McqMate
These multiple-choice questions (MCQs) are designed to enhance your knowledge and understanding in the following areas: Uncategorized topics .
| 51. |
Lubricant used in tablet formulation for |
| A. | to lubricate all ingredient in the tablet |
| B. | prevent adhesion of tablet material to surface area of dies |
| C. | reduce interparticle friction,improve rate of flow |
| D. | both a&b |
| Answer» D. both a&b | |
| 52. |
Which of the superdisintegrants are used in tablet formulation |
| A. | croscarmelose |
| B. | crospovidone |
| C. | both a&b |
| D. | none of above |
| Answer» C. both a&b | |
| 53. |
Thinner the tablet indicates that |
| A. | hard tablet |
| B. | size is less |
| C. | soft tablet |
| D. | none of above |
| Answer» A. hard tablet | |
| 54. |
Which of the following material used in enteric coated tablet |
| A. | cap |
| B. | hpmc |
| C. | mcc |
| D. | hpc |
| Answer» A. cap | |
| 55. |
Which is the following modified starch |
| A. | starx-1500 |
| B. | rx-500 |
| C. | both a&b |
| D. | none of above |
| Answer» A. starx-1500 | |
| 56. |
Which are the following apparatus used for tablet hardnes testing |
| A. | monsanto |
| B. | strong cob |
| C. | roache |
| D. | both a&b |
| Answer» A. monsanto | |
| 57. |
Unit of hardness |
| A. | kg/sq.in |
| B. | kg/sq.foot |
| C. | mg/sq.cm |
| D. | kg/sq.cm |
| Answer» D. kg/sq.cm | |
| 58. |
According to USP type I dissolution apparatus is |
| A. | basket |
| B. | paddle |
| C. | basket and paddle |
| D. | none of above |
| Answer» A. basket | |
| 59. |
Which are the following apparatus used for friability testing |
| A. | roache fribilator |
| B. | pfizer |
| C. | orasaka fribilator |
| D. | none of above |
| Answer» A. roache fribilator | |
| 60. |
According to USP standard limit for friability test is |
| A. | 0.5-1% |
| B. | 0.4-1% |
| C. | 0.8-1.2% |
| D. | 0.1-1% |
| Answer» A. 0.5-1% | |
| 61. |
According to IP disintegration time for dispersible tablet is |
| A. | within 3 min in water at 250c + 10c |
| B. | within 2 min in water at 250c+10c |
| C. | within 1 min in water at 270c |
| D. | none of above |
| Answer» A. within 3 min in water at 250c + 10c | |
| 62. |
According to std sparingly soluble means |
| A. | less than 1 part of solvent required for 1 part of solute |
| B. | from 10-30 parts of solvent required for 1 part of solute |
| C. | from 1000 to 10000 parts of solvent required for 1 part of solute |
| D. | from 100 to 1000 parts of solvent required for 1 part of solute |
| Answer» A. less than 1 part of solvent required for 1 part of solute | |
| 63. |
Seperation of tablet into two or more distinct layer |
| A. | capping |
| B. | lamination |
| C. | shipping |
| D. | both a&b |
| Answer» B. lamination | |
| 64. |
Unequal distribution of colour on a tablet with dark spot is |
| A. | mottling |
| B. | colour variation |
| C. | orange peel effect |
| D. | both a & b |
| Answer» D. both a & b | |
| 65. |
Chipping is the tablet defect in |
| A. | breaking of tablet edges |
| B. | crack of tablet surface |
| C. | adhering tablet to die wall |
| D. | stick of tablet |
| Answer» A. breaking of tablet edges | |
| 66. |
Which of the following is principal area of preformulation |
| A. | bulk characterization |
| B. | solubility analysis |
| C. | stability analysis |
| D. | all of above |
| Answer» A. bulk characterization | |
| 67. |
Which are the form are more stable |
| A. | crystalline |
| B. | amorphous |
| C. | polymorphs |
| D. | entiotrops |
| Answer» D. entiotrops | |
| 68. |
Which of the following form having less solubility and lesser tendency to change its form during storage |
| A. | amorphous form |
| B. | crystalline |
| C. | botha&b |
| D. | none of above |
| Answer» A. amorphous form | |
| 69. |
Metastable form having tendency to convert into |
| A. | stable form |
| B. | unstable form |
| C. | amorphous form |
| D. | none of above |
| Answer» B. unstable form | |
| 70. |
Deliquesent materials means |
| A. | they absorb sufficient amount of moisture b) they absorb moisture |
| B. | they absorb moisture |
| C. | they losses the water |
| D. | none of the above |
| Answer» A. they absorb sufficient amount of moisture b) they absorb moisture | |
| 71. |
Which of the following method used for amount of moisture absorb determination |
| A. | gravimetry |
| B. | tga |
| C. | karl-fischer titration |
| D. | all of the above |
| Answer» A. gravimetry | |
| 72. |
Which of the following ingredient or polymer used in enteric coated tablet and for purpose of are |
| A. | cap(cellulose acetate phthalate ) |
| B. | mcc for resistant to acidic ph |
| C. | for resistant to acidic ph |
| D. | none of the above |
| Answer» C. for resistant to acidic ph | |
| 73. |
Controlled drug delivery system recently been marketed as |
| A. | rate-preprogrammed drug delivery system |
| B. | activation-modulated drug delivery system |
| C. | site-targeting drug delivery system |
| D. | all of the above |
| Answer» D. all of the above | |
| 74. |
Various types of polymer membrane permeation-controlled drug delivery systems includes |
| A. | sphere |
| B. | cylinder |
| C. | sheet |
| D. | all of the above |
| Answer» D. all of the above | |
| 75. |
Following parameters play varying degrees of rate-limiting roles in controlling the release of drug molecules from membrane permeation or matrix diffusion |
| A. | partition coefficient |
| B. | diffusional path thickness |
| C. | solubility |
| D. | all of the above |
| Answer» D. all of the above | |
| 76. |
The diffusion of small molecules in a polymer structure is an |
| A. | energy-activated process |
| B. | increase in concentration |
| C. | increase in no of small molecules |
| D. | all of the above |
| Answer» A. energy-activated process | |
| 77. |
The controlled release of a drug species from both polymer membrane and polymer matrix controlled drug delivery systems is governed by |
| A. | ???? fick’s law of diffusion |
| B. | ???? arrhenius relationship |
| C. | ???? both a & b |
| D. | ?? none of the above |
| Answer» A. ???? fick’s law of diffusion | |
| 78. |
In establishing a good in vitro & in vivo correlation of CDDS following should consider |
| A. | pharmaceutics aspects of controlled release drug delivery systems |
| B. | bio-pharmaceutics and pharmacokinetics of the therapeutic agent in the body after its delivery from a drug delivery systems |
| C. | pharmacodynamics of the therapeutic agent at the site of drug actions |
| D. | all of the above |
| Answer» D. all of the above | |
| 79. |
Solubilization of poorly soluble drugs in aqueous solution can be effectively accomplished by using |
| A. | co-solvent systems |
| B. | increase in the concentration of drugs |
| C. | both a & b |
| D. | none of the above |
| Answer» A. co-solvent systems | |
| 80. |
The effect of partition coefficient on the controlled release of drugs from a matrix type drug delivery device was reported as |
| A. | the mechanism of drug release were dependent upon the variation in the partition coefficient |
| B. | the rate profile of drug release were dependent upon the variation in the partition coefficient |
| C. | both a & b |
| D. | none of the above |
| Answer» C. both a & b | |
| 81. |
Fillers are often incorporated into polymer to enhance |
| A. | kinetic strength |
| B. | mechanical strength |
| C. | none of the above |
| D. | both a & b |
| Answer» B. mechanical strength | |
| 82. |
Both the in-vitro and in-vivo rates of drug release are observed to be dependent on |
| A. | upon the surface area of drug delivery device |
| B. | different lengths of treatment |
| C. | both a & b |
| D. | none of the above |
| Answer» C. both a & b | |
| 83. |
One of the materials listed below is most commonly used in film coating of Tablets, Identify. |
| A. | (a) hydroxypropyl methyl cellulose |
| B. | (b) acacia |
| C. | (c) simple syrup |
| D. | (d) bees wax |
| Answer» A. (a) hydroxypropyl methyl cellulose | |
| 84. |
The loading dose of a drug is usually based on |
| A. | (a) total body clearance of the drug |
| B. | (b) percentage of drug bound to plasma proteins |
| C. | (c) fraction of drug excreted unchanged in urine |
| D. | (d) apparent volume of distribution and desired drug concentration in plasma |
| Answer» D. (d) apparent volume of distribution and desired drug concentration in plasma | |
| 85. |
The characteristics of a good NDDS carrier are: |
| A. | (a) optimum drug quantity can be loaded into it. |
| B. | (b) the release of the drug inside the body is pulsatile in nature. |
| C. | (c) it should not be immunogenic in nature. |
| D. | (d) all of the above |
| Answer» D. (d) all of the above | |
| 86. |
Tablet is one of the following forms that an oral drug can take such as |
| A. | (a)?????? syrups & suspension |
| B. | (b)???? elixirs & emulsion |
| C. | (c)?????? both a & b |
| D. | (d)???? none of the above |
| Answer» C. (c)?????? both a & b | |
| 87. |
A wide variety of binders used in tablet dosage form some common one including |
| A. | (a) dibasic calcium phosphate |
| B. | (b) corn (maize) starch |
| C. | (c ) povidone polyvinylpyrrolidone and modified cellulose |
| D. | (d)?????????? all of the above |
| Answer» D. (d)?????????? all of the above | |
| 88. |
The hardness of tablets is the principle measurement of |
| A. | (a) mechanical strength |
| B. | (b) kinetic energy |
| C. | (c ) both a & b |
| D. | (a)?????? none of the above |
| Answer» A. (a) mechanical strength | |
| 89. |
Capsules are made from aqueous solutions of gelling agents like |
| A. | (a) animal protein mainly gelatin |
| B. | (b) plant polysaccharides |
| C. | (c ) modified forms of starch and cellulose |
| D. | (d) all the above |
| Answer» D. (d) all the above | |
| 90. |
Vegetable capsules are composed of |
| A. | (a) hypromellose |
| B. | (b) a polymer formulated from cellulose |
| C. | (c) both a & b |
| D. | (d) none of the above |
| Answer» C. (c) both a & b | |
| 91. |
The applicability of Noyes-Whitney equation is to describe |
| A. | (a) first order kinetics???????????? |
| B. | (b) zero order kinetics |
| C. | (c) mixed order kinetics?????? |
| D. | (d) dissolution rate |
| Answer» D. (d) dissolution rate | |
| 92. |
The ability of human eye using illuminated area to detect a particle is limited to |
| A. | (a) 0.4 micron???????? |
| B. | (b) 25 micron???????? |
| C. | (c) 50 micron???????? |
| D. | (d) 10 micron |
| Answer» D. (d) 10 micron | |
| 93. |
Which filler can NOT be used for the preparation of tablets for amine containing basic drugs to avoid discoloration of the tablets? |
| A. | (a) dicalcium phosphate?????????? |
| B. | (b) microcrystalline cellulose |
| C. | (c) starch?????????????????? ???????????????????????? ???? ?? |
| D. | (d) lactose |
| Answer» D. (d) lactose | |
| 94. |
In which of the following techniques the sample is kept below triple point? |
| A. | (a) lyophilization???????????????????? ?? |
| B. | (b) spray drying |
| C. | (c) spray congealing?????????????? ?? |
| D. | (d) centrifugation |
| Answer» A. (a) lyophilization???????????????????? ?? | |
| 95. |
Drugs in suspensions and semi-solid formulations always degrade by |
| A. | (a) first order kinetics???????????????? |
| B. | (b) second order kinetics |
| C. | (c) zero order kinetics???????????????? |
| D. | (d) non-linear kinetics |
| Answer» C. (c) zero order kinetics???????????????? | |
| 96. |
Modified release drug delivery systems may be divided conveniently in to following categories |
| A. | (a) delayed release & sustained release |
| B. | (b) site specific targeting & receptor targeting |
| C. | (c) both a & b |
| D. | (d) none of the above |
| Answer» C. (c) both a & b | |
| 97. |
According to USP, the speed regulating device of the dissolution apparatus should be capable of maintaining the speed within limits of what % of the selected speed? |
| A. | (a)???? 1%?????? |
| B. | (b)???? 2%?????? |
| C. | (c)???? 4%?????? |
| D. | (d)???? 5% |
| Answer» A. (a)???? 1%?????? | |
Done Studing? Take A Test.
Great job completing your study session! Now it's time to put your knowledge to the test. Challenge yourself, see how much you've learned, and identify areas for improvement. Don’t worry, this is all part of the journey to mastery. Ready for the next step? Take a quiz to solidify what you've just studied.