Chapter: Molecular Basis of Inheritance
51.

How many nucleotides make one okazaki segment in eukaryotes ?

A. 1000-1500
B. 100-200
C. 5000
D. Not fixed
Answer» A. 1000-1500
52.

Which of the following enzymes help in the process of formation of phosphodiester bond during reverse transcription ?

A. DNA - dependant RNA polymerase
B. DNA dependant DNA polymerase
C. RNA - dependant RNA polymerase
D. RNA - dependant DNA polymerase
Answer» D. RNA - dependant DNA polymerase
53.

The two strands of a DNA molecule are separted and one of them is analysed for its A + T / G + C ratio, This is found to be 0.2 What is the A + T / G + C ratio of the other strand

A. 0.02
B. 0.08
C. 0.8
D. 0.2
Answer» D. 0.2
54.

DNA replication in lagging strand of most of the eukaryotic organis ms is

A. conservative and continuous
B. semi conservative but discontinuous
C. conservative and semi - discontinuous
D. semi conservative but continuous
Answer» B. semi conservative but discontinuous
55.

How many bases consist in an average gene ?

A. 3, 00, 000
B. 3000
C. 4, 00, 000
D. 4000
Answer» B. 3000
56.

Match the following using salient features of Human genome project A B
(P) Less than 2 % genome (i) 3 billion nucleotide bases
(Q) Chromosome 1 (ii) 231 genes
(R) Y chromosome (iii) 2968 genes
(S) Human genome (iv) codes for protein

A. (P - iv) (Q - iii) ( R - ii) ( S - i)
B. ( P - iv) (Q - ii) (R - iii) (S - i)
C. (P - iv) (Q - i) (R - ii) (S - iii)
D. (P - i) (Q - iii) (R - iv) (S - ii)
Answer» A. (P - iv) (Q - iii) ( R - ii) ( S - i)
57.

State the use of moleculer medicine ?

A. Improves diagnosis of diseases
B. Used as gene theraphy
C. Used to understand several diseass like Alzheimer’s Parkinsons diseases etc.,
D. All the above
Answer» D. All the above
58.

Among the following which is used for separation of DNA fragments ?

A. centifugation
B. Cell fractionation
C. Cell homogenation
D. Electrophoresis
Answer» D. Electrophoresis
59.

In Which of the following DNA not directly involved ?

A. Repication
B. Transcription
C. Translation
D. Transformation
Answer» C. Translation
60.

Transcription begins when one of the following enzymes binds to promotor site.

A. DNA polymerase
B. RNA polymerase
C. helicase
D. Gyrase
Answer» B. RNA polymerase
61.

What dose A & B represent ?

A. Grycase , Helicase
B. Double Stranded Protein, Helicase
C. Helicase, Single strand binding protein
D. Topoisomerase Helicase
Answer» C. Helicase, Single strand binding protein
62.

State the process and mention the labelled protion.

A. Process of Translation - X-RNA Polymerase- Y-DNA Template- Z-m RNA Transcript
B. process of Transcription - X-RNA Polymerase- Y-DNA Template- Z- RNA Transcript
C. process of Translocation - X-DNA polymerase- Y- Template- Z- Transcript
D. Process of Transformation - X - DNA polymerase- Y - RNA template- Z - RNA transcript
Answer» B. process of Transcription - X-RNA Polymerase- Y-DNA Template- Z- RNA Transcript
63.

What do P, Q, R and S regions of t RNA ?

A. P - Anticodon loop
B. P. D LoopQ - Variable loop Q - T ψ c loopR - T ψ c loop R - Variable loopS - D Loop S - Anticodon loop
C. P - T ψ c loop
D. P - Anticodon LoopQ - D loop Q - T ψ c loop R - Anticodon loop R - D loop S - Variable loop S - Variable loop
Answer» A. P - Anticodon loop
64.

Which state is represent by the above model

A. Repressed state of lac operon
B. Inactive state of Lac operon
C. Active state of Lac operon
D. Induced state of Lac operon
Answer» A. Repressed state of lac operon
65.

What does X replesent in the above diagram

A. Released polypeptide chain
B. Released 3D protein molecule
C. Released secondary protein
D. Released tertiary protein
Answer» A. Released polypeptide chain
66.

What does ‘X’ represent

A. gene
B. segment of DNA
C. seqment of DNA coding for specific protein
D. Both A & C
Answer» D. Both A & C
67.

Write the codon for the anticodon on the t - RNA

A. AGU
B. UGU
C. UGA
D. ACU
Answer» A. AGU
68.

In the genetic code dictionary how many codons are used to code for all the 20 essential amino-acids? (AIPMT - 2003)

A. 20
B. 64
C. 61
D. 60
Answer» B. 64
69.

What would happen if in a gene encoding polypeptide of 50 aminoacids 25th codon (UAU) is mutated to UAA ? (AIPMT - 2003)

A. A Polypeptide of 24 aminoacids will be formed
B. Two polypeptides of 24 and 25 aminoacids will be formed
C. A polypeptide of 49 aminoacids will be formed
D. A polypeptide of 25 aminoacids will be formed
Answer» A. A Polypeptide of 24 aminoacids will be formed
70.

Which one of the following triplet codes, is correctly matched with its specificity for an aminoacid in protein synthesis or as ‘start’ or ‘stop’ codon ?

A. UCG - start
B. UUU - stop
C. UGU - Leucine
D. UAC - Tyrosine
Answer» D. UAC - Tyrosine
71.

What does “Lac” refer to in what we call the lac operon ? (AIPMT - 2003)

A. Lactose
B. Lactase
C. Lac insect
D. The number 1,00,000
Answer» A. Lactose
72.

The following ratio is generally constant for a given species (AIPMT - 2004)

A. A + G / C + T
B. T + C / G + A
C. G + C / A + T
D. A + C / T + G
Answer» C. G + C / A + T
73.

During transcription if the nucleotide sequence of the DNA strand that is being coded is ATACG then the nucleotide sequence in the m RNA would be (AIPMT - 2004)

A. TATGC
B. T C T G G
C. U A U G C
D. U A T G C
Answer» C. U A U G C
74.

Which one of the following makes use of RNA template to synthesize DNA (AIPMT - 2005)

A. DNA polymerase
B. RNA polymerase
C. Reverse transcriptase
D. DNA dependant RNA polymerase
Answer» C. Reverse transcriptase
75.

Protein synthesis is an animal cell occurs (AIPMT - 2005)

A. only on the ribosomes present in cytosol
B. only on ribosomes attached to the nuclear envelope and endoplasmic reticulum
C. On ribosomes present in the nucleolus as well as in cytoplasm
D. on ribosomes present in cytoplasm as well as in mitochondria
Answer» D. on ribosomes present in cytoplasm as well as in mitochondria
76.

E coli cells with a mutant z gene of the lac operon cannot grow in medium containing only lactose as the source of energy because (AIPMT - 2005)

A. the lac operon is constitutively active in these cells
B. they cannot synthesize functional beta galactosidase
C. in the presence of glucose E Coli cell do not utilize lactose
D. they cannot transport lactose from the medium into the cell
Answer» B. they cannot synthesize functional beta galactosidase
77.

Aminoacid Sequence in protein synthesis is decided by the sequence of (AIPMT - 2006)

A. r RNA
B. t- RNA
C. m RNA
D. c DNA
Answer» C. m RNA
78.

Antiparallel strands of a DNA molecule means that (AIPMT - 2006)

A. One strand turns clockwise
B. One strand turns anticlockwise
C. The phosphate groups of two DNA strands , at their ends share the same position
D. The phosphate groups at the start of two DNA strands are is opposite position (Pole).
Answer» D. The phosphate groups at the start of two DNA strands are is opposite position (Pole).
79.

Polysome is formed by (AIPMT - 2008)

A. a ribosome with several subunits
B. ribosomes attached to each other in a linear arrangement
C. several ribosomes attached to a single m RNA
D. many ribosomes attached to a strand of endoplasmic reticulum
Answer» C. several ribosomes attached to a single m RNA
80.

Whose experiments cracked the DNA and discovered unequivocally that a genetic code is a “triplet” (AIPMT - 2009)

A. Hershey and chase
B. Morgan and sturtevant
C. Beadle and Tatum
D. Nirenberg and Mathai
Answer» D. Nirenberg and Mathai
81.

Select the two correct statement out of the four statement given below about “ Lac opern”(AIPMT-2010)
(i) Glucose or galactose may bind with the repressor and inactivate it
(ii) In the absence of lactose the repressor bind with the operator region
(iii) The Z -gene codes for permease
(iv) This was elucidated by Francois Jacob and Jacques Monod
The correct statements are

A. ii and iii
B. i and iii
C. ii and iv
D. i and ii
Answer» C. ii and iv
82.

Which one of the following does not follow the central dogma of molecular biology ? (AIPMT - 2010)

A. Pea
B. Mucor
C. Chlamydomonas
D. HIV
Answer» D. HIV
83.

The lac opern consists of (AIPMT - 2010)

A. four regulatory genes only
B. One regulatory gene and three structural genes
C. Two regulatory genes and three structural genes
D. three regulatory genes and three structural genes
Answer» C. Two regulatory genes and three structural genes
84.

The 31 - 51Phosphodiester linkages inside a potynucleotide chain serve to join AIPMT - 2010)

A. One DNA strand with the other DNA strand
B. One nucleoside with another nucleoside
C. One nucleotide with another nucleotide
D. One nitrogen base with pentose sugar
Answer» C. One nucleotide with another nucleotide
85.

Ribosomal RNA is actively synthesized by

A. Lysosomes
B. nucleolus
C. nucleoplasm
D. ribosomes
Answer» B. nucleolus
86.

If one strand of DNA has the nitrogenous base sequence as ATCTG, What would be the complementary RNA strand Sequence (AIPMT - 2012)

A. TTAGU
B. UAGAC
C. AACTG
D. ATCGU
Answer» B. UAGAC
87.

Semiconservative DNA replication using 15 N was demonstrated by (AIIMS -1994)

A. Meselson
B. Taylor
C. Meselson and stahl
D. Hershey and chase
Answer» C. Meselson and stahl
88.

In operan concept, the operator gene combines with (AIIMS -1986)

A. Regulator protein to switch off structural gene transcription
B. Regulator protein to switch on structural gene transcription
C. Inducer to switch off structural gene transcription
D. Regulator gene to switch off structural gene transcription
Answer» A. Regulator protein to switch off structural gene transcription
89.

Termination of polypeptide chain is brought about by

A. UUG , UAG and UCG
B. UAA , UAG and UGA
C. UUG , UGC and UCA
D. UCG , GCG and ACC
Answer» B. UAA , UAG and UGA
90.

RNA that picks up specific aminoacid from amino acid pool of cytoplasm to carry it to ribosome during protein synthesis is

A. t RNA
B. m RNA
C. r RNA
D. g RNA
Answer» A. t RNA
91.

Correct sequenceof code transfer during polypeptide formation is (AIIMS -1999)

A. DNA , mRNA , t RNA and amino acids
B. DNA , t RNA , r RNA and m RNA
C. m RNA , t RNA , DNA and amino acids
D. r RNA , DNA ,m RNA and t RNA
Answer» A. DNA , mRNA , t RNA and amino acids
92.

Best method to determine paternity is

A. Protein analysis
B. chromosome counting
C. gene counting
D. DNA finger printing
Answer» D. DNA finger printing
93.

DNA is copied from m-RNA molecule with help of

A. Restriction enzyme
B. Reverse transcriptase
C. DNA polymerase
D. Adenosine deaminase
Answer» B. Reverse transcriptase
94.

Nucleotide arrangement in DNA can be seen by

A. X - ray crystallography
B. Electron microscope
C. Ultra centrifuge
D. Light microscope
Answer» A. X - ray crystallography
95.

Pneumococcus experiment proved that (AFMC - 1993)

A. Bacteria do not reproduce asexuallly
B. Bacteria undergo binary fission
C. DNA is genetic material
D. RNA may sometimes control a production of DNA and protein
Answer» C. DNA is genetic material
96.

A DNA nucletotide chain has A G C T T C G A sequence The nucleotide sequence of other chain would be

A. T C G A A G C T
B. G C T A A G C T (AFMC - 1993)
C. T A G C A T A T
D. G A T C C T A G
Answer» A. T C G A A G C T
97.

A functional unit in synthesis of protein is (MPPMT - 1994)

A. Lysosome
B. Peroxisome
C. Polysome
D. Dictyosome
Answer» C. Polysome
98.

VNTR is employed for (AMU - 2002)

A. Protoplasmic culture
B. DNA finger printing
C. Regulation of plant growth hormones
D. Enhancing photosynthesis in desert plant
Answer» B. DNA finger printing
99.

Out of 64 codons 61 code for 20 types of aminoacids It is due to (CBSE - 2002)

A. Overlapping genes
B. Degeneracy of genetic code
C. Wobbling of codons
D. Universality of codons
Answer» B. Degeneracy of genetic code
100.

Okazaki fragments are joined by enzyme (Kerala 2005)

A. DNA helix
B. DNA ligase
C. DNA polymerase II
D. RNA polymerase II
Answer» B. DNA ligase

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