing |
| B. | The higher stability of the drug in emulsion form |
| C. | Presented a large surface area of oil to the GIT for the absorption of the drug |
| D. | Fast clearance from the plasma |
| Answer» C. Presented a large surface area of oil to the GIT for the absorption of the drug | |
| 118. |
Which is the major rate-limiting step in the absorption of a drug from suspension dosage? |
| A. | Tablet disintegration to granules |
| B. | Granules disintegration to fine particles |
| C. | Fine particles dissolution |
| D. | Dissolution absorbed into the blood |
| Answer» C. Fine particles dissolution | |
| 119. |
Which coating is thin and dissolves rapidly? |
| A. | Sugar coating |
| B. | Film coating |
| C. | Enteric coating |
| D. | Sealing coating |
| Answer» B. Film coating | |
| 120. |
Which option describes the function of the enteric coated drug? |
| A. | Tough dissolves slowly |
| B. | Thin dissolves completely |
| C. | Dissolves only in alkaline pH of the intestine |
| D. | Shellac coating |
| Answer» C. Dissolves only in alkaline pH of the intestine | |
| 121. |
Hydrophobic drug with fine particle size in capsule results in a decreasing porosity of powder bed. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 122. |
Viscous fluids and oils are administered in hard gelatin capsules. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 123. |
From the below options which will be the most widely used form of dosage? |
| A. | Emulsion |
| B. | Solutions |
| C. | Tablets |
| D. | Powders |
| Answer» A. Emulsion | |
| 124. |
In cell membrane the hydrocarbon chains for hydrophilic phase and the polar heads form hydrophobic phase. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 125. |
Proteins interact with which part of the cell membrane? |
| A. | Hydrophobic tail |
| B. | Polar head |
| C. | Non polar head |
| D. | Hydrophilic tail |
| Answer» A. Hydrophobic tail | |
| 126. |
Which part of the membrane is responsible for the relative impermeability of polar molecules in and out of the cell? |
| A. | Polar head |
| B. | Hydrophobic head |
| C. | Hydrophobic core |
| D. | Non polar head |
| Answer» C. Hydrophobic core | |
| 127. |
What helps in the passing of inorganic ions? |
| A. | Ion channels |
| B. | Voltage gated channels |
| C. | Aqueous filled pores |
| D. | Diffusion |
| Answer» C. Aqueous filled pores | |
| 128. |
The cell membrane is ___________ |
| A. | Impermeable |
| B. | Semipermeable |
| C. | Permeable |
| D. | Permeable to only gases |
| Answer» B. Semipermeable | |
| 129. |
What is the most important characteristic of a drug to be absorbed after oral administration? |
| A. | Dissolved in HCL |
| B. | Dissolved in alkaline solution |
| C. | Can pass through the cell membrane |
| D. | Form aggregate and settle down |
| Answer» C. Can pass through the cell membrane | |
| 130. |
Cell membrane can pass easily Oxygen and Carbon dioxide. |
| A. | False |
| B. | True |
| C. | none |
| D. | all |
| Answer» B. True | |
| 131. |
Which one of these is an example of Enteral Route? |
| A. | Skin |
| B. | IV |
| C. | Gastrointestinal |
| D. | Inhalation |
| Answer» C. Gastrointestinal | |
| 132. |
Gastrointestinal route is an example of which of the major drug delivery routes? |
| A. | The enteral route |
| B. | The parenteral route |
| C. | The topical route |
| D. | The intravenous route |
| Answer» A. The enteral route | |
| 133. |
Which form of drug formulation has disintegration time? |
| A. | Injections |
| B. | Syrups |
| C. | Capsules and Tablets |
| D. | Only tablets |
| Answer» C. Capsules and Tablets | |
| 134. |
Which tablets have longer Disintegration time? |
| A. | Single coated tablets |
| B. | Uncoated tablets |
| C. | Sugar-coated tablets |
| D. | Capsules |
| Answer» C. Sugar-coated tablets | |
| 135. |
Disintegration time is directly proportional to the amount of binder present in the tablet. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 136. |
Which of the following is not a form of excipients? |
| A. | Paracetamol |
| B. | Disintegrants |
| C. | Lubricants |
| D. | Binders |
| Answer» A. Paracetamol | |
| 137. |
Which of the following is not a limitation granulation? |
| A. | Formation of crystal bridge by the presence of liquid |
| B. | The liquid may act as a medium for affecting chemical reactions such as hydrolysis |
| C. | Increase the cost due to more additional processing |
| D. | The drying step may harm the thermolabile drugs |
| Answer» C. Increase the cost due to more additional processing | |
| 138. |
The agglomerative phase of the communication method grinds the drug in a ball mill for a long time to affect spontaneous agglomeration. But results showed tablets produced are softer. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 139. |
Which of these is not a characteristic of tablet formulation by Agglomerative phase of the communication process? |
| A. | Tablets are stronger |
| B. | Usage of more binding agent |
| C. | Rapid dissolution |
| D. | Increase in internal surface area of the granules |
| Answer» B. Usage of more binding agent | |
| 140. |
What does the graph of Rate of Drug dissolution v/s Compression force with this type of curve interpret? |
| A. | Tight binding of the molecules in drug |
| B. | Deformation of the drug particles into smaller particles |
| C. | The influence of compression force on the dissolution rate is difficult |
| D. | Both tight bonding and deformation of the drug molecules |
| Answer» A. Tight binding of the molecules in drug | |
| 141. |
What does the graph of Rate of Drug dissolution v/s Compression force with this type of curve interpret? |
| A. | Tight binding of the molecules in drug |
| B. | Deformation of the drug particles into smaller particles |
| C. | The influence of compression force on the dissolution rate is difficult |
| D. | Both tight bonding and deformation of the drug molecules |
| Answer» D. Both tight bonding and deformation of the drug molecules | |
| 142. |
Capsules with bigger particles and intense packing have poor drug release and dissolution rate due to an increase in the pore size. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» B. False | |
| 143. |
Which one of them is not a common form of excipients of drug manufacturing? |
| A. | Diluents |
| B. | Binders |
| C. | Sweeteners |
| D. | Essential oils |
| Answer» D. Essential oils | |
| 144. |
Vehicles are the solvent system for the liquefied drug. Which one of them is not an example of a kind of vehicle? |
| A. | Aqueous vehicle |
| B. | Non-aqueous water-miscible vehicles |
| C. | Non-aqueous water immiscible vehicles |
| D. | A salt solution of the drug |
| Answer» D. A salt solution of the drug | |
| 145. |
Which one of the following will be an example of organic diluents? |
| A. | Starch |
| B. | Dicalcium phosphate |
| C. | Tetracycline |
| D. | Tween 80 |
| Answer» A. Starch | |
| 146. |
What is the function of a granulating agent in drug formulation? |
| A. | Promote cohesive compacts |
| B. | Added if the required dosage is inadequate so that necessary bulk can be produced |
| C. | Tablets can disintegrate easily |
| D. | Used as solubilizer |
| Answer» A. Promote cohesive compacts | |
| 147. |
What is the full form of PVP and what is its function in drug formation? |
| A. | Polyvinyl propylene, diluent |
| B. | Polyvinyl pyrrolidine, solubilizing agent |
| C. | Polyvinyl propylene, buffering agent |
| D. | Polyvinyl pyrrolidine, Binding agent |
| Answer» B. Polyvinyl pyrrolidine, solubilizing agent | |
| 148. |
Which one of the following sentences depicts the function of Disintegrants correctly? |
| A. | These agents help in holding the powders together to form granules |
| B. | These agents overcome the cohesive strength of the tablets and help in dissolution |
| C. | These agents help in the flow of granules and reduce friction between particles |
| D. | Added when the required dosage is inadequate |
| Answer» B. These agents overcome the cohesive strength of the tablets and help in dissolution | |
| 149. |
A large amount of binders tends to increase the hardness of tablets. |
| A. | True |
| B. | False |
| C. | none |
| D. | all |
| Answer» A. True | |
| 150. |
An example of lubricants will be __________ |
| A. | PVP |
| B. | Carbowaxes |
| C. | CMC |
| D. | Tetracycline |
| Answer» B. Carbowaxes | |
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